Skip to main content
Top
Published in: European Journal of Trauma and Emergency Surgery 3/2023

Open Access 28-01-2023 | Appendicitis | Original Article

Risk factors for postoperative morbidity, prolonged length of stay and hospital readmission after appendectomy for acute appendicitis

Authors: Bruno Leonardo Bancke Laverde, Matthias Maak, Melanie Langheinrich, Stephan Kersting, Axel Denz, Christian Krautz, Georg Ferdinand Weber, Robert Grützmann, Maximilian Brunner

Published in: European Journal of Trauma and Emergency Surgery | Issue 3/2023

Login to get access

Abstract

Purpose

The aim of the present study was to identify risk factors associated with postoperative morbidity and major morbidity, with a prolonged length of hospital stay and with the need of readmission in patients undergoing appendectomy due to acute appendicitis.

Methods

We performed a retrospective analysis of 1638 adult patients who underwent emergency appendectomy for preoperatively suspected acute appendicitis from 2010 to 2020 at the University Hospital Erlangen. Data including patient demographics, pre-, intra-, and postoperative findings were collected and compared between different outcome groups (morbidity, major morbidity, prolonged length of postoperative hospital stay (LOS) and readmission) from those patients with verified acute appendicitis (n = 1570).

Results

Rate of negative appendectomies was 4%. In patients with verified acute appendicitis, morbidity, major morbidity and readmission occurred in 6%, 3% and 2%, respectively. Mean LOS was 3.9 days. Independent risk factors for morbidity were higher age, higher preoperative WBC-count and CRP, lower preoperative hemoglobin, longer time to surgery and longer duration of surgery. As independent risk factors for major morbidity could be identified higher age, higher preoperative CRP, lower preoperative hemoglobin and longer time to surgery. Eight parameters were independent risk factors for a prolonged LOS: higher age, higher preoperative WBC-count and CRP, lower preoperative hemoglobin, need for conversion, longer surgery duration, presence of intraoperative complicated appendicitis and of postoperative morbidity. Presence of malignancy and higher preoperative WBC-count were independent risk factors for readmission.

