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Published in: Diabetologia 6/2012

01-06-2012 | Position Statement

Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Authors: S. E. Inzucchi, R. M. Bergenstal, J. B. Buse, M. Diamant, E. Ferrannini, M. Nauck, A. L. Peters, A. Tsapas, R. Wender, D. R. Matthews

Published in: Diabetologia | Issue 6/2012

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Excerpt

Glycaemic management in type 2 diabetes mellitus has become increasingly complex and, to some extent, controversial, with a widening array of pharmacological agents now available [15], mounting concerns about their potential adverse effects and new uncertainties regarding the benefits of intensive glycaemic control on macrovascular complications [69]. Many clinicians are therefore perplexed as to the optimal strategies for their patients. As a consequence, the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) convened a joint task force to examine the evidence and develop recommendations for anti-hyperglycaemic therapy in non-pregnant adults with type 2 diabetes. Several guideline documents have been developed by members of these two organisations [10] and by other societies and federations [2, 1115]. However, an update was deemed necessary because of contemporary information on the benefits/risks of glycaemic control, recent evidence concerning efficacy and safety of several new drug classes [16, 17], the withdrawal/restriction of others and increasing calls for a move towards more patient-centred care [18, 19]. …
Appendix
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Literature
1.
go back to reference Bolen S, Feldman L, Vassy J et al (2007) Systematic review: comparative effectiveness and safety of oral medications for type 2 diabetes mellitus. Ann Intern Med 147:386–399PubMed Bolen S, Feldman L, Vassy J et al (2007) Systematic review: comparative effectiveness and safety of oral medications for type 2 diabetes mellitus. Ann Intern Med 147:386–399PubMed
2.
go back to reference Bergenstal RM, Bailey CJ, Kendall DM (2010) Type 2 diabetes: assessing the relative risks and benefits of glucose-lowering medications. Am J Med 123(374):e9–e18PubMed Bergenstal RM, Bailey CJ, Kendall DM (2010) Type 2 diabetes: assessing the relative risks and benefits of glucose-lowering medications. Am J Med 123(374):e9–e18PubMed
3.
go back to reference Nyenwe EA, Jerkins TW, Umpierrez GE, Kitabchi AE (2011) Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes. Metabolism 60:1–23PubMedCrossRef Nyenwe EA, Jerkins TW, Umpierrez GE, Kitabchi AE (2011) Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes. Metabolism 60:1–23PubMedCrossRef
4.
go back to reference Nolan JJ (2010) Consensus guidelines, algorithms and care of the individual patient with type 2 diabetes. Diabetologia 53:1247–1249PubMedCrossRef Nolan JJ (2010) Consensus guidelines, algorithms and care of the individual patient with type 2 diabetes. Diabetologia 53:1247–1249PubMedCrossRef
5.
go back to reference Blonde L (2010) Current antihyperglycemic treatment guidelines and algorithms for patients with type 2 diabetes mellitus. Am J Med 123(3 Suppl):S12–S18PubMedCrossRef Blonde L (2010) Current antihyperglycemic treatment guidelines and algorithms for patients with type 2 diabetes mellitus. Am J Med 123(3 Suppl):S12–S18PubMedCrossRef
6.
go back to reference Greenfield S, Billimek J, Pellegrini F et al (2009) Comorbidity affects the relationship between glycemic control and cardiovascular outcomes in diabetes: a cohort study. Ann Intern Med 151:854–860PubMed Greenfield S, Billimek J, Pellegrini F et al (2009) Comorbidity affects the relationship between glycemic control and cardiovascular outcomes in diabetes: a cohort study. Ann Intern Med 151:854–860PubMed
7.
go back to reference Matthews DR, Tsapas A (2008) Four decades of uncertainty: landmark trials in glycaemic control and cardiovascular outcome in type 2 diabetes. Diab Vasc Dis Res 5:216–218PubMedCrossRef Matthews DR, Tsapas A (2008) Four decades of uncertainty: landmark trials in glycaemic control and cardiovascular outcome in type 2 diabetes. Diab Vasc Dis Res 5:216–218PubMedCrossRef
8.
go back to reference Skyler JS, Bergenstal R, Bonow RO et al (2009) Intensive glycemic control and the prevention of cardiovascular events: implications of the ACCORD, ADVANCE, and VA diabetes trials: a position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association. Diabetes Care 32:187–192PubMedCrossRef Skyler JS, Bergenstal R, Bonow RO et al (2009) Intensive glycemic control and the prevention of cardiovascular events: implications of the ACCORD, ADVANCE, and VA diabetes trials: a position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association. Diabetes Care 32:187–192PubMedCrossRef
9.
go back to reference Yudkin JS, Richter B, Gale EA (2011) Intensified glucose control in type 2 diabetes—whose agenda? Lancet 377:1220–1222PubMedCrossRef Yudkin JS, Richter B, Gale EA (2011) Intensified glucose control in type 2 diabetes—whose agenda? Lancet 377:1220–1222PubMedCrossRef
10.
go back to reference Nathan DM, Buse JB, Davidson MB et al (2009) Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 52:17–30PubMedCrossRef Nathan DM, Buse JB, Davidson MB et al (2009) Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 52:17–30PubMedCrossRef
11.
go back to reference IDF Clinical Guidelines Task Force (2005) Global guideline for type 2 diabetes. International Diabetes Federation, Brussels IDF Clinical Guidelines Task Force (2005) Global guideline for type 2 diabetes. International Diabetes Federation, Brussels
12.
go back to reference Rodbard HW, Jellinger PS, Davidson JA et al (2009) Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel on type 2 diabetes mellitus: an algorithm for glycemic control. Endocr Pract 15:540–559PubMed Rodbard HW, Jellinger PS, Davidson JA et al (2009) Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel on type 2 diabetes mellitus: an algorithm for glycemic control. Endocr Pract 15:540–559PubMed
13.
go back to reference Berard LD, Booth G, Capes S, Quinn K, Woo V (2008) Canadian Diabetes Association 2008 clinical practice guidelines for the prevention and management of diabetes in Canada. Canadian Journal of Diabetes 32:S1–S201 Berard LD, Booth G, Capes S, Quinn K, Woo V (2008) Canadian Diabetes Association 2008 clinical practice guidelines for the prevention and management of diabetes in Canada. Canadian Journal of Diabetes 32:S1–S201
14.
go back to reference NICE (2009) Type 2 diabetes: the management of type 2 diabetes: NICE Clinical Guideline 87: National Institute for Health and Clinical Excellence NICE (2009) Type 2 diabetes: the management of type 2 diabetes: NICE Clinical Guideline 87: National Institute for Health and Clinical Excellence
15.
