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01-02-2014 | Original article

Particle therapy for mucosal melanoma of the head and neck

A single-institution retrospective comparison of proton and carbon ion therapy

Authors: Y. Demizu, M.D., Ph.D., O. Fujii, K. Terashima, M. Mima, N. Hashimoto, Y. Niwa, T. Akagi, T. Daimon, M. Murakami, N. Fuwa

Published in: Strahlentherapie und Onkologie | Issue 2/2014

Abstract

Purpose

To retrospectively analyze treatment outcomes after particle therapy using protons or carbon ions for mucosal melanoma of the head and neck (HNMM) at the Hyogo Ion Beam Medical Center, as well as to compare proton therapy (PT) and carbon ion therapy (CIT).

Patients and methods

Data from 62 HNMM patients without metastasis, treated with PT or CIT between October 2003 and April 2011 were analyzed. Median patient age was 70.5 years (range 33–89 years). Of the total patients, 33 (53 %) had received PT and 29 (47 %) had undergone CIT. Protocols for 65 or 70.2 GyE in 26 fractions were used for both ion types.

Results

Median follow-up was 18.0 months (range 5.2–82.7 months). The 1-/2-year overall survival (OS) and local control (LC) rates were 93 %/61 % and 93 %/78 % for all patients, 91 %/44 % and 92 %/71 % for the PT patients and 96 %/62 % and 95 %/59 % for the CIT patients, respectively. No significant differences were observed between PT and CIT. Local recurrence was observed in 8 patients (PT: 5, CIT: 3) and 29 (PT: 18, CIT: 11) experienced distant metastases. Acute reactions were acceptable and all patients completed the planned radiotherapy. Regarding late toxicity, grade 3 or greater events were observed in 5 patients (PT: 3, CIT: 2), but no significant difference was observed between PT and CIT.

Conclusion

Our single-institution retrospective analysis demonstrated that particle therapy for HNMM achieved good LC, but OS was unsatisfactory. There were no significant differences between PT and CIT in terms of either efficacy or toxicity.

The particle beam dose is reported in Gray equivalents (GyE), which is the physical dose multiplied by the relative biological effectiveness (RBE) of the protons or carbon ions. Biological effects of both PT and CIT at HIBMC were evaluated in vitro and in vivo and the RBE values for proton and carbon ion irradiation were determined to be 2–3.7 (depending on the depth in the spread-out Bragg peaks) and 1.1, respectively [5].

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Title: Particle therapy for mucosal melanoma of the head and neck
A single-institution retrospective comparison of proton and carbon ion therapy
Authors: Y. Demizu, M.D., Ph.D.
O. Fujii
K. Terashima
M. Mima
N. Hashimoto
Y. Niwa
T. Akagi
T. Daimon
M. Murakami
N. Fuwa
Publication date: 01-02-2014
Publisher: Springer Berlin Heidelberg
Published in: Strahlentherapie und Onkologie / Issue 2/2014
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-013-0489-9

At a glance: The STEP trials

Springer Medicine

Particle therapy for mucosal melanoma of the head and neck

A single-institution retrospective comparison of proton and carbon ion therapy

Abstract

Purpose

Patients and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Patients and methods

Results

Conclusion

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