Conclusion

Among patients undergoing appendectomy for acute appendicitis, there are relevant risk factors predicting postoperative complications, prolonged hospital stays and readmission. Patients with the presence of the identified risk factors should receive special attention in the postoperative course and may benefit from a more individualized therapy.
Appendix
Available only for authorised users
Literature
1.
go back to reference Ferris M, Quan S, Kaplan BS, et al. The global incidence of appendicitis. Ann Surg. 2017;266(2):237–41.PubMed Ferris M, Quan S, Kaplan BS, et al. The global incidence of appendicitis. Ann Surg. 2017;266(2):237–41.PubMed
2.
go back to reference Stöß C, Nitsche U, Neumann PA, et al. Acute appendicitis: trends in surgical treatment—a population-based study of over 800 000 patients. Deutsches Aerzteblatt International. 2021;118(14):244–9. Stöß C, Nitsche U, Neumann PA, et al. Acute appendicitis: trends in surgical treatment—a population-based study of over 800 000 patients. Deutsches Aerzteblatt International. 2021;118(14):244–9.
3.
go back to reference Varadhan KK, Neal KR, Lobo DN. Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials. BMJ. 2012;344: e2156.PubMedPubMedCentral Varadhan KK, Neal KR, Lobo DN. Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials. BMJ. 2012;344: e2156.PubMedPubMedCentral
4.
go back to reference Hansson J, Körner U, Khorram-Manesh A, et al. Randomized clinical trial of antibiotic therapy versus appendicectomy as primary treatment of acute appendicitis in unselected patients. Br J Surg. 2009;96(5):473–81.PubMed Hansson J, Körner U, Khorram-Manesh A, et al. Randomized clinical trial of antibiotic therapy versus appendicectomy as primary treatment of acute appendicitis in unselected patients. Br J Surg. 2009;96(5):473–81.PubMed
5.
go back to reference McCutcheon BA, Chang DC, Marcus LP, et al. Long-term outcomes of patients with nonsurgically managed uncomplicated appendicitis. J Am Coll Surg. 2014;218(5):905–13.PubMedPubMedCentral McCutcheon BA, Chang DC, Marcus LP, et al. Long-term outcomes of patients with nonsurgically managed uncomplicated appendicitis. J Am Coll Surg. 2014;218(5):905–13.PubMedPubMedCentral
6.
go back to reference Vons C, Barry C, Maitre S, Pautrat K, et al. Amoxicillin plus clavulanic acid versus appendicectomy for treatment of acute uncomplicated appendicitis: an open-label, non-inferiority, randomised controlled trial. Lancet. 2011;377(9777):1573–9.PubMed Vons C, Barry C, Maitre S, Pautrat K, et al. Amoxicillin plus clavulanic acid versus appendicectomy for treatment of acute uncomplicated appendicitis: an open-label, non-inferiority, randomised controlled trial. Lancet. 2011;377(9777):1573–9.PubMed
7.
go back to reference Salminen P, Paajanen H, Rautio T, et al. Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis: the APPAC randomized clinical trial. JAMA. 2015;313(23):2340–8.PubMed Salminen P, Paajanen H, Rautio T, et al. Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis: the APPAC randomized clinical trial. JAMA. 2015;313(23):2340–8.PubMed
8.
go back to reference Birnbaum BA, Wilson SR. Appendicitis at the millennium. Radiology. 2000;215:337–48.PubMed Birnbaum BA, Wilson SR. Appendicitis at the millennium. Radiology. 2000;215:337–48.PubMed
9.
go back to reference Wilms IM, de Hoog DE, de Visser DC, Janzing HM. Appendectomy versus antibiotic treatment for acute appendicitis. Cochrane Database Syst Rev. 2011;11: CD008359. Wilms IM, de Hoog DE, de Visser DC, Janzing HM. Appendectomy versus antibiotic treatment for acute appendicitis. Cochrane Database Syst Rev. 2011;11: CD008359.
10.
go back to reference Angeramo CA, Dreifuss NH, Olivero AA, et al. Risk factors for readmission after short-hospital-stay laparoscopic appendectomy. World J Surg. 2020;44(12):4006–11.PubMed Angeramo CA, Dreifuss NH, Olivero AA, et al. Risk factors for readmission after short-hospital-stay laparoscopic appendectomy. World J Surg. 2020;44(12):4006–11.PubMed
11.
go back to reference Andert A, Alizai HP, Klink CD, et al. Risk factors for morbidity after appendectomy. Langenbeck’s Arch Surg. 2017;402(6):987–93. Andert A, Alizai HP, Klink CD, et al. Risk factors for morbidity after appendectomy. Langenbeck’s Arch Surg. 2017;402(6):987–93.
12.