go back to reference Home P, Mant J, Diaz J, Turner C (2008) Management of type 2 diabetes: summary of updated NICE guidance. BMJ 336:1306–1308PubMedCrossRef Home P, Mant J, Diaz J, Turner C (2008) Management of type 2 diabetes: summary of updated NICE guidance. BMJ 336:1306–1308PubMedCrossRef
16.
go back to reference Davidson JA (2010) Incorporating incretin-based therapies into clinical practice: differences between glucagon-like Peptide 1 receptor agonists and dipeptidyl peptidase 4 inhibitors. Mayo Clin Proc 85:S27–S37PubMedCrossRef Davidson JA (2010) Incorporating incretin-based therapies into clinical practice: differences between glucagon-like Peptide 1 receptor agonists and dipeptidyl peptidase 4 inhibitors. Mayo Clin Proc 85:S27–S37PubMedCrossRef
17.
go back to reference DeFronzo RA (2010) Current issues in the treatment of type 2 diabetes. Overview of newer agents: where treatment is going. Am J Med 123:S38–S48PubMedCrossRef DeFronzo RA (2010) Current issues in the treatment of type 2 diabetes. Overview of newer agents: where treatment is going. Am J Med 123:S38–S48PubMedCrossRef
18.
go back to reference Murad MH, Shah ND, van Houten HK et al (2011) Individuals with diabetes preferred that future trials use patient-important outcomes and provide pragmatic inferences. J Clin Epidemiol 64:743–748PubMedCrossRef Murad MH, Shah ND, van Houten HK et al (2011) Individuals with diabetes preferred that future trials use patient-important outcomes and provide pragmatic inferences. J Clin Epidemiol 64:743–748PubMedCrossRef
19.
go back to reference Glasgow RE, Peeples M, Skovlund SE (2008) Where is the patient in diabetes performance measures? The case for including patient-centered and self-management measures. Diabetes Care 31:1046–1050PubMedCrossRef Glasgow RE, Peeples M, Skovlund SE (2008) Where is the patient in diabetes performance measures? The case for including patient-centered and self-management measures. Diabetes Care 31:1046–1050PubMedCrossRef
20.
go back to reference Ismail-Beigi F, Moghissi E, Tiktin M, Hirsch IB, Inzucchi SE, Genuth S (2011) Individualizing glycemic targets in type 2 diabetes mellitus: implications of recent clinical trials. Ann Intern Med 154:554–559PubMed Ismail-Beigi F, Moghissi E, Tiktin M, Hirsch IB, Inzucchi SE, Genuth S (2011) Individualizing glycemic targets in type 2 diabetes mellitus: implications of recent clinical trials. Ann Intern Med 154:554–559PubMed
21.
go back to reference Mullan RJ, Montori VM, Shah ND et al (2009) The diabetes mellitus medication choice decision aid: a randomized trial. Arch Intern Med 169:1560–1568PubMedCrossRef Mullan RJ, Montori VM, Shah ND et al (2009) The diabetes mellitus medication choice decision aid: a randomized trial. Arch Intern Med 169:1560–1568PubMedCrossRef
22.
go back to reference Schernthaner G, Barnett AH, Betteridge DJ et al (2010) Is the ADA/EASD algorithm for the management of type 2 diabetes (January 2009) based on evidence or opinion? A critical analysis. Diabetologia 53:1258–1269PubMedCrossRef Schernthaner G, Barnett AH, Betteridge DJ et al (2010) Is the ADA/EASD algorithm for the management of type 2 diabetes (January 2009) based on evidence or opinion? A critical analysis. Diabetologia 53:1258–1269PubMedCrossRef
23.
go back to reference Gandhi GY, Murad MH, Fujiyoshi A et al (2008) Patient-important outcomes in registered diabetes trials. JAMA 299:2543–2549PubMedCrossRef Gandhi GY, Murad MH, Fujiyoshi A et al (2008) Patient-important outcomes in registered diabetes trials. JAMA 299:2543–2549PubMedCrossRef
24.
go back to reference Smith RJ, Nathan DM, Arslanian SA, Groop L, Rizza RA, Rotter JI (2010) Individualizing therapies in type 2 diabetes mellitus based on patient characteristics: what we know and what we need to know. J Clin Endocrinol Metab 95:1566–1574PubMedCrossRef Smith RJ, Nathan DM, Arslanian SA, Groop L, Rizza RA, Rotter JI (2010) Individualizing therapies in type 2 diabetes mellitus based on patient characteristics: what we know and what we need to know. J Clin Endocrinol Metab 95:1566–1574PubMedCrossRef
25.
go back to reference Committee on Quality of Health Care in America: Institute of Medicine (2001) Crossing the quality chasm: a new health system for the 21st century. The National Academies Press, Washington Committee on Quality of Health Care in America: Institute of Medicine (2001) Crossing the quality chasm: a new health system for the 21st century. The National Academies Press, Washington
26.
go back to reference Guyatt GH, Haynes RB, Jaeschke RZ, Cook DJ, Green L, Naylor CD et al (2000) Users’ Guides to the Medical Literature: XXV. Evidence-based medicine: principles for applying the Users’ Guides to patient care. Evidence-Based Medicine Working Group. JAMA 284:1290–1296PubMedCrossRef Guyatt GH, Haynes RB, Jaeschke RZ, Cook DJ, Green L, Naylor CD et al (2000) Users’ Guides to the Medical Literature: XXV. Evidence-based medicine: principles for applying the Users’ Guides to patient care. Evidence-Based Medicine Working Group. JAMA 284:1290–1296PubMedCrossRef
27.
go back to reference Tsapas A, Matthews DR (2008) N of 1 trials in diabetes: making individual therapeutic decisions. Diabetologia 51:921–925PubMedCrossRef Tsapas A, Matthews DR (2008) N of 1 trials in diabetes: making individual therapeutic decisions. Diabetologia 51:921–925PubMedCrossRef
28.
go back to reference Shah ND, Mullan RJ, Breslin M, Yawn BP, Ting HH, Montori VM (2010) Translating comparative effectiveness into practice: the case of diabetes medications. Med Care 48:S153–S158PubMedCrossRef Shah ND, Mullan RJ, Breslin M, Yawn BP, Ting HH, Montori VM (2010) Translating comparative effectiveness into practice: the case of diabetes medications. Med Care 48:S153–S158PubMedCrossRef
29.
go back to reference Stratton IM, Adler AI, Neil HA et al (2000) Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 321:405–412PubMedCrossRef Stratton IM, Adler AI, Neil HA et al (2000) Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 321:405–412PubMedCrossRef
30.
go back to reference Turner RC, Holman RR, Cull CA et al (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352:837–853CrossRef Turner RC, Holman RR, Cull CA et al (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352:837–853CrossRef
31.
