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Diabetologia
Published in: Diabetologia 2/2015

01-02-2015 | Review

GLUT2, glucose sensing and glucose homeostasis

Author: Bernard Thorens

Published in: Diabetologia | Issue 2/2015

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Abstract

The glucose transporter isoform GLUT2 is expressed in liver, intestine, kidney and pancreatic islet beta cells, as well as in the central nervous system, in neurons, astrocytes and tanycytes. Physiological studies of genetically modified mice have revealed a role for GLUT2 in several regulatory mechanisms. In pancreatic beta cells, GLUT2 is required for glucose-stimulated insulin secretion. In hepatocytes, suppression of GLUT2 expression revealed the existence of an unsuspected glucose output pathway that may depend on a membrane traffic-dependent mechanism. GLUT2 expression is nevertheless required for the physiological control of glucose-sensitive genes, and its inactivation in the liver leads to impaired glucose-stimulated insulin secretion, revealing a liver-beta cell axis, which is likely to be dependent on bile acids controlling beta cell secretion capacity. In the nervous system, GLUT2-dependent glucose sensing controls feeding, thermoregulation and pancreatic islet cell mass and function, as well as sympathetic and parasympathetic activities. Electrophysiological and optogenetic techniques established that Glut2 (also known as Slc2a2)-expressing neurons of the nucleus tractus solitarius can be activated by hypoglycaemia to stimulate glucagon secretion. In humans, inactivating mutations in GLUT2 cause Fanconi–Bickel syndrome, which is characterised by hepatomegaly and kidney disease; defects in insulin secretion are rare in adult patients, but GLUT2 mutations cause transient neonatal diabetes. Genome-wide association studies have reported that GLUT2 variants increase the risks of fasting hyperglycaemia, transition to type 2 diabetes, hypercholesterolaemia and cardiovascular diseases. Individuals with a missense mutation in GLUT2 show preference for sugar-containing foods. We will discuss how studies in mice help interpret the role of GLUT2 in human physiology.
Literature
1.
Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS (2006) The receptors and cells for mammalian taste. Nature 444:288–294PubMedCrossRef
2.
de Araujo IE, Oliveira-Maia AJ, Sotnikova TD et al (2008) Food reward in the absence of taste receptor signaling. Neuron 57:930–941PubMedCrossRef
3.
Berthoud HR, Bereiter DA, Trimble ER, Siegel EG, Jeanrenaud B (1981) Cephalic phase, reflex insulin secretion. Neuroanatomical and physiological characterization. Diabetologia 20(Suppl):393–401PubMedCrossRef
4.
Dentin R, Denechaud PD, Benhamed F, Girard J, Postic C (2006) Hepatic gene regulation by glucose and polyunsaturated fatty acids: a role for ChREBP. J Nutr 136:1145–1149PubMed
5.
6.
Iizuka K, Bruick RK, Liang G, Horton JD, Uyeda K (2004) Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci U S A 101:7281–7286PubMedCentralPubMedCrossRef
7.
Wang H, Wollheim CB (2002) ChREBP rather than USF2 regulates glucose stimulation of endogenous L-pyruvate kinase expression in insulin-secreting cells. J Biol Chem 277:32746–32752PubMedCrossRef
8.
Prentki M, Matschinsky FM, Madiraju SR (2013) Metabolic signaling in fuel-induced insulin secretion. Cell Metab 18:162–185PubMedCrossRef
9.
Zhang Q, Ramracheya R, Lahmann C et al (2013) Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes. Cell Metab 18:871–882PubMedCentralPubMedCrossRef
10.
Marty N, Dallaporta M, Thorens B (2007) Brain glucose sensing, counterregulation, and energy homeostasis. Physiology (Bethesda) 22:241–251CrossRef
11.
Routh VH (2002) Glucose-sensing neurons: are they physiologically relevant? Physiol Behav 76:403–413PubMedCrossRef
12.
13.
14.
O’Malley D, Reimann F, Simpson AK, Gribble FM (2006) Sodium-coupled glucose cotransporters contribute to hypothalamic glucose sensing. Diabetes 55:3381–3386PubMedCentralPubMedCrossRef
15.
16.
17.
Mueckler M, Thorens B (2013) The SLC2 (GLUT) family of membrane transporters. Mol Asp Med 34:121–138CrossRef
18.
