Published in:
01-09-2019 | Hyperglycemia | Letter
Blood Mg2+ is more closely associated with hyperglycaemia than with hypertriacylglycerolaemia: the PREVEND study
Authors:
Peter R. van Dijk, Joëlle C. Schutten, Elias J. Jeyarajah, Jenny E. Kootstra-Ros, Margery A. Connelly, Stephan J. L. Bakker, Robin P. F. Dullaart
Published in:
Diabetologia
|
Issue 9/2019
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Excerpt
To the Editor: Mg
2+ affects beta cell function and insulin signalling and the relevance of abnormalities in Mg
2+ regulation for the development of type 2 diabetes mellitus is being increasingly appreciated [
1‐
3]. Kurstjens et al recently reported that an increase in serum non-esterified fatty acids and triacylglycerols in response to an oral fat challenge is paralleled by reduced Mg
2+ concentrations, thereby linking triacylglycerol metabolism to Mg
2+ homeostasis [
4]. In 285 individuals with a BMI >27 kg/m
2, they also observed that circulating Mg
2+ levels, measured with a routinely available colourimetric assay (Roche/Hitachi, Tokyo, Japan), were inversely correlated with triacylglycerols and with large very-low-density lipoproteins, but not significantly so with plasma glucose [
4]. In a cohort of 395 participants with type 2 diabetes, the same group showed inverse correlations of plasma Mg
2+ with both triacylglycerols and glucose [
5]. …