go back to reference UKPDS Group (1991) UK Prospective Diabetes Study VIII: study design, progress and performance. Diabetologia 34:877–890CrossRef UKPDS Group (1991) UK Prospective Diabetes Study VIII: study design, progress and performance. Diabetologia 34:877–890CrossRef
32.
go back to reference Turner RC, Holman RR, Cull CA et al (1998) Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352:854–865CrossRef Turner RC, Holman RR, Cull CA et al (1998) Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 352:854–865CrossRef
33.
go back to reference Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA (2008) 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 359:1577–1589PubMedCrossRef Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA (2008) 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 359:1577–1589PubMedCrossRef
34.
go back to reference Gerstein HC, Miller ME, Byington RP et al (2008) Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 358:2545–2559PubMedCrossRef Gerstein HC, Miller ME, Byington RP et al (2008) Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 358:2545–2559PubMedCrossRef
35.
go back to reference Patel A, MacMahon S, Chalmers J et al (2008) Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 358:2560–2572PubMedCrossRef Patel A, MacMahon S, Chalmers J et al (2008) Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 358:2560–2572PubMedCrossRef
36.
go back to reference Turnbull FM, Abraira C, Anderson RJ, Byington RP, Chalmers JP, Duckworth WC et al (2009) Intensive glucose control and macrovascular outcomes in type 2 diabetes. Diabetologia 52:2288–2298, Erratum 52:2470PubMedCrossRef Turnbull FM, Abraira C, Anderson RJ, Byington RP, Chalmers JP, Duckworth WC et al (2009) Intensive glucose control and macrovascular outcomes in type 2 diabetes. Diabetologia 52:2288–2298, Erratum 52:2470PubMedCrossRef
37.
go back to reference Ferrannini E, Gastaldelli A, Miyazaki Y, Matsuda M, Mari A, DeFronzo RA (2005) Beta-cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis. J Clin Endocrinol Metab 90:493–500PubMedCrossRef Ferrannini E, Gastaldelli A, Miyazaki Y, Matsuda M, Mari A, DeFronzo RA (2005) Beta-cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis. J Clin Endocrinol Metab 90:493–500PubMedCrossRef
38.
go back to reference Nauck MA (2011) Incretin-based therapies for type 2 diabetes mellitus: properties, functions, and clinical implications. Am J Med 124:S3–S18PubMedCrossRef Nauck MA (2011) Incretin-based therapies for type 2 diabetes mellitus: properties, functions, and clinical implications. Am J Med 124:S3–S18PubMedCrossRef
41.
go back to reference Groop LC, Ferrannini E (1993) Insulin action and substrate competition. Baillieres Clin Endocrinol Metab 7:1007–1032PubMedCrossRef Groop LC, Ferrannini E (1993) Insulin action and substrate competition. Baillieres Clin Endocrinol Metab 7:1007–1032PubMedCrossRef
42.
go back to reference ADA (2011) Standards of medical care in diabetes–2011. Diabetes Care 34(Suppl 1):S11–S61 ADA (2011) Standards of medical care in diabetes–2011. Diabetes Care 34(Suppl 1):S11–S61
43.
go back to reference Akalin S, Berntorp K, Ceriello A et al (2009) Intensive glucose therapy and clinical implications of recent data: a consensus statement from the Global Task Force on Glycaemic Control. Int J Clin Pract 63:1421–1425PubMedCrossRef Akalin S, Berntorp K, Ceriello A et al (2009) Intensive glucose therapy and clinical implications of recent data: a consensus statement from the Global Task Force on Glycaemic Control. Int J Clin Pract 63:1421–1425PubMedCrossRef
44.
go back to reference Lee SJ, Eng C (2011) Goals of glycemic control in frail older patients with diabetes. JAMA 305:1350–1351PubMedCrossRef Lee SJ, Eng C (2011) Goals of glycemic control in frail older patients with diabetes. JAMA 305:1350–1351PubMedCrossRef
45.
go back to reference Ahmed MH, Byrne CD (2009) Current treatment of non-alcoholic fatty liver disease. Diabetes Obes Metab 11:188–195PubMedCrossRef Ahmed MH, Byrne CD (2009) Current treatment of non-alcoholic fatty liver disease. Diabetes Obes Metab 11:188–195PubMedCrossRef
47.
go back to reference Anderson JW, Kendall CW, Jenkins DJ (2003) Importance of weight management in type 2 diabetes: review with meta-analysis of clinical studies. J Am Coll Nutr 22:331–339PubMed Anderson JW, Kendall CW, Jenkins DJ (2003) Importance of weight management in type 2 diabetes: review with meta-analysis of clinical studies. J Am Coll Nutr 22:331–339PubMed
48.
go back to reference Klein S, Sheard NF, Pi-Sunyer X et al (2004) Weight management through lifestyle modification for the prevention and management of type 2 diabetes: rationale and strategies: a statement of the American Diabetes Association, the North American Association for the Study of Obesity, and the American Society for Clinical Nutrition. Diabetes Care 27:2067–2073PubMedCrossRef Klein S, Sheard NF, Pi-Sunyer X et al (2004) Weight management through lifestyle modification for the prevention and management of type 2 diabetes: rationale and strategies: a statement of the American Diabetes Association, the North American Association for the Study of Obesity, and the American Society for Clinical Nutrition. Diabetes Care 27:2067–2073PubMedCrossRef
49.
go back to reference Bantle JP, Wylie-Rosett J, Albright AL et al (2008) Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association. Diabetes Care 31(Suppl 1):S61–S78PubMed Bantle JP, Wylie-Rosett J, Albright AL et al (2008) Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association. Diabetes Care 31(Suppl 1):S61–S78PubMed
50.
go back to reference Elmer PJ, Obarzanek E, Vollmer WM et al (2006) Effects of comprehensive lifestyle modification on diet, weight, physical fitness, and blood pressure control: 18-month results of a randomized trial. Ann Intern Med 144:485–495PubMed Elmer PJ, Obarzanek E, Vollmer WM et al (2006) Effects of comprehensive lifestyle modification on diet, weight, physical fitness, and blood pressure control: 18-month results of a randomized trial. Ann Intern Med 144:485–495PubMed
51.
go back to reference Gordon NF, Salmon RD, Franklin BA et al (2004) Effectiveness of therapeutic lifestyle changes in patients with hypertension, hyperlipidemia, and/or hyperglycemia. Am J Cardiol 94:1558–1561PubMedCrossRef Gordon NF, Salmon RD, Franklin BA et al (2004) Effectiveness of therapeutic lifestyle changes in patients with hypertension, hyperlipidemia, and/or hyperglycemia. Am J Cardiol 94:1558–1561PubMedCrossRef
52.