Uldry M, Ibberson M, Hosokawa M, Thorens B (2002) GLUT2 is a high affinity glucosamine transporter. FEBS Lett 524:199–203PubMedCrossRef
19.
Thorens B, Sarkar HK, Kaback HR, Lodish HF (1988) Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells. Cell 55:281–290PubMedCrossRef
20.
Johnson JH, Newgard CB, Milburn JL, Lodish HF, Thorens B (1990) The high K m glucose transporter of islets of Langerhans is functionally similar to the low affinity transporter of liver and has identical primary sequence. J Biol Chem 265:6548–6551PubMed
21.
Matschinsky FM (1996) A lesson in metabolic regulation inspired by the glucokinase sensor paradigm. Diabetes 45:223–241PubMedCrossRef
22.
Thorens B, Weir GC, Leahy JL, Lodish HF, Bonner-Weir S (1990) Reduced expression of the liver/beta-cell glucose transporter isoform in glucose-insensitive pancreatic beta cells of diabetic rats. Proc Natl Acad Sci U S A 87:6492–6496PubMedCentralPubMedCrossRef
23.
24.
Gremlich S, Bonny C, Waeber G, Thorens B (1997) Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels. J Biol Chem 272:30261–30269PubMedCrossRef
25.
Parrizas M, Maestro MA, Boj SF et al (2001) Hepatic nuclear factor 1-alpha directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets. Mol Cell Biol 21:3234–3243PubMedCentralPubMedCrossRef
26.
Gremlich S, Roduit R, Thorens B (1997) Dexamethasone induces posttranslational degradation of GLUT2 and inhibition of insulin secretion in isolated pancreatic beta cells. Comparison with the effects of fatty acids. J Biol Chem 272:3216–3222PubMedCrossRef
27.
Ohtsubo K, Takamatsu S, Gao C, Korekane H, Kurosawa TM, Taniguchi N (2013) N-Glycosylation modulates the membrane sub-domain distribution and activity of glucose transporter 2 in pancreatic beta cells. Biochem Biophys Res Commun 434:346–351PubMedCrossRef
28.
Ohtsubo K, Chen MZ, Olefsky JM, Marth JD (2011) Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport. Nat Med 17:1067–1075PubMedCentralPubMedCrossRef
29.
Ohtsubo K, Takamatsu S, Minowa MT, Yoshida A, Takeuchi M, Marth JD (2005) Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes. Cell 123:1307–1321PubMedCrossRef
30.
Thorens B, Wu Y-J, Leahy JL, Weir GC (1992) The loss of GLUT2 expression by glucose-unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment. J Clin Investig 90:77–85PubMedCentralPubMedCrossRef
31.
Ogawa Y, Noma Y, Davalli AM et al (1995) Loss of glucose-induced insulin secretion and GLUT2 expression in transplanted beta-cells. Diabetes 44:75–79PubMedCrossRef
32.
Guillam M-T, Hümmler E, Schaerer E et al (1997) Early diabetes and abnormal postnatal pancreatic islet development in mice lacking GLUT2. Nat Genet 17:327–330PubMedCrossRef
33.
Thorens B, Guillam MT, Beermann F, Burcelin R, Jaquet M (2000) Transgenic reexpression of GLUT1 or GLUT2 in pancreatic beta cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion. J Biol Chem 275:23751–23758PubMedCrossRef
34.
Guillemain G, Loizeau M, Pincon-Raymond M, Girard J, Leturque A (2000) The large intracytoplasmic loop of the glucose transporter GLUT2 is involved in glucose signaling in hepatic cells. J Cell Sci 113:841–847PubMed
35.
36.
Stolarczyk E, Guissard C, Michau A et al (2010) Detection of extracellular glucose by GLUT2 contributes to hypothalamic control of food intake. Am J Physiol Endocrinol Metab 298:E1078–E1087PubMedCrossRef
37.
Burcelin R, Thorens B (2001) Evidence that extrapancreatic GLUT2-dependent glucose sensors control glucagon secretion. Diabetes 50:1282–1289PubMedCrossRef
38.
Berthoud H-R, Neuhuber WL (2000) Functional and chemical anatomy of the afferent vagal system. Auton Neurosci Basic Clin 85:1–17CrossRef
39.
Berthoud H-R, Kressel M, Neuhuber WL (1992) An anterograde tracing study of the vagal innervation of rat liver, portal vein and biliary system. Anat Embryol 186:431–442PubMedCrossRef
40.
