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01-07-2017 | Original Article

Reirradiation for recurrent head and neck cancers using charged particle or photon radiotherapy

Authors: Hideya Yamazaki, MD, Yusuke Demizu, MD, Tomoaki Okimoto, MD, Mikio Ogita, MD, Kengo Himei, MD, Satoaki Nakamura, MD, Gen Suzuki, MD, Ken Yoshida, MD, Tadayuki Kotsuma, MD, Yasuo Yoshioka, MD, Ryoongjin Oh, MD

Published in: Strahlentherapie und Onkologie | Issue 7/2017

Abstract

Objective

To examine the outcomes of reirradiation for recurrent head and neck cancers using different modalities.

Methods

This retrospective study included 26 patients who received charged particle radiotherapy (CP) and 150 who received photon radiotherapy (117 CyberKnife radiotherapy [CK] and 36 intensity-modulated radiotherapy [IMRT]). Inverse probability of treatment weighting (IPTW) involving propensity scores was used to reduce background selection bias.

Results

Higher prescribed doses were used in CP than photon radiotherapy. The 1‑year overall survival (OS) rates were 67.9% for CP and 54.1% for photon radiotherapy (p = 0.15; 55% for CK and 51% for IMRT). In multivariate Cox regression, the significant prognostic factors for better survival were nasopharyngeal cancer, higher prescribed dose, and lower tumor volume. IPTW showed a statistically significant difference between CP and photon radiotherapy (p = 0.04). The local control rates for patients treated with CP and photon radiotherapy at 1 year were 66.9% (range 46.3–87.5%) and 67.1% (range 58.3–75.9%), respectively. A total of 48 patients (27%) experienced toxicity grade ≥3 (24% in the photon radiotherapy group and 46% in the CP group), including 17 patients with grade 5 toxicity. Multivariate analysis revealed that younger age and a larger planning target volume (PTV) were significant risk factors for grade 3 or worse toxicity.

Conclusion

CP provided superior survival outcome compared to photon radiotherapy. Tumor volume, primary site (nasopharyngeal), and prescribed dose were identified as survival factors. Younger patients with a larger PTV experienced toxicity grade ≥3.

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Title: Reirradiation for recurrent head and neck cancers using charged particle or photon radiotherapy
Authors: Hideya Yamazaki, MD
Yusuke Demizu, MD
Tomoaki Okimoto, MD
Mikio Ogita, MD
Kengo Himei, MD
Satoaki Nakamura, MD
Gen Suzuki, MD
Ken Yoshida, MD
Tadayuki Kotsuma, MD
Yasuo Yoshioka, MD
Ryoongjin Oh, MD
Publication date: 01-07-2017
Publisher: Springer Berlin Heidelberg
Published in: Strahlentherapie und Onkologie / Issue 7/2017
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-017-1129-6

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Reirradiation for recurrent head and neck cancers using charged particle or photon radiotherapy

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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