go back to reference Wing RR, Tate DF, Gorin AA, Raynor HA, Fava JL (2006) A self-regulation program for maintenance of weight loss. N Engl J Med 355:1563–1571PubMedCrossRef Wing RR, Tate DF, Gorin AA, Raynor HA, Fava JL (2006) A self-regulation program for maintenance of weight loss. N Engl J Med 355:1563–1571PubMedCrossRef
53.
go back to reference Boule NG, Haddad E, Kenny GP, Wells GA, Sigal RJ (2001) Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA 286:1218–1227PubMedCrossRef Boule NG, Haddad E, Kenny GP, Wells GA, Sigal RJ (2001) Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA 286:1218–1227PubMedCrossRef
55.
go back to reference Lamanna C, Monami M, Marchionni N, Mannucci E (2011) Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials. Diabetes Obes Metab 13:221–228PubMedCrossRef Lamanna C, Monami M, Marchionni N, Mannucci E (2011) Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials. Diabetes Obes Metab 13:221–228PubMedCrossRef
56.
go back to reference Bryan J, Crane A, Vila-Carriles WH, Babenko AP, Aguilar-Bryan L (2005) Insulin secretagogues, sulfonylurea receptors and K(ATP) channels. Curr Pharm Des 11:2699–2716PubMedCrossRef Bryan J, Crane A, Vila-Carriles WH, Babenko AP, Aguilar-Bryan L (2005) Insulin secretagogues, sulfonylurea receptors and K(ATP) channels. Curr Pharm Des 11:2699–2716PubMedCrossRef
57.
go back to reference Kahn SE, Haffner SM, Heise MA, Herman WH, Holman RR, Jones NP et al (2006) Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med 355:2427–2443PubMedCrossRef Kahn SE, Haffner SM, Heise MA, Herman WH, Holman RR, Jones NP et al (2006) Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med 355:2427–2443PubMedCrossRef
58.
go back to reference Gerich J, Raskin P, Jean-Louis L, Purkayastha D, Baron MA (2005) PRESERVE-β: two-year efficacy and safety of initial combination therapy with nateglinide or glyburide plus metformin. Diabetes Care 28:2093–2099PubMedCrossRef Gerich J, Raskin P, Jean-Louis L, Purkayastha D, Baron MA (2005) PRESERVE-β: two-year efficacy and safety of initial combination therapy with nateglinide or glyburide plus metformin. Diabetes Care 28:2093–2099PubMedCrossRef
60.
go back to reference Dormandy JA, Charbonnel B, Eckland DJ et al (2005) Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 366:1279–1289PubMedCrossRef Dormandy JA, Charbonnel B, Eckland DJ et al (2005) Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 366:1279–1289PubMedCrossRef
61.
go back to reference Nissen SE, Wolski K (2010) Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality. Arch Intern Med 170:1191–1201PubMedCrossRef Nissen SE, Wolski K (2010) Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortality. Arch Intern Med 170:1191–1201PubMedCrossRef
62.
go back to reference Lewis JD, Ferrara A, Peng T et al (2011) Risk of bladder cancer among diabetic patients treated with pioglitazone: interim report of a longitudinal cohort study. Diabetes Care 34:916–922PubMedCrossRef Lewis JD, Ferrara A, Peng T et al (2011) Risk of bladder cancer among diabetic patients treated with pioglitazone: interim report of a longitudinal cohort study. Diabetes Care 34:916–922PubMedCrossRef
63.
go back to reference Drucker DJ, Nauck MA (2006) The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 368:1696–1705PubMedCrossRef Drucker DJ, Nauck MA (2006) The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 368:1696–1705PubMedCrossRef
64.
go back to reference Deacon CF (2011) Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review. Diabetes Obes Metab 13:7–18PubMedCrossRef Deacon CF (2011) Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review. Diabetes Obes Metab 13:7–18PubMedCrossRef
65.
go back to reference Van de Laar FA, Lucassen PL, Akkermans RP, van de Lisdonk EH, de Grauw WJ (2006) Alpha-glucosidase inhibitors for people with impaired glucose tolerance or impaired fasting blood glucose. Cochrane Database Syst Rev. Issue 4. Art. no.: CD005061. doi:10.1002/14651858.CD005061.pub2 Van de Laar FA, Lucassen PL, Akkermans RP, van de Lisdonk EH, de Grauw WJ (2006) Alpha-glucosidase inhibitors for people with impaired glucose tolerance or impaired fasting blood glucose. Cochrane Database Syst Rev. Issue 4. Art. no.: CD005061. doi:10.​1002/​14651858.​CD005061.​pub2
66.
go back to reference Fonseca VA, Handelsman Y, Staels B (2010) Colesevelam lowers glucose and lipid levels in type 2 diabetes: the clinical evidence. Diabetes Obes Metab 12:384–392PubMedCrossRef Fonseca VA, Handelsman Y, Staels B (2010) Colesevelam lowers glucose and lipid levels in type 2 diabetes: the clinical evidence. Diabetes Obes Metab 12:384–392PubMedCrossRef
67.
go back to reference Defronzo RA (2011) Bromocriptine: a sympatholytic, D2-dopamine agonist for the treatment of type 2 diabetes. Diabetes Care 34:789–794PubMedCrossRef Defronzo RA (2011) Bromocriptine: a sympatholytic, D2-dopamine agonist for the treatment of type 2 diabetes. Diabetes Care 34:789–794PubMedCrossRef
68.
go back to reference Singh-Franco D, Robles G, Gazze D (2007) Pramlintide acetate injection for the treatment of type 1 and type 2 diabetes mellitus. Clin Ther 29:535–562PubMedCrossRef Singh-Franco D, Robles G, Gazze D (2007) Pramlintide acetate injection for the treatment of type 1 and type 2 diabetes mellitus. Clin Ther 29:535–562PubMedCrossRef
69.
go back to reference Peters A (2010) Incretin-based therapies: review of current clinical trial data. Am J Med 123:S28–S37PubMedCrossRef Peters A (2010) Incretin-based therapies: review of current clinical trial data. Am J Med 123:S28–S37PubMedCrossRef
70.
go back to reference Bennett WL, Maruthur NM, Singh S et al (2011) Comparative effectiveness and safety of medications for type 2 diabetes: an update including new drugs and 2-drug combinations. Ann Intern Med 154:602–613PubMed Bennett WL, Maruthur NM, Singh S et al (2011) Comparative effectiveness and safety of medications for type 2 diabetes: an update including new drugs and 2-drug combinations. Ann Intern Med 154:602–613PubMed
71.
go back to reference Jabbour S (2008) Primary care physicians and insulin initiation: multiple barriers, lack of knowledge or both? Int J Clin Pract 62:845–847PubMedCrossRef Jabbour S (2008) Primary care physicians and insulin initiation: multiple barriers, lack of knowledge or both? Int J Clin Pract 62:845–847PubMedCrossRef
72.