go back to reference Kostov K. Risk factors and outcomes for septic complications after laparoscopic appendectomy. J IMAB Ann Proc (Sci Papers). 2021;27(4):4084–6. Kostov K. Risk factors and outcomes for septic complications after laparoscopic appendectomy. J IMAB Ann Proc (Sci Papers). 2021;27(4):4084–6.
14.
go back to reference Walędziak M, Lasek A, Wysocki M, et al. Risk factors for serious Morbidity, prolonged length of stay and hospital readmission after laparoscopic appendectomy—results from Pol-LA (Polish Laparoscopic Appendectomy) multicenter large cohort study. Sci Rep. 2019;9(1):1–9. Walędziak M, Lasek A, Wysocki M, et al. Risk factors for serious Morbidity, prolonged length of stay and hospital readmission after laparoscopic appendectomy—results from Pol-LA (Polish Laparoscopic Appendectomy) multicenter large cohort study. Sci Rep. 2019;9(1):1–9.
15.
go back to reference Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205–13.PubMedPubMedCentral Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205–13.PubMedPubMedCentral
16.
go back to reference Seetahal SA, Bolorunduro OB, Sookdeo TC, Oyetunji TA, Greene WR, Frederick W, Cornwell EE 3rd, Chang DC, Siram SM. Negative appendectomy: a 10-year review of a nationally representative sample. Am J Surg. 2011;201(4):433–7.PubMed Seetahal SA, Bolorunduro OB, Sookdeo TC, Oyetunji TA, Greene WR, Frederick W, Cornwell EE 3rd, Chang DC, Siram SM. Negative appendectomy: a 10-year review of a nationally representative sample. Am J Surg. 2011;201(4):433–7.PubMed
17.
go back to reference Tamini N, Santurro L, Chiappetta MF, Gattuso I, Barbieri C, Fattori L, Gianotti L. Morbidity after negative appendectomy: a single-centre experience on 627 cases. Eur J Trauma Emerg Surg. 2020;46(4):859–64.PubMed Tamini N, Santurro L, Chiappetta MF, Gattuso I, Barbieri C, Fattori L, Gianotti L. Morbidity after negative appendectomy: a single-centre experience on 627 cases. Eur J Trauma Emerg Surg. 2020;46(4):859–64.PubMed
18.
go back to reference Lee M, Paavana T, Mazari F, Wilson TR. The morbidity of negative appendicectomy. Ann R Coll Surg Engl. 2014;96(7):517–20.PubMedPubMedCentral Lee M, Paavana T, Mazari F, Wilson TR. The morbidity of negative appendicectomy. Ann R Coll Surg Engl. 2014;96(7):517–20.PubMedPubMedCentral
19.
go back to reference Patel SV, Nanji S, Brogly SB, et al. High complication rate among patients undergoing appendectomy in Ontario: a population-based retrospective cohort study. Can J Surg. 2018;61(6):412–7.PubMedPubMedCentral Patel SV, Nanji S, Brogly SB, et al. High complication rate among patients undergoing appendectomy in Ontario: a population-based retrospective cohort study. Can J Surg. 2018;61(6):412–7.PubMedPubMedCentral
20.
go back to reference Pereira BM, Mendes CA, Ruano RM, et al. Acute appendicitis may no longer be a predominant disease of the young population. Anaesthesiol Intensive Therapy. 2019;51(4):283–8. Pereira BM, Mendes CA, Ruano RM, et al. Acute appendicitis may no longer be a predominant disease of the young population. Anaesthesiol Intensive Therapy. 2019;51(4):283–8.
21.
go back to reference Kim JY, Kim JW, Park JH, et al. Early versus late surgical management for complicated appendicitis in adults: a multicenter propensity score matching study. Ann Surg Treat Res. 2019;97(2):103–11.PubMedPubMedCentral Kim JY, Kim JW, Park JH, et al. Early versus late surgical management for complicated appendicitis in adults: a multicenter propensity score matching study. Ann Surg Treat Res. 2019;97(2):103–11.PubMedPubMedCentral
22.
go back to reference de Wijkerslooth EML, de Jonge J, van den Boom AL, et al. Postoperative outcomes of patients with nonperforated gangrenous appendicitis: a national multicenter prospective cohort analysis. Dis Colon Rectum. 2019;62(11):1363–70.PubMed de Wijkerslooth EML, de Jonge J, van den Boom AL, et al. Postoperative outcomes of patients with nonperforated gangrenous appendicitis: a national multicenter prospective cohort analysis. Dis Colon Rectum. 2019;62(11):1363–70.PubMed
23.
go back to reference Sood A, Meyer CP, Abdollah F, et al. Minimally invasive surgery and its impact on 30-day postoperative complications, unplanned readmissions and mortality. Br J Surg. 2017;104(10):1372–81.PubMed Sood A, Meyer CP, Abdollah F, et al. Minimally invasive surgery and its impact on 30-day postoperative complications, unplanned readmissions and mortality. Br J Surg. 2017;104(10):1372–81.PubMed
