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Diabetologia
Published in: Diabetologia 5/2008

Open Access 01-05-2008 | Letter

Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: do adipocytes consume sufficient amounts of oxygen to oxidise fatty acids?

Authors: J. A. Maassen, J. A. Romijn, R. J. Heine

Published in: Diabetologia | Issue 5/2008

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Excerpt

The phenotype of patients with various forms of congenital lipodystrophy has indicated that proper storage of triacylglycerol in peripheral adipocytes is essential to prevent formation of ectopic fat deposits and development of type 2 diabetes [1]. A similar situation with induced peripheral lipodystrophy and elevated risk for type 2 diabetes is seen in patients undergoing highly active anti-retroviral therapy (HAART). In these patients, there is a 30–50% decline in mitochondrial copy number as a result of HAART [2]. …
Literature
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Capeau J, Magré J, Lascols O et al (2005) Diseases of adipose tissue: genetic and acquired lipodystrophies. Biochem Soc Trans 33:1073–1077PubMedCrossRef
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Brinkman K, Smeitink JA, Romijn JA, Reiss P (1999) Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy. Lancet 354:1112–1115PubMedCrossRef
3.
Maassen JA, Romijn JA, Heine RJ (2007) Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: a new concept in the pathogenesis of obesity-associated type 2 diabetes mellitus. Diabetologia 50:2036–2041PubMedCrossRef
4.
Kaaman M, Sparks LM, van Harmelen V et al (2007) Strong association between mitochondrial DNA copy number and lipogenesis in human white adipose tissue. Diabetologia 50:2526–2533PubMedCrossRef
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Frayn KN, Langin D, Karpe F (2008) Fatty acid-induced mitochondrial uncoupling in adipocytes is not a promising target for treatment of insulin resistance unless adipocyte oxidative capacity is increased. Diabetologia (in press). DOI 10.​1007/​s00125-007-0901-z
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Coppack SW, Fisher RM, Gibbons GF et al (1990) Postprandial substrate deposition in human forearm and adipose tissues in vivo. Clin Sci (Lond) 79:339–348
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Baril JG, Junod P, Leblanc R et al (2005) HIV-associated lipodystrophy syndrome: a review of clinical aspects. Can J Infect Dis Med Microbiol 16:233–243PubMed
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Hallgren P, Sjöström L, Hedlund H, Lundell L, Olbe L (1989) Influence of age, fat cell weight, and obesity on O2 consumption of human adipose tissue. Am J Physiol 256:E467–E474PubMed
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Sjöström L, Björntorp P, Vrána J (1971) Microscopic fat cell size measurements on frozen-cut adipose tissue in comparison with automatic determinations of osmium-fixed fat cells. J Lipid Res 12:521–530PubMed
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Nedergaard J, Bengtsson T, Cannon B (2007) Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol 293:E444–E452
Metadata
Title
Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: do adipocytes consume sufficient amounts of oxygen to oxidise fatty acids?
Authors
J. A. Maassen
J. A. Romijn
R. J. Heine
Publication date
01-05-2008
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 5/2008
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-008-0963-6

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