go back to reference Bergenstal RM, Johnson M, Powers MA et al (2008) Adjust to target in type 2 diabetes: comparison of a simple algorithm with carbohydrate counting for adjustment of mealtime insulin glulisine. Diabetes Care 31:1305–1310PubMedCrossRef Bergenstal RM, Johnson M, Powers MA et al (2008) Adjust to target in type 2 diabetes: comparison of a simple algorithm with carbohydrate counting for adjustment of mealtime insulin glulisine. Diabetes Care 31:1305–1310PubMedCrossRef
73.
go back to reference Cryer PE (2002) Hypoglycaemia: the limiting factor in the glycaemic management of type I and type II diabetes. Diabetologia 45:937–948PubMedCrossRef Cryer PE (2002) Hypoglycaemia: the limiting factor in the glycaemic management of type I and type II diabetes. Diabetologia 45:937–948PubMedCrossRef
74.
go back to reference Holman RR, Farmer AJ, Davies MJ et al (2009) Three-year efficacy of complex insulin regimens in type 2 diabetes. N Engl J Med 361:1736–1747PubMedCrossRef Holman RR, Farmer AJ, Davies MJ et al (2009) Three-year efficacy of complex insulin regimens in type 2 diabetes. N Engl J Med 361:1736–1747PubMedCrossRef
75.
go back to reference Hermansen K, Davies M, Derezinski T, Martinez Ravn G, Clauson P, Home P (2006) A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetes. Diabetes Care 29:1269–1274PubMedCrossRef Hermansen K, Davies M, Derezinski T, Martinez Ravn G, Clauson P, Home P (2006) A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetes. Diabetes Care 29:1269–1274PubMedCrossRef
76.
go back to reference Riddle MC (2006) The Treat-to-Target Trial and related studies. Endocr Pract 12(Suppl 1):71–79PubMed Riddle MC (2006) The Treat-to-Target Trial and related studies. Endocr Pract 12(Suppl 1):71–79PubMed
77.
go back to reference Rosenstock J, Davies M, Home PD, Larsen J, Koenen C, Schernthaner G (2008) A randomised, 52-week, treat-to-target trial comparing insulin detemir with insulin glargine when administered as add-on to glucose-lowering drugs in insulin-naive people with type 2 diabetes. Diabetologia 51:408–416PubMedCrossRef Rosenstock J, Davies M, Home PD, Larsen J, Koenen C, Schernthaner G (2008) A randomised, 52-week, treat-to-target trial comparing insulin detemir with insulin glargine when administered as add-on to glucose-lowering drugs in insulin-naive people with type 2 diabetes. Diabetologia 51:408–416PubMedCrossRef
78.
go back to reference Simonson GD, Cuddihy RM, Reader D, Bergenstal RM (2011) International Diabetes Center treatment of type 2 diabetes glucose algorithm. Diabetes Management 1:175–189CrossRef Simonson GD, Cuddihy RM, Reader D, Bergenstal RM (2011) International Diabetes Center treatment of type 2 diabetes glucose algorithm. Diabetes Management 1:175–189CrossRef
79.
go back to reference Gross JL, Kramer CK, Leitao CB et al (2011) Effect of antihyperglycemic agents added to metformin and a sulfonylurea on glycemic control and weight gain in type 2 diabetes: a network meta-analysis. Ann Intern Med 154:672–679PubMed Gross JL, Kramer CK, Leitao CB et al (2011) Effect of antihyperglycemic agents added to metformin and a sulfonylurea on glycemic control and weight gain in type 2 diabetes: a network meta-analysis. Ann Intern Med 154:672–679PubMed
80.
go back to reference Karagiannis T, Paschos P, Paletas P, Matthews DR, Tsapas A (2012) Dipeptidyl peptidase-4 inhibitors for type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis. BMJ 344:e1369PubMedCrossRef Karagiannis T, Paschos P, Paletas P, Matthews DR, Tsapas A (2012) Dipeptidyl peptidase-4 inhibitors for type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis. BMJ 344:e1369PubMedCrossRef
81.
go back to reference Cryer PE (2007) Severe iatrogenic hypoglycemia in type 2 diabetes mellitus. Nat Clin Pract Endocrinol Metab 3:4–5PubMedCrossRef Cryer PE (2007) Severe iatrogenic hypoglycemia in type 2 diabetes mellitus. Nat Clin Pract Endocrinol Metab 3:4–5PubMedCrossRef
82.
go back to reference Loke YK, Kwok CS, Singh S (2011) Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies. BMJ 342:d1309PubMedCrossRef Loke YK, Kwok CS, Singh S (2011) Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies. BMJ 342:d1309PubMedCrossRef
83.
go back to reference Kendall DM, Riddle MC, Rosenstock J et al (2005) Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care 28:1083–1091PubMedCrossRef Kendall DM, Riddle MC, Rosenstock J et al (2005) Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care 28:1083–1091PubMedCrossRef
84.
go back to reference Zinman B, Gerich J, Buse JB et al (2009) Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care 32:1224–1230PubMedCrossRef Zinman B, Gerich J, Buse JB et al (2009) Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care 32:1224–1230PubMedCrossRef
85.
go back to reference Roberts VL, Stewart J, Issa M, Lake B, Melis R (2005) Triple therapy with glimepiride in patients with type 2 diabetes mellitus inadequately controlled by metformin and a thiazolidinedione: results of a 30-week, randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther 27:1535–1547PubMedCrossRef Roberts VL, Stewart J, Issa M, Lake B, Melis R (2005) Triple therapy with glimepiride in patients with type 2 diabetes mellitus inadequately controlled by metformin and a thiazolidinedione: results of a 30-week, randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther 27:1535–1547PubMedCrossRef
86.
go back to reference Bell DS, Dharmalingam M, Kumar S, Sawakhande RB (2011) Triple oral fixed-dose diabetes polypill versus insulin plus metformin efficacy demonstration study in the treatment of advanced type 2 diabetes (TrIED study-II). Diabetes Obes Metab 13:800–805PubMedCrossRef Bell DS, Dharmalingam M, Kumar S, Sawakhande RB (2011) Triple oral fixed-dose diabetes polypill versus insulin plus metformin efficacy demonstration study in the treatment of advanced type 2 diabetes (TrIED study-II). Diabetes Obes Metab 13:800–805PubMedCrossRef
87.