Niijima A (1984) The effect of d-glucose on the firing rate of glucose-sensitive vagal afferents in the liver in comparison with the effect of 2-deoxy-d-glucose. J Auton Nerv Syst 10:279–285PubMedCrossRef
41.
42.
Donovan CM, Hamilton-Wessler M, Halter JB, Bergman RN (1994) Primacy of liver glucosensors in the sympathetic response to progressive hypoglycemia. Proc Natl Acad Sci U S A 91:2863–2867PubMedCentralPubMedCrossRef
43.
Hamilton-Wessler M, Bergman RN, Halter JB, Watanabe RM, Donovan CM (1994) The role of liver glucosensors in the integrated sympathetic response induced by deep hypoglycemia in dogs. Diabetes 43:1052–1060PubMedCrossRef
44.
Russek M (1963) Participation of hepatic glucoreceptors in the control of intake of food. Nature 197:79–80PubMedCrossRef
45.
Burcelin R, Dolci W, Thorens B (2000) Portal glucose infusion in the mouse induces hypoglycemia. Evidence that the hepatoportal glucose sensor stimulates glucose utilization. Diabetes 49:1635–1642PubMedCrossRef
46.
Burcelin R, Dolci W, Thorens B (2000) Glucose sensing by the hepatoportal sensor is GLUT2-dependent. In vivo analysis in GLUT2-null mice. Diabetes 49:1643–1648PubMedCrossRef
47.
Burcelin R, Crivelli V, Perrin C et al (2003) GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization. J Clin Invest 111:1555–1562PubMedCentralPubMedCrossRef
48.
Preitner F, Ibberson M, Franklin I et al (2004) Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors. J Clin Invest 113:635–645PubMedCentralPubMedCrossRef
49.
Fukumoto H, Seino S, Imura H et al (1988) Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein. Proc Natl Acad Sci U S A 85:5434–5438PubMedCentralPubMedCrossRef
50.
Carabaza A, Ciudad CJ, Baque S, Guinovart JJ (1992) Glucose has to be phosphorylated to activate glycogen synthase, but not to inactivate glycogen phosphorylase in hepatocytes. FEBS Lett 296:211–214PubMedCrossRef
51.
Kabashima T, Kawaguchi T, Wadzinski BE, Uyeda K (2003) Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver. Proc Natl Acad Sci U S A 100:5107–5112PubMedCentralPubMedCrossRef
52.
Seyer P, Vallois D, Poitry-Yamate C et al (2013) Hepatic glucose sensing is required to preserve beta cell glucose competence. J Clin Invest 123:1662–1676PubMedCentralPubMedCrossRef
53.
Burcelin R, del Carmen MM, Guillam MT, Thorens B (2000) Liver hyperplasia and paradoxical regulation of glycogen metabolism and glucose-sensitive gene expression in GLUT2-null hepatocytes. Further evidence for the existence of a membrane-based glucose release pathway. J Biol Chem 275:10930–10936PubMedCrossRef
54.
Guillam MT, Burcelin R, Thorens B (1998) Normal hepatic glucose production in the absence of GLUT2 reveals an alternative pathway for glucose release from hepatocytes. Proc Natl Acad Sci U S A 95:12317–12321PubMedCentralPubMedCrossRef
55.
Hosokawa M, Thorens B (2002) Glucose release from GLUT2-null hepatocytes: characterization of a major and a minor pathway. Am J Physiol Endocrinol Metab 282:E794–E801PubMed
56.
Düfer M, Hörth K, Wagner R et al (2012) Bile acids acutely stimulate insulin secretion of mouse beta-cells via farnesoid X receptor activation and ATP-sensitive potassium channel inhibition. Diabetes 61:1479–1489PubMedCentralPubMedCrossRef
57.
Roncero I, Alvarez E, Chowen JA et al (2004) Expression of glucose transporter isoform GLUT-2 and glucokinase genes in human brain. J Neurochem 88:1203–1210PubMedCrossRef
58.
Liu Y, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX (2009) Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer’s disease. J Neurochem 111:242–249PubMedCentralPubMedCrossRef
59.
Castillo J, Crespo D, Capilla E et al (2009) Evolutionary structural and functional conservation of an ortholog of the GLUT2 glucose transporter gene (SLC2A2) in zebrafish. Am J Physiol Regul Integr Comp Physiol 297:R1570–R1581PubMedCrossRef
60.
