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Open Access 01-03-2019 | Research Letter

One hour post-load plasma glucose and 3 year risk of worsening fasting and 2 hour glucose tolerance in the RISC cohort

Authors: Melania Manco, Andrea Mari, John Petrie, Geltrude Mingrone, Beverley Balkau, for the EGIR-RISC study group

Published in: Diabetologia | Issue 3/2019

Excerpt

To the Editor: The 1 h post-load plasma glucose (1hPG) measurement has the potential to serve as a sensitive screening tool for identifying people who, despite having normal glucose tolerance (NGT), are at high-risk of developing type 2 diabetes over the next few years [1, 2]. Screening would be timely, as beta cells are still functional and lifestyle and drug interventions may be effective in delaying diabetes onset. …

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Alyass A, Almgren P, Akerlund M et al (2015) Modelling of OGTT curve identifies 1 h plasma glucose level as a strong predictor of incident type 2 diabetes: results from two prospective cohorts. Diabetologia 58(1):87–97. https://doi.org/10.1007/s00125-014-3390-x CrossRefPubMed

Manco M, Panunzi S, Macfarlane DP et al (2010) One-hour plasma glucose identifies insulin resistance and beta-cell dysfunction in individuals with normal glucose tolerance: cross-sectional data from the Relationship between Insulin Sensitivity and Cardiovascular Risk (RISC) study. Diabetes Care 33(9):2090–2107. https://doi.org/10.2337/dc09-2261 CrossRefPubMedPubMedCentral

Paddock E, Hohenadel MG, Piaggi P et al (2017) One-hour and two-hour postload plasma glucose concentrations are comparable predictors of type 2 diabetes mellitus in Southwestern Native Americans. Diabetologia 60(9):1704–1711. https://doi.org/10.1007/s00125-017-4332-1 CrossRefPubMed

Pareek M, Bhatt DL, Nielsen ML et al (2018) Enhanced predictive capability of a 1-hour oral glucose tolerance test: a prospective population-based cohort study. Diabetes Care 41(1):171–177. https://doi.org/10.2337/dc17-1351 CrossRefPubMed

Bergman M, Manco M, Sesti G et al (2018) Petition to replace current OGTT criteria for diagnosing prediabetes with the 1-hour post-load glucose ≥ 155 mg/dl (8.6 mmol/l). Diab Res Clin Pract 146:18–33. https://doi.org/10.1016/j.diabres.2018.09.017 CrossRef

Mari A, Pacini G, Murphy E, Ludvik B, Nolan JJ (2001) A model-based method for assessing insulin sensitivity from the oral glucose tolerance test. Diabetes Care 24(3):539–548. https://doi.org/10.2337/diacare.24.3.539 CrossRefPubMed

Title: One hour post-load plasma glucose and 3 year risk of worsening fasting and 2 hour glucose tolerance in the RISC cohort
Authors: Melania Manco
Andrea Mari
John Petrie
Geltrude Mingrone
Beverley Balkau
for the EGIR-RISC study group
Publication date: 01-03-2019
Publisher: Springer Berlin Heidelberg
Published in: Diabetologia / Issue 3/2019
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-018-4798-5

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