go back to reference Rosenstock J, Sugimoto D, Strange P, Stewart JA, Soltes-Rak E, Dailey G (2006) Triple therapy in type 2 diabetes: insulin glargine or rosiglitazone added to combination therapy of sulfonylurea plus metformin in insulin-naive patients. Diabetes Care 29:554–559PubMedCrossRef Rosenstock J, Sugimoto D, Strange P, Stewart JA, Soltes-Rak E, Dailey G (2006) Triple therapy in type 2 diabetes: insulin glargine or rosiglitazone added to combination therapy of sulfonylurea plus metformin in insulin-naive patients. Diabetes Care 29:554–559PubMedCrossRef
88.
go back to reference Yki-Jarvinen H, Juurinen L, Alvarsson M et al (2007) Initiate Insulin by Aggressive Titration and Education (INITIATE): a randomized study to compare initiation of insulin combination therapy in type 2 diabetic patients individually and in groups. Diabetes Care 30:1364–1369PubMedCrossRef Yki-Jarvinen H, Juurinen L, Alvarsson M et al (2007) Initiate Insulin by Aggressive Titration and Education (INITIATE): a randomized study to compare initiation of insulin combination therapy in type 2 diabetic patients individually and in groups. Diabetes Care 30:1364–1369PubMedCrossRef
89.
go back to reference Davies M, Storms F, Shutler S, Bianchi-Biscay M, Gomis R (2005) Improvement of glycemic control in subjects with poorly controlled type 2 diabetes: comparison of two treatment algorithms using insulin glargine. Diabetes Care 28:1282–1288PubMedCrossRef Davies M, Storms F, Shutler S, Bianchi-Biscay M, Gomis R (2005) Improvement of glycemic control in subjects with poorly controlled type 2 diabetes: comparison of two treatment algorithms using insulin glargine. Diabetes Care 28:1282–1288PubMedCrossRef
90.
go back to reference Garber AJ (2009) The importance of titrating starting insulin regimens in patients with type 2 diabetes. Diabetes Obes Metab 11(Suppl 5):10–13PubMedCrossRef Garber AJ (2009) The importance of titrating starting insulin regimens in patients with type 2 diabetes. Diabetes Obes Metab 11(Suppl 5):10–13PubMedCrossRef
91.
go back to reference Owens DR, Luzio SD, Sert-Langeron C, Riddle MC (2011) Effects of initiation and titration of a single pre-prandial dose of insulin glulisine while continuing titrated insulin glargine in type 2 diabetes: a 6-month ‘proof-of-concept’ study. Diabetes Obes Metab 13:1020–1027PubMedCrossRef Owens DR, Luzio SD, Sert-Langeron C, Riddle MC (2011) Effects of initiation and titration of a single pre-prandial dose of insulin glulisine while continuing titrated insulin glargine in type 2 diabetes: a 6-month ‘proof-of-concept’ study. Diabetes Obes Metab 13:1020–1027PubMedCrossRef
92.
go back to reference Davidson MB, Raskin P, Tanenberg RJ, Vlajnic A, Hollander P (2011) A stepwise approach to insulin therapy in patients with type 2 diabetes mellitus and basal insulin treatment failure. Endocr Pract 17:395–403PubMedCrossRef Davidson MB, Raskin P, Tanenberg RJ, Vlajnic A, Hollander P (2011) A stepwise approach to insulin therapy in patients with type 2 diabetes mellitus and basal insulin treatment failure. Endocr Pract 17:395–403PubMedCrossRef
93.
go back to reference Raccah D (2008) Options for the intensification of insulin therapy when basal insulin is not enough in type 2 diabetes mellitus. Diabetes Obes Metab 10(Suppl 2):76–82PubMedCrossRef Raccah D (2008) Options for the intensification of insulin therapy when basal insulin is not enough in type 2 diabetes mellitus. Diabetes Obes Metab 10(Suppl 2):76–82PubMedCrossRef
94.
go back to reference Ilag LL, Kerr L, Malone JK, Tan MH (2007) Prandial premixed insulin analogue regimens versus basal insulin analogue regimens in the management of type 2 diabetes: an evidence-based comparison. Clin Ther 29:1254–1270CrossRef Ilag LL, Kerr L, Malone JK, Tan MH (2007) Prandial premixed insulin analogue regimens versus basal insulin analogue regimens in the management of type 2 diabetes: an evidence-based comparison. Clin Ther 29:1254–1270CrossRef
95.
go back to reference Aviles-Santa L, Sinding J, Raskin P (1999) Effects of metformin in patients with poorly controlled, insulin-treated type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 131:182–188PubMed Aviles-Santa L, Sinding J, Raskin P (1999) Effects of metformin in patients with poorly controlled, insulin-treated type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 131:182–188PubMed
96.
go back to reference Strowig SM, Raskin P (2005) Combination therapy using metformin or thiazolidinediones and insulin in the treatment of diabetes mellitus. Diabetes Obes Metab 7:633–641PubMedCrossRef Strowig SM, Raskin P (2005) Combination therapy using metformin or thiazolidinediones and insulin in the treatment of diabetes mellitus. Diabetes Obes Metab 7:633–641PubMedCrossRef
97.
go back to reference Buse JB (2011) Type 2 diabetes mellitus in 2010: individualizing treatment targets in diabetes care. Nat Rev Endocrinol 7:67–68PubMedCrossRef Buse JB (2011) Type 2 diabetes mellitus in 2010: individualizing treatment targets in diabetes care. Nat Rev Endocrinol 7:67–68PubMedCrossRef
98.
go back to reference Vilsboll T, Rosenstock J, Yki-Jarvinen H et al (2010) Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes. Diabetes Obes Metab 12:167–177PubMedCrossRef Vilsboll T, Rosenstock J, Yki-Jarvinen H et al (2010) Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes. Diabetes Obes Metab 12:167–177PubMedCrossRef
99.
go back to reference Del Prato S, Heine RJ, Keilson L, Guitard C, Shen SG, Emmons RP (2003) Treatment of patients over 64 years of age with type 2 diabetes: experience from nateglinide pooled database retrospective analysis. Diabetes Care 26:2075–2080PubMedCrossRef Del Prato S, Heine RJ, Keilson L, Guitard C, Shen SG, Emmons RP (2003) Treatment of patients over 64 years of age with type 2 diabetes: experience from nateglinide pooled database retrospective analysis. Diabetes Care 26:2075–2080PubMedCrossRef
100.
go back to reference Booth GL, Kapral MK, Fung K, Tu JV (2006) Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study. Lancet 368:29–36PubMedCrossRef Booth GL, Kapral MK, Fung K, Tu JV (2006) Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study. Lancet 368:29–36PubMedCrossRef
101.
go back to reference Nelson JM, Dufraux K, Cook PF (2007) The relationship between glycemic control and falls in older adults. J Am Geriatr Soc 55:2041–2044PubMedCrossRef Nelson JM, Dufraux K, Cook PF (2007) The relationship between glycemic control and falls in older adults. J Am Geriatr Soc 55:2041–2044PubMedCrossRef
102.