Arluison M, Quignon M, Thorens B, Leloup C, Penicaud L (2004) Immunocytochemical localization of the glucose transporter 2 (GLUT2) in the adult rat brain. II. Electron microscopic study. J Chem Neuroanat 28:137–146PubMedCrossRef
61.
Arluison M, Quignon M, Nguyen P, Thorens B, Leloup C, Penicaud L (2004) Distribution and anatomical localization of the glucose transporter 2 (GLUT2) in the adult rat brain–an immunohistochemical study. J Chem Neuroanat 28:117–136PubMedCrossRef
62.
Garcia M, Millan C, Balmaceda-Aguilera C et al (2003) Hypothalamic ependymal-glial cells express the glucose transporter GLUT2, a protein involved in glucose sensing. J Neurochem 86:709–724PubMedCrossRef
63.
Mounien L, Marty N, Tarussio D et al (2010) Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons. FASEB J 24:1747–1758PubMedCrossRef
64.
Leloup C, Orosco M, Serradas P, Nicolaidis S, Penicaud L (1998) Specific inhibition of GLUT2 in arcuate nucleus by antisense oligonucleotides suppresses nervous control of insulin secretion. Brain Res Mol Brain Res 57:275–280PubMedCrossRef
65.
Wan HZ, Hulsey MG, Martin RJ (1998) Intracerebroventricular administration of antisense oligodeoxynucleotide against GLUT2 glucose transporter mRNA reduces food intake, body weight change and glucoprivic feeding response in rats. J Nutr 128:287–291PubMed
66.
Bady I, Marty N, Dallaporta M et al (2006) Evidence from glut2-null mice that glucose is a critical physiological regulator of feeding. Diabetes 55:988–995PubMedCrossRef
67.
Trumpp A, Depew MJ, Rubenstein JL, Bishop JM, Martin GR (1999) Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev 13:3136–3148PubMedCentralPubMedCrossRef
68.
Tarussio D, Metref S, Seyer P et al (2014) Nervous glucose sensing regulates postnatal beta cell proliferation and glucose homeostasis. J Clin Invest 124:413–424PubMedCentralPubMedCrossRef
69.
Finegood DT, Scaglia L, Bonner-Weir S (1995) Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 44:249–256PubMedCrossRef
70.
Girard J, Ferré P, Pégorier J-P, Duée P-H (1992) Adaptation of glucose and fatty acid metabolism during perinatal period and suckling-weaning transition. Physiol Rev 72:507–562PubMed
71.
Dallaporta M, Himmi T, Perrin J, Orsini JC (1999) Solitary tract nucleus sensitivity to moderate changes in glucose level. Neuroreport 10:2657–2660PubMedCrossRef
72.
Balfour RH, Hansen AM, Trapp S (2006) Neuronal responses to transient hypoglycaemia in the dorsal vagal complex of the rat brainstem. J Physiol 570:469–484PubMedCentralPubMedCrossRef
73.
Grill HJ, Hayes MR (2012) Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance. Cell Metab 16:296–309PubMedCrossRef
74.
Babic T, Browning KN, Travagli RA (2011) Differential organization of excitatory and inhibitory synapses within the rat dorsal vagal complex. Am J Physiol Gastrointest Liver Physiol 300:G21–G32PubMedCentralPubMedCrossRef
75.
Lamy CM, Sanno H, Labouèbe G et al (2014) Hypoglycemia-activated GLUT2 neurons of the nucleus tractus solitarius stimulate vagal activity and glucagon secretion. Cell Metab 19:527–538PubMedCrossRef
76.
Madisen L, Mao T, Koch H et al (2012) A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. Nat Neurosci 15:793–802PubMedCentralPubMedCrossRef
77.
Fenno L, Yizhar O, Deisseroth K (2011) The development and application of optogenetics. Annu Rev Neurosci 34:389–412PubMedCrossRef
78.
Taborsky GJ Jr, Mundinger TO (2012) Minireview: the role of the autonomic nervous system in mediating the glucagon response to hypoglycemia. Endocrinology 153:1055–1062PubMedCentralPubMedCrossRef
79.
80.
Fanconi G, Bickel H (1949) Die chronische Aminoacidurie bei der Glykogenose und der Cystinkrankheit. Helv Paediatr Acta 4:359–396, article in GermanPubMed
81.
