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Intensive Care Medicine

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01-05-2007 | Brief Report

The effect of exogenous surfactant in patients with lung contusions and acute lung injury

Authors: I. Tsangaris, E. Galiatsou, E. Kostanti, G. Nakos

Published in: Intensive Care Medicine | Issue 5/2007

Abstract

Objective

To investigate the acute effect of surfactant replacement in multiple-trauma patients with lung contusion and acute lung injury.

Design and setting

Prospective randomized clinical trial in the 14-bed ICU of a 750-bed university hospital.

Patients and participants

Sixteen ventilated trauma patients with severe refractory hypoxemia (PaO₂/FIO₂ < 150 mmHg) and lung contusions.

Interventions

Patients were randomly assigned to either surfactant administration (n = 8) or standard treatment (n = 8). A single dose of natural bovine surfactant was instilled bronchoscopically in the involved lung areas; each segmental bronchus received (200/19) mg/kg body weight.

Measurements and results

The surfactant group demonstrated an acute improvement in oxygenation after surfactant replacement compared both to control group and to baseline values. In the surfactant group PaO₂/FIO₂ increased from 100 ± 20 mmHg at baseline to 140 ± 20 (6 h), 163 ± 26 (12 h), and 187 ± 30 mmHg (24 h). Compliance increased from 30 to 36 ml/cmH₂O at 6 h after administration, and this increase remained significant at the 24, 48, and 72 h time points. The surfactant group demonstrated a higher response to recruitment maneuvers than the control group at 6 h. The mean duration of ventilatory support was 5.6 ± 2.6 days in the surfactant group and 8.1 ± 2.4 days in the control group.

Conclusions

Surfactant replacement was well tolerated in patients with lung contusions and severe hypoxemia and resulted in improved oxygenation and compliance.

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Title: The effect of exogenous surfactant in patients with lung contusions and acute lung injury
Authors: I. Tsangaris
E. Galiatsou
E. Kostanti
G. Nakos
Publication date: 01-05-2007
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 5/2007
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-007-0597-z

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The effect of exogenous surfactant in patients with lung contusions and acute lung injury

Abstract

Objective

Design and setting

Patients and participants

Interventions

Measurements and results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objective

Design and setting

Patients and participants

Interventions

Measurements and results

Conclusions

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