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European Journal of Trauma and Emergency Surgery

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07-05-2022 | Central Nervous System Trauma | Original Article

The diagnostic and prognostic value of glial fibrillary acidic protein in traumatic brain injury: a systematic review and meta-analysis

Authors: Yunlong Pei, Xiaojia Tang, Enpeng Zhang, Kongye Lu, Boming Xia, Jun Zhang, Yujia Huang, HengZhu Zhang, Lun Dong

Published in: European Journal of Trauma and Emergency Surgery | Issue 3/2023

Abstract

Objectives

Over the years, blood biomarkers have been extensively applied for diagnostic and prognostic assessment of traumatic brain injury (TBI). Herein, we conducted a meta-analysis to evaluate the diagnostic and prognostic value of glial fibrillary acidic protein (GFAP) for TBI patients.

Methods

The online databases, including PubMed, Embase, Cochrane Library, CNKI, and WFSD, were systematically retrieved from inception until May 2021. The RevMan 5.3 software and Stata 15 were used to conduct data analysis.

Results

A total of 22 eligible studies comprising 3709 patients were included in this meta-analysis. The pooled results indicated that serum GFAP had a diagnostic value in detecting traumatic intracranial lesions (AUC 0.81; 95% CI 0.77–0.84; p < 0.00001). The pooled sensitivity and specificity were 0.93 (95% CI 0.81–0.98), and 0.66 (95% 0.53–0.77; p < 0.00001), respectively. For assessment of unfavorable outcome, the pooled sensitivity, specificity and AUC value were 0.66 (95% CI 0.54–0.76; p < 0.00001), 0.82(95% CI 0.72–0.90; p < 0.00001), and 0.82 (95% CI 0.76–0.88; p < 0.00001), respectively. Besides, GFAP exhibited a significant value in predicting mortality (AUC 0.81; 95% CI 0.77–0.84; p < 0.00001), with high sensitivity and specificity (0.86, 95% CI 0.79–0.92, p < 0.00001, and 0.66, 95% CI 0.52–0.77, p < 0.00001). The subgroup analysis indicated that the type of TBI and cut-off value were potential sources of heterogeneity, which influenced the pooled AUC values for mortality prediction.

Conclusions

Our meta-analysis indicated that GFAP had diagnostic and prognostic value for TBI patients, especially during the early TBI.

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Title: The diagnostic and prognostic value of glial fibrillary acidic protein in traumatic brain injury: a systematic review and meta-analysis
Authors: Yunlong Pei
Xiaojia Tang
Enpeng Zhang
Kongye Lu
Boming Xia
Jun Zhang
Yujia Huang
HengZhu Zhang
Lun Dong
Publication date: 07-05-2022
Publisher: Springer Berlin Heidelberg
Keyword: Central Nervous System Trauma
Published in: European Journal of Trauma and Emergency Surgery / Issue 3/2023
Print ISSN: 1863-9933
Electronic ISSN: 1863-9941
DOI: https://doi.org/10.1007/s00068-022-01979-y

At a glance: The STEP trials

Springer Medicine

The diagnostic and prognostic value of glial fibrillary acidic protein in traumatic brain injury: a systematic review and meta-analysis

Abstract

Objectives

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

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