Santer R, Schneppenheim R, Suter D, Schaub J, Steinmann B (1998) Fanconi-Bickel syndrome - the original patient and his natural history, historical steps leading to the primary defect, and a review of the literature. Eur J Pediatr 157:783–797PubMedCrossRef
82.
Foretz M, Thorens B (2003) The facilitative glucose transporter 2: pathophysiological role in mouse and human. In: Broër S, Wagner CA (eds) Membrane transporter diseases. Kluwer Academic/Plenum Publishers, New York, pp 175–190CrossRef
83.
Mannstadt M, Magen D, Segawa H et al (2012) Fanconi-Bickel syndrome and autosomal recessive proximal tubulopathy with hypercalciuria (ARPTH) Are allelic variants caused by GLUT2 mutations. J Clin Endocrinol Metab 97:E1978–E1986PubMedCentralPubMedCrossRef
84.
85.
Chesney RW, Kaplan BS, Colle E et al (1980) Abnormalities of carbohydrate metabolism in idiopathic Fanconi syndrome. Pediatr Res 14:209–215PubMedCrossRef
86.
Garty R, Cooper M, Tabachnik E (1974) The Fanconi syndrome associated with hepatic glycogenosis and abnormal metabolism of galactose. J Pediatr 85:821–823PubMedCrossRef
87.
Sansbury FH, Flanagan SE, Houghton JA et al (2012) SLC2A2 mutations can cause neonatal diabetes, suggesting GLUT2 may have a role in human insulin secretion. Diabetologia 55:2381–2385PubMedCrossRef
88.
Eny KM, Wolever TM, Fontaine-Bisson B, El-Sohemy A (2008) Genetic variant in the glucose transporter type 2 is associated with higher intakes of sugars in two distinct populations. Physiol Genomics 33:355–360PubMedCrossRef
89.
Mueckler M, Kruse M, Strube M, Riggs AC, Chiu KC, Permutt MA (1994) A mutation in the GLUT2 glucose transporter gene of a diabetic patient abolishes transport activity. J Biol Chem 269:17765–17767PubMed
90.
Dupuis J, Langenberg C, Prokopenko I et al (2010) New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 42:105–116PubMedCentralPubMedCrossRef
91.
Barker A, Sharp SJ, Timpson NJ et al (2011) Association of genetic loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children. Diabetes 60:1805–1812PubMedCentralPubMedCrossRef
92.
Gaulton KJ, Willer CJ, Li Y et al (2008) Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes. Diabetes 57:3136–3144PubMedCentralPubMedCrossRef
93.
Kilpelainen TO, Lakka TA, Laaksonen DE et al (2007) Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes. Physiol Genomics 31:264–272PubMedCrossRef
94.
Laukkanen O, Lindstrom J, Eriksson J et al (2005) Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study. Diabetes 54:2256–2260PubMedCrossRef
95.
Igl W, Johansson A, Wilson JF et al (2010) Modeling of environmental effects in genome-wide association studies identifies SLC2A2 and HP as novel loci influencing serum cholesterol levels. PLoS Genet 6:e1000798PubMedCentralPubMedCrossRef
96.
Borglykke A, Grarup N, Sparsø T et al (2012) Genetic variant SLC2A2 [corrected] is associated with risk of cardiovascular disease - assessing the individual and cumulative effect of 46 type 2 diabetes related genetic variants. PLoS One 7:e50418PubMedCentralPubMedCrossRef
97.
98.
Thorens B (2001) GLUT2 in pancreatic and extra-pancreatic gluco-detection (review). Mol Membr Biol 18:265–273PubMedCrossRef
99.
Stumpel F, Burcelin R, Jungermann K, Thorens B (2001) Normal kinetics of intestinal glucose absorption in the absence of GLUT2: evidence for a transport pathway requiring glucose phosphorylation and transfer into the endoplasmic reticulum. Proc Natl Acad Sci U S A 98:11330–11335PubMedCentralPubMedCrossRef
100.
Marty N, Dallaporta M, Foretz M et al (2005) Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors. J Clin Invest 115:3545–3553PubMedCentralPubMedCrossRef
Metadata
Title
GLUT2, glucose sensing and glucose homeostasis
Author
Bernard Thorens
Publication date
01-02-2015
Publisher
Springer Berlin Heidelberg
Published in
Diabetologia / Issue 2/2015
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-014-3451-1

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