go back to reference Sluik D, Boeing H, Montonen J et al (2011) Associations between general and abdominal adiposity and mortality in individuals with diabetes mellitus. Am J Epidemiol 174:22–34PubMedCrossRef Sluik D, Boeing H, Montonen J et al (2011) Associations between general and abdominal adiposity and mortality in individuals with diabetes mellitus. Am J Epidemiol 174:22–34PubMedCrossRef
103.
go back to reference Unick JL, Beavers D, Jakicic JM et al (2011) Effectiveness of lifestyle interventions for individuals with severe obesity and type 2 diabetes: results from the Look AHEAD trial. Diabetes Care 34:2152–2157PubMedCrossRef Unick JL, Beavers D, Jakicic JM et al (2011) Effectiveness of lifestyle interventions for individuals with severe obesity and type 2 diabetes: results from the Look AHEAD trial. Diabetes Care 34:2152–2157PubMedCrossRef
104.
go back to reference Krentz AJ, Bailey CJ (2005) Oral antidiabetic agents: current role in type 2 diabetes mellitus. Drugs 65:385–411PubMedCrossRef Krentz AJ, Bailey CJ (2005) Oral antidiabetic agents: current role in type 2 diabetes mellitus. Drugs 65:385–411PubMedCrossRef
105.
go back to reference Buchwald H, Estok R, Fahrbach K et al (2009) Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med 122:248–256, e5PubMedCrossRef Buchwald H, Estok R, Fahrbach K et al (2009) Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med 122:248–256, e5PubMedCrossRef
106.
go back to reference Davis TM, Wright AD, Mehta ZM et al (2005) Islet autoantibodies in clinically diagnosed type 2 diabetes: prevalence and relationship with metabolic control (UKPDS 70). Diabetologia 48:695–702PubMedCrossRef Davis TM, Wright AD, Mehta ZM et al (2005) Islet autoantibodies in clinically diagnosed type 2 diabetes: prevalence and relationship with metabolic control (UKPDS 70). Diabetologia 48:695–702PubMedCrossRef
107.
go back to reference Park YW, Zhu S, Palaniappan L, Heshka S, Carnethon MR, Heymsfield SB (2003) The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch Intern Med 163:427–436PubMedCrossRef Park YW, Zhu S, Palaniappan L, Heshka S, Carnethon MR, Heymsfield SB (2003) The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch Intern Med 163:427–436PubMedCrossRef
108.
go back to reference Chen KW, Boyko EJ, Bergstrom RW et al (1995) Earlier appearance of impaired insulin secretion than of visceral adiposity in the pathogenesis of NIDDM. 5-Year follow-up of initially nondiabetic Japanese-American men. Diabetes Care 18:747–753PubMedCrossRef Chen KW, Boyko EJ, Bergstrom RW et al (1995) Earlier appearance of impaired insulin secretion than of visceral adiposity in the pathogenesis of NIDDM. 5-Year follow-up of initially nondiabetic Japanese-American men. Diabetes Care 18:747–753PubMedCrossRef
109.
go back to reference Kahn SE (2003) The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 46:3–19PubMedCrossRef Kahn SE (2003) The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 46:3–19PubMedCrossRef
110.
go back to reference Malecki MT, Mlynarski W (2008) Monogenic diabetes: implications for therapy of rare types of disease. Diabetes Obes Metab 10:607–616PubMedCrossRef Malecki MT, Mlynarski W (2008) Monogenic diabetes: implications for therapy of rare types of disease. Diabetes Obes Metab 10:607–616PubMedCrossRef
111.
go back to reference Nordin C (2010) The case for hypoglycaemia as a proarrhythmic event: basic and clinical evidence. Diabetologia 53:1552–1561PubMedCrossRef Nordin C (2010) The case for hypoglycaemia as a proarrhythmic event: basic and clinical evidence. Diabetologia 53:1552–1561PubMedCrossRef
112.
go back to reference Riveline JP, Danchin N, Ledru F, Varroud-Vial M, Charpentier G (2003) Sulfonylureas and cardiovascular effects: from experimental data to clinical use. Available data in humans and clinical applications. Diabetes Metab 29:207–222PubMedCrossRef Riveline JP, Danchin N, Ledru F, Varroud-Vial M, Charpentier G (2003) Sulfonylureas and cardiovascular effects: from experimental data to clinical use. Available data in humans and clinical applications. Diabetes Metab 29:207–222PubMedCrossRef
113.
go back to reference Sulistio M, Carothers C, Mangat M, Lujan M, Oliveros R, Chilton R (2009) GLP-1 agonist-based therapies: an emerging new class of antidiabetic drug with potential cardioprotective effects. Curr Atheroscler Rep 11:93–99PubMedCrossRef Sulistio M, Carothers C, Mangat M, Lujan M, Oliveros R, Chilton R (2009) GLP-1 agonist-based therapies: an emerging new class of antidiabetic drug with potential cardioprotective effects. Curr Atheroscler Rep 11:93–99PubMedCrossRef
114.
go back to reference Hanefeld M, Schaper F (2008) Acarbose: oral anti-diabetes drug with additional cardiovascular benefits. Expert Rev Cardiovasc Ther 6:153–163PubMedCrossRef Hanefeld M, Schaper F (2008) Acarbose: oral anti-diabetes drug with additional cardiovascular benefits. Expert Rev Cardiovasc Ther 6:153–163PubMedCrossRef
115.
go back to reference Gaziano JM, Cincotta AH, O’Connor CM, Ezrokhi M, Rutty D, Ma ZJ et al (2010) Randomized clinical trial of quick-release bromocriptine among patients with type 2 diabetes on overall safety and cardiovascular outcomes. Diabetes Care 33:1503–1508PubMedCrossRef Gaziano JM, Cincotta AH, O’Connor CM, Ezrokhi M, Rutty D, Ma ZJ et al (2010) Randomized clinical trial of quick-release bromocriptine among patients with type 2 diabetes on overall safety and cardiovascular outcomes. Diabetes Care 33:1503–1508PubMedCrossRef
116.
go back to reference Masoudi FA, Inzucchi SE (2007) Diabetes mellitus and heart failure: epidemiology, mechanisms, and pharmacotherapy. Am J Cardiol 99:113B–132BPubMedCrossRef Masoudi FA, Inzucchi SE (2007) Diabetes mellitus and heart failure: epidemiology, mechanisms, and pharmacotherapy. Am J Cardiol 99:113B–132BPubMedCrossRef
117.
go back to reference Lago RM, Singh PP, Nesto RW (2007) Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials. Lancet 370:1129–1136PubMedCrossRef Lago RM, Singh PP, Nesto RW (2007) Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials. Lancet 370:1129–1136PubMedCrossRef
118.
