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Open Access 01-07-2009 | Brief Report

Soluble Triggering Receptor Expressed on Myeloid cells-1 in bronchoalveolar lavage fluid is not predictive for ventilator-associated pneumonia

Authors: Guy J. Oudhuis, Judith Beuving, Dennis Bergmans, Ellen E. Stobberingh, Guul ten Velde, Catharina F. Linssen, Annelies Verbon

Published in: Intensive Care Medicine | Issue 7/2009

Abstract

Purpose

Soluble Triggering Receptor Expressed on Myeloid cells-1 (sTREM-1) has proven to be a good biomarker for sepsis. For the diagnosis ventilator-associated pneumonia (VAP), however, there have only been a few, relatively small, studies on the role of this receptor. The aim of the study was to evaluate the usefulness of sTREM-1 in bronchoalveolar lavage fluid (BALF) from Intensive Care Unit patients as rapid diagnostic test for VAP.

Methods

The concentration of sTREM-1 in 240 BALF samples was measured using a quantitative sandwich enzyme immunoassay. Two researchers who were blind to the assay results determined whether a VAP was present or not. Clinical suspicion of a VAP was confirmed by the presence of ≥2% cells containing intracellular organisms and/or a quantitative culture result of ≥10⁴ colony forming units per millilitre BALF.

Results

The mean concentration of sTREM-1 was significantly higher in the BALF of patients with confirmed VAP than in that of patients without confirmed VAP. However, the area under the receiver-operating characteristic curve was 0.58 (95% confidence interval 0.50–0.65, P = 0.04).

Conclusions

The results imply that the sTREM-1 assay in BALF may not be discriminative for VAP.

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Title: Soluble Triggering Receptor Expressed on Myeloid cells-1 in bronchoalveolar lavage fluid is not predictive for ventilator-associated pneumonia
Authors: Guy J. Oudhuis
Judith Beuving
Dennis Bergmans
Ellen E. Stobberingh
Guul ten Velde
Catharina F. Linssen
Annelies Verbon
Publication date: 01-07-2009
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 7/2009
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-009-1463-y

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Soluble Triggering Receptor Expressed on Myeloid cells-1 in bronchoalveolar lavage fluid is not predictive for ventilator-associated pneumonia

Abstract

Purpose

Methods

Results

Conclusions

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Abstract

Purpose

Methods

Results

Conclusions

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