24.
go back to reference Kotaluoto S, Ukkonen M, Pauniaho SL, et al. Mortality related to appendectomy; a population based analysis over two decades in Finland. World J Surg. 2017;41(1):64–9.PubMed Kotaluoto S, Ukkonen M, Pauniaho SL, et al. Mortality related to appendectomy; a population based analysis over two decades in Finland. World J Surg. 2017;41(1):64–9.PubMed
25.
go back to reference Blomqvist PG, Andersson RE, Granath F, et al. Mortality after appendectomy in Sweden, 1987–1996. Ann Surg. 2001;233(4):455–60.PubMedPubMedCentral Blomqvist PG, Andersson RE, Granath F, et al. Mortality after appendectomy in Sweden, 1987–1996. Ann Surg. 2001;233(4):455–60.PubMedPubMedCentral
26.
go back to reference Abou-Nukta F, Bakhos C, Arroyo K, et al. Effects of delaying appendectomy for acute appendicitis for 12 to 24 hours. Arch Surg. 2006;141:504–6 (discussion 6–7).PubMed Abou-Nukta F, Bakhos C, Arroyo K, et al. Effects of delaying appendectomy for acute appendicitis for 12 to 24 hours. Arch Surg. 2006;141:504–6 (discussion 6–7).PubMed
27.
go back to reference United Kingdom National Surgical Research Collaborative, Bhangu A. Safety of short, in-hospital delays before surgery for acute appendicitis: multicentre cohort study, systematic review, and meta-analysis. Ann Surg. 2014;259:894–903. United Kingdom National Surgical Research Collaborative, Bhangu A. Safety of short, in-hospital delays before surgery for acute appendicitis: multicentre cohort study, systematic review, and meta-analysis. Ann Surg. 2014;259:894–903.
28.
go back to reference Kim HK, Kim YS, Lee SH, et al. Impact of a delayed laparoscopic appendectomy on the risk of complications in acute appendicitis: a retrospective study of 4,065 patients. Dig Surg. 2017;34:25–9.PubMed Kim HK, Kim YS, Lee SH, et al. Impact of a delayed laparoscopic appendectomy on the risk of complications in acute appendicitis: a retrospective study of 4,065 patients. Dig Surg. 2017;34:25–9.PubMed
29.
go back to reference Fair BA, Kubasiak JC, Janssen I, et al. The impact of operative timing on outcomes of appendicitis: a National Surgical Quality Improvement Project analysis. Am J Surg. 2015;209:498–502.PubMed Fair BA, Kubasiak JC, Janssen I, et al. The impact of operative timing on outcomes of appendicitis: a National Surgical Quality Improvement Project analysis. Am J Surg. 2015;209:498–502.PubMed
30.
go back to reference March B, Gillies D, Gani J. Appendicectomies performed >48 hours after admission to a dedicated acute general surgical unit. Ann R Coll Surg Engl. 2014;96:614–7.PubMedPubMedCentral March B, Gillies D, Gani J. Appendicectomies performed >48 hours after admission to a dedicated acute general surgical unit. Ann R Coll Surg Engl. 2014;96:614–7.PubMedPubMedCentral
31.
go back to reference Teixeira PG, Sivrikoz E, Inaba K, et al. Appendectomy timing: waiting until the next morning increases the risk of surgical site infections. Ann Surg. 2012;256:538–43.PubMed Teixeira PG, Sivrikoz E, Inaba K, et al. Appendectomy timing: waiting until the next morning increases the risk of surgical site infections. Ann Surg. 2012;256:538–43.PubMed
32.
go back to reference Giraudo G, Baracchi F, Pellegrino L, et al. Prompt or delayed appendectomy? Influence of timing of surgery for acute appendicitis. Surg Today. 2013;43:392–6.PubMed Giraudo G, Baracchi F, Pellegrino L, et al. Prompt or delayed appendectomy? Influence of timing of surgery for acute appendicitis. Surg Today. 2013;43:392–6.PubMed
33.
go back to reference Andert A, Alizai HP, Klink CD, et al. Risk factors for morbidity after appendectomy. Langenbecks Arch Surg. 2017;402(6):987–93.PubMed Andert A, Alizai HP, Klink CD, et al. Risk factors for morbidity after appendectomy. Langenbecks Arch Surg. 2017;402(6):987–93.PubMed
34.
go back to reference van Dijk ST, van Dijk AH, Dijkgraaf MG, Boermeester MA. Meta-analysis of in-hospital delay before surgery as a risk factor for complications in patients with acute appendicitis. Br J Surg. 2018;105(8):933–45.PubMedPubMedCentral van Dijk ST, van Dijk AH, Dijkgraaf MG, Boermeester MA. Meta-analysis of in-hospital delay before surgery as a risk factor for complications in patients with acute appendicitis. Br J Surg. 2018;105(8):933–45.PubMedPubMedCentral
35.