go back to reference Chaggar PS, Shaw SM, Williams SG (2009) Review article: thiazolidinediones and heart failure. Diab Vasc Dis Res 6:146–152PubMedCrossRef Chaggar PS, Shaw SM, Williams SG (2009) Review article: thiazolidinediones and heart failure. Diab Vasc Dis Res 6:146–152PubMedCrossRef
119.
go back to reference Tahrani AA, Varughese GI, Scarpello JH, Hanna FW (2007) Metformin, heart failure, and lactic acidosis: is metformin absolutely contraindicated? BMJ 335:508–512PubMedCrossRef Tahrani AA, Varughese GI, Scarpello JH, Hanna FW (2007) Metformin, heart failure, and lactic acidosis: is metformin absolutely contraindicated? BMJ 335:508–512PubMedCrossRef
120.
go back to reference Inzucchi SE, McGuire DK (2008) New drugs for the treatment of diabetes: part II: incretin-based therapy and beyond. Circulation 117:574–584PubMedCrossRef Inzucchi SE, McGuire DK (2008) New drugs for the treatment of diabetes: part II: incretin-based therapy and beyond. Circulation 117:574–584PubMedCrossRef
121.
go back to reference Huang ES, Liu JY, Moffet HH, John PM, Karter AJ (2011) Glycemic control, complications, and death in older diabetic patients: the diabetes and aging study. Diabetes Care 34:1329–1336PubMedCrossRef Huang ES, Liu JY, Moffet HH, John PM, Karter AJ (2011) Glycemic control, complications, and death in older diabetic patients: the diabetes and aging study. Diabetes Care 34:1329–1336PubMedCrossRef
122.
go back to reference Koro CE, Lee BH, Bowlin SJ (2009) Antidiabetic medication use and prevalence of chronic kidney disease among patients with type 2 diabetes mellitus in the United States. Clin Ther 31:2608–2617PubMedCrossRef Koro CE, Lee BH, Bowlin SJ (2009) Antidiabetic medication use and prevalence of chronic kidney disease among patients with type 2 diabetes mellitus in the United States. Clin Ther 31:2608–2617PubMedCrossRef
123.
go back to reference Holstein A, Stumvoll M (2005) Contraindications can damage your health–is metformin a case in point? Diabetologia 48:2454–2459PubMedCrossRef Holstein A, Stumvoll M (2005) Contraindications can damage your health–is metformin a case in point? Diabetologia 48:2454–2459PubMedCrossRef
124.
go back to reference Lipska KJ, Bailey CJ, Inzucchi SE (2011) Use of metformin in the setting of mild-to-moderate renal insufficiency. Diabetes Care 34:1431–1437PubMedCrossRef Lipska KJ, Bailey CJ, Inzucchi SE (2011) Use of metformin in the setting of mild-to-moderate renal insufficiency. Diabetes Care 34:1431–1437PubMedCrossRef
125.
go back to reference Nye HJ, Herrington WG (2011) Metformin: the safest hypoglycaemic agent in chronic kidney disease? Nephron Clin Pract 118:c380–c383PubMedCrossRef Nye HJ, Herrington WG (2011) Metformin: the safest hypoglycaemic agent in chronic kidney disease? Nephron Clin Pract 118:c380–c383PubMedCrossRef
126.
go back to reference Ong JP, Younossi ZM (2007) Epidemiology and natural history of NAFLD and NASH. Clin Liver Dis 11:1–16, viiPubMedCrossRef Ong JP, Younossi ZM (2007) Epidemiology and natural history of NAFLD and NASH. Clin Liver Dis 11:1–16, viiPubMedCrossRef
127.
go back to reference Musso G, Gambino R, Cassader M, Pagano G (2011) Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity. Ann Med 43:617–649PubMedCrossRef Musso G, Gambino R, Cassader M, Pagano G (2011) Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity. Ann Med 43:617–649PubMedCrossRef
128.
go back to reference Tushuizen ME, Bunck MC, Pouwels PJ, van Waesberghe JH, Diamant M, Heine RJ (2006) Incretin mimetics as a novel therapeutic option for hepatic steatosis. Liver Int 26:1015–1017PubMedCrossRef Tushuizen ME, Bunck MC, Pouwels PJ, van Waesberghe JH, Diamant M, Heine RJ (2006) Incretin mimetics as a novel therapeutic option for hepatic steatosis. Liver Int 26:1015–1017PubMedCrossRef
129.
go back to reference Gerstein HC, Miller ME, Genuth S et al (2011) Long-term effects of intensive glucose lowering on cardiovascular outcomes. N Engl J Med 364:818–828PubMedCrossRef Gerstein HC, Miller ME, Genuth S et al (2011) Long-term effects of intensive glucose lowering on cardiovascular outcomes. N Engl J Med 364:818–828PubMedCrossRef
130.
go back to reference Bonds DE, Miller ME, Bergenstal RM et al (2010) The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study. BMJ 340:b4909PubMedCrossRef Bonds DE, Miller ME, Bergenstal RM et al (2010) The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study. BMJ 340:b4909PubMedCrossRef
131.
go back to reference Riddle MC (2010) Counterpoint: intensive glucose control and mortality in ACCORD–still looking for clues. Diabetes Care 33:2722–2724PubMedCrossRef Riddle MC (2010) Counterpoint: intensive glucose control and mortality in ACCORD–still looking for clues. Diabetes Care 33:2722–2724PubMedCrossRef
132.
go back to reference Berlie HD, Garwood CL (2010) Diabetes medications related to an increased risk of falls and fall-related morbidity in the elderly. Ann Pharmacother 44:712–717PubMedCrossRef Berlie HD, Garwood CL (2010) Diabetes medications related to an increased risk of falls and fall-related morbidity in the elderly. Ann Pharmacother 44:712–717PubMedCrossRef
133.
go back to reference Rodbard D (2010) The combinatorics of medications precludes evidence-based algorithms for therapy. Diabetologia 53:2456–2457PubMedCrossRef Rodbard D (2010) The combinatorics of medications precludes evidence-based algorithms for therapy. Diabetologia 53:2456–2457PubMedCrossRef
134.
go back to reference Chiasson JL, Josse RG, Gomis R et al (2003) Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA 290:486–494PubMedCrossRef Chiasson JL, Josse RG, Gomis R et al (2003) Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA 290:486–494PubMedCrossRef
Metadata
Title
Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
Authors
S. E. Inzucchi
R. M. Bergenstal
J. B. Buse
M. Diamant
E. Ferrannini
M. Nauck
A. L. Peters
A. Tsapas
R. Wender
D. R. Matthews
Publication date
01-06-2012
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 6/2012
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-012-2534-0

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