Skip to main content
Top
Published in: Diabetologia 7/2005

01-07-2005 | Commentary

Insulin resistance and the metabolic syndrome

Author: L. Landsberg

Published in: Diabetologia | Issue 7/2005

Login to get access

Excerpt

In this issue of Diabetologia, Grassi and colleagues report increased muscle sympathetic nerve activity in patients with a collection of cardiovascular risk factors known as the metabolic syndrome [1]. They present evidence that the increase in sympathetic activity in this syndrome is related to insulin resistance and is associated with decreased baroreflex sensitivity. …
Literature
1.
go back to reference Grassi G, Dell’Oro R, Quarti-Trevano F et al (2005) Neuroadrenergic and reflex abnormalities in patients with metabolic syndrome. Diabetologia DOI 10.1007/s00125-005-1798-z Grassi G, Dell’Oro R, Quarti-Trevano F et al (2005) Neuroadrenergic and reflex abnormalities in patients with metabolic syndrome. Diabetologia DOI 10.1007/s00125-005-1798-z
2.
go back to reference Hansen BC (1999) The metabolic syndrome X. Ann NY Acad Sci 892:1–24PubMed Hansen BC (1999) The metabolic syndrome X. Ann NY Acad Sci 892:1–24PubMed
3.
go back to reference Landsberg L (2004) The metabolic syndrome: diabetes, obesity and hypertension. In: Birkenhäger WH, Robertson JJS, Zanchetti A (eds) Handbook of hypertension, vol. 22. Elsevier, Amsterdam, pp 245–261 Landsberg L (2004) The metabolic syndrome: diabetes, obesity and hypertension. In: Birkenhäger WH, Robertson JJS, Zanchetti A (eds) Handbook of hypertension, vol. 22. Elsevier, Amsterdam, pp 245–261
4.
go back to reference Rowe JW, Young JB, Minaker KL, Stevens AL, Pallotta J, Landsberg L (1981) Effect of insulin and glucose infusions on sympathetic nervous system activity in normal man. Diabetes 30:219–225PubMed Rowe JW, Young JB, Minaker KL, Stevens AL, Pallotta J, Landsberg L (1981) Effect of insulin and glucose infusions on sympathetic nervous system activity in normal man. Diabetes 30:219–225PubMed
5.
go back to reference Hausberg M, Mark AL, Hoffman, RP, Sinkey CA, Anderson EA (1995) Dissociation of sympathoexcitatory and vasodilator actions of modestly elevated plasma insulin levels. J Hypertens 13:1015–1021PubMed Hausberg M, Mark AL, Hoffman, RP, Sinkey CA, Anderson EA (1995) Dissociation of sympathoexcitatory and vasodilator actions of modestly elevated plasma insulin levels. J Hypertens 13:1015–1021PubMed
6.
go back to reference Troisi RJ, Weiss ST, Parker DR, Sparrow D, Young JB, Landsberg L (1991) Relation of obesity and diet to sympathetic nervous system activity. Hypertension 17:669–677PubMed Troisi RJ, Weiss ST, Parker DR, Sparrow D, Young JB, Landsberg L (1991) Relation of obesity and diet to sympathetic nervous system activity. Hypertension 17:669–677PubMed
7.
go back to reference Grassi G, Dell’Oro R, Facchini A, Trevano FQ, Bolla GB, Mancia G (2004) Effect of central and peripheral body fat distribution on sympathetic and baroreflex function in obese normotensives. J Hypertens 22:2363–2369CrossRefPubMed Grassi G, Dell’Oro R, Facchini A, Trevano FQ, Bolla GB, Mancia G (2004) Effect of central and peripheral body fat distribution on sympathetic and baroreflex function in obese normotensives. J Hypertens 22:2363–2369CrossRefPubMed
8.
go back to reference Haynes WG, Morgan DA, Walsh SA, Mark AL, Sivitz WI (1997) Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest 100:270–278PubMed Haynes WG, Morgan DA, Walsh SA, Mark AL, Sivitz WI (1997) Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest 100:270–278PubMed
9.
go back to reference Kazumi T, Kawaguchi A, Katoh J, Iwahashi M, Yoshino G (1999) Fasting insulin and leptin serum levels are associated with systolic blood pressure independent of percentage body fat and body mass index. J Hypertens 17:1451–1455CrossRefPubMed Kazumi T, Kawaguchi A, Katoh J, Iwahashi M, Yoshino G (1999) Fasting insulin and leptin serum levels are associated with systolic blood pressure independent of percentage body fat and body mass index. J Hypertens 17:1451–1455CrossRefPubMed
10.
go back to reference Giacchetta G, Faloia E, Sardu C et al (2000) Gene expression of angiotensinogen in adipose tissue of obese patients. Int J Obes 24 [Suppl. 2]:S142–S143 Giacchetta G, Faloia E, Sardu C et al (2000) Gene expression of angiotensinogen in adipose tissue of obese patients. Int J Obes 24 [Suppl. 2]:S142–S143
11.
go back to reference Ward KD, Sparrow D, Landsberg L, Young JB, Vokonas PS, Weiss ST (1994) The relationship of epinephrine excretion to serum lipid levels: the normative aging study. Metabolism 43:509–513CrossRefPubMed Ward KD, Sparrow D, Landsberg L, Young JB, Vokonas PS, Weiss ST (1994) The relationship of epinephrine excretion to serum lipid levels: the normative aging study. Metabolism 43:509–513CrossRefPubMed
12.
go back to reference Young JB, Landsberg L (1977) Suppression of sympathetic nervous system during fasting. Science 196:1473–1475PubMed Young JB, Landsberg L (1977) Suppression of sympathetic nervous system during fasting. Science 196:1473–1475PubMed
13.
go back to reference Young JB, Landsberg L (1977) Stimulation of the sympathetic nervous system during sucrose feeding. Nature 269:615–617 Young JB, Landsberg L (1977) Stimulation of the sympathetic nervous system during sucrose feeding. Nature 269:615–617
14.
go back to reference Landsberg L (2001) Insulin-mediated sympathetic stimulation: role in the pathogenesis of obesity-related hypertension (or, how insulin affects blood pressure, and why). J Hypertens 19:523–528CrossRefPubMed Landsberg L (2001) Insulin-mediated sympathetic stimulation: role in the pathogenesis of obesity-related hypertension (or, how insulin affects blood pressure, and why). J Hypertens 19:523–528CrossRefPubMed
15.
go back to reference Landsberg L, Young JB (1985) Insulin-mediated glucose metabolism in the relationship between dietary intake and sympathetic nervous system activity. Int J Obes 9:63–68 Landsberg L, Young JB (1985) Insulin-mediated glucose metabolism in the relationship between dietary intake and sympathetic nervous system activity. Int J Obes 9:63–68
16.
go back to reference Landsberg L (1986) Diet, obesity and hypertension: a hypothesis involving insulin, the sympathetic nervous system, and adaptive thermogenesis. Q J Med 236:1081–1090 Landsberg L (1986) Diet, obesity and hypertension: a hypothesis involving insulin, the sympathetic nervous system, and adaptive thermogenesis. Q J Med 236:1081–1090
17.
go back to reference Reaven GM (1999) Insulin resistance: a chicken that has come to roost. Ann NY Acad Sci 892:45–57PubMed Reaven GM (1999) Insulin resistance: a chicken that has come to roost. Ann NY Acad Sci 892:45–57PubMed
Metadata
Title
Insulin resistance and the metabolic syndrome
Author
L. Landsberg
Publication date
01-07-2005
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 7/2005
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-005-1818-z

Other articles of this Issue 7/2005

Diabetologia 7/2005 Go to the issue