go back to reference Li J, Xu R, Hu DM, Zhang Y, Gong TP, Wu XL. Effect of delay to operation on outcomes in patients with acute appendicitis: a systematic review and meta-analysis. J Gastrointest Surg. 2019;23(1):210–23.PubMed Li J, Xu R, Hu DM, Zhang Y, Gong TP, Wu XL. Effect of delay to operation on outcomes in patients with acute appendicitis: a systematic review and meta-analysis. J Gastrointest Surg. 2019;23(1):210–23.PubMed
36.
go back to reference van den Boom AL, de Wijkerslooth EML, Wijnhoven BPL. Systematic review and meta-analysis of postoperative antibiotics for patients with a complex appendicitis. Dig Surg. 2020;37(2):101–10.PubMed van den Boom AL, de Wijkerslooth EML, Wijnhoven BPL. Systematic review and meta-analysis of postoperative antibiotics for patients with a complex appendicitis. Dig Surg. 2020;37(2):101–10.PubMed
37.
go back to reference Pedziwiatr M, Lasek A, Wysocki M, et al. Complicated appendicitis: risk factors and outcomes of laparoscopic appendectomy—polish laparoscopic appendectomy results from a multicenter, large-cohort study. Ulus Travma ve Acil Cerrahi Derg. 2019;25(2):129–36. Pedziwiatr M, Lasek A, Wysocki M, et al. Complicated appendicitis: risk factors and outcomes of laparoscopic appendectomy—polish laparoscopic appendectomy results from a multicenter, large-cohort study. Ulus Travma ve Acil Cerrahi Derg. 2019;25(2):129–36.
38.
go back to reference Ward NT, Ramamoorthy SL, Chang DC, et al. Laparoscopic appendectomy is safer than open appendectomy in an elderly population. J Soc Laparoendoscopic Surgeons. 2014;18(3): e2014.00322. Ward NT, Ramamoorthy SL, Chang DC, et al. Laparoscopic appendectomy is safer than open appendectomy in an elderly population. J Soc Laparoendoscopic Surgeons. 2014;18(3): e2014.00322.
39.
go back to reference Moreira LF, Garbin HI, Da-Natividade GR, et al. Predicting factors of postoperative complications in appendectomies. Rev Col Bras Cir. 2018;45(5): e19.PubMed Moreira LF, Garbin HI, Da-Natividade GR, et al. Predicting factors of postoperative complications in appendectomies. Rev Col Bras Cir. 2018;45(5): e19.PubMed
40.
go back to reference Zhang P, Zhang Q, Zhao H, et al. Factors affecting the length of hospital stay after laparoscopic appendectomy: a single center study. PLoS ONE. 2020;15(12 December): e0243575.PubMedPubMedCentral Zhang P, Zhang Q, Zhao H, et al. Factors affecting the length of hospital stay after laparoscopic appendectomy: a single center study. PLoS ONE. 2020;15(12 December): e0243575.PubMedPubMedCentral
41.
go back to reference Demir C, Çelik Y, Gider Ö, et al. The factors affecting length of stay of the patients undergoing appendectomy surgery in a military teaching hospital. Military Med. 2007;172(6):634–9. Demir C, Çelik Y, Gider Ö, et al. The factors affecting length of stay of the patients undergoing appendectomy surgery in a military teaching hospital. Military Med. 2007;172(6):634–9.
42.
go back to reference Bailey K, Choynowski M, Kabir SMU, et al. Meta-analysis of unplanned readmission to hospital post-appendectomy: an opportunity for a new benchmark. ANZ J Surg. 2019;89(11):1386–91.PubMed Bailey K, Choynowski M, Kabir SMU, et al. Meta-analysis of unplanned readmission to hospital post-appendectomy: an opportunity for a new benchmark. ANZ J Surg. 2019;89(11):1386–91.PubMed
43.
go back to reference Brunner M, Lapins P, Langheinrich M, et al. Risk factors for appendiceal neoplasm and malignancy among patients with acute appendicitis. Int J Colorectal Dis. 2020;35(1):157–63.PubMed Brunner M, Lapins P, Langheinrich M, et al. Risk factors for appendiceal neoplasm and malignancy among patients with acute appendicitis. Int J Colorectal Dis. 2020;35(1):157–63.PubMed
Metadata
Title
Risk factors for postoperative morbidity, prolonged length of stay and hospital readmission after appendectomy for acute appendicitis
Authors
Bruno Leonardo Bancke Laverde
Matthias Maak
Melanie Langheinrich
Stephan Kersting
Axel Denz
Christian Krautz
Georg Ferdinand Weber
Robert Grützmann
Maximilian Brunner
Publication date
28-01-2023
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Trauma and Emergency Surgery / Issue 3/2023
Print ISSN: 1863-9933
Electronic ISSN: 1863-9941
DOI
https://doi.org/10.1007/s00068-023-02225-9

Other articles of this Issue 3/2023

European Journal of Trauma and Emergency Surgery 3/2023 Go to the issue