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Inflammation Research
Published in: Inflammation Research 1/2019

01-01-2019 | Short Communication

Altered regulation of the T-cell system in patients with CRPS

Authors: Jens Heyn, Shahnaz C. Azad, Benjamin Luchting

Published in: Inflammation Research | Issue 1/2019

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Abstract

The aim of this study was to investigate T-cell subsets and immunomodulatory factors in patients with complex regional pain syndrome (CRPS). We found decreased numbers of pro-inflammatory Th17 cells in patients with CRPS as compared to healthy volunteers. The expression of Th17 related RORγT mRNA was also significantly decreased. Patients with CRPS showed an increased proportion of CD39+ Tregs. CD39 is a known inhibitor of Th17 cell differentiation. Systemic cytokine levels were almost unchanged in patients with CRPS. These findings suggest that the decrease in Th17 cells in CRPS is regulated by an increase in CD39+ Tregs and that this anti-inflammatory T-cell shift may be a mechanism to control inflammation in CRPS.

German clinical trial register

Registration Trial DRKS00005954.
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Metadata
Title
Altered regulation of the T-cell system in patients with CRPS
Authors
Jens Heyn
Shahnaz C. Azad
Benjamin Luchting
Publication date
01-01-2019
Publisher
Springer International Publishing
Published in
Inflammation Research / Issue 1/2019
Print ISSN: 1023-3830
Electronic ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-018-1182-3

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