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01-05-2012 | Original Research Paper

Contribution of gender and body fat distribution to inflammatory marker concentrations in apparently healthy young adults

Authors: Helen Hermana M. Hermsdorff, Ana Carolina P. Volp, Blanca Puchau, Kiriaque B. F. Barbosa, M. Ángeles Zulet, Josefina Bressan, J. Alfredo Martínez

Published in: Inflammation Research | Issue 5/2012

Abstract

Objective

This cross-sectional study assessed the potential contribution of gender, body fat distribution, and their interactions to some inflammatory marker concentrations [C-reactive protein (CRP), complement factor 3 (C3), and ceruloplasmin (Cp)] in young adults.

Methods

Measurements included body composition, lifestyle features, blood biochemical and selected inflammatory markers on 317 healthy subjects [122 males/195 females; 22 ± 3 years; 22.1 ± 2.8 kg/m² (mean ± SD)].

Results

Women had significantly higher CRP and Cp concentrations than men. No gender difference was noted in C3 concentrations. In a multivariate model of the whole sample, body fat (BF), waist circumference (WC) and the sex × WC interaction term presented the highest R ² for variance of CRP (11%), C3 (2%), and Cp (12%), respectively. In regression models separated by sex, BF was the adiposity indicator that explained the variability of CRP in men (13%) and women (7%). WC was the only variable significantly associated with C3 concentrations in women (3%). BF presented the highest partial R ² for Cp in men (8%) and WC in women (16%).

Conclusion

Our findings indicate a relevant interaction between gender and body fat distribution on the variance of CRP, C3, and Cp concentrations in apparently healthy young adults.

Moreno-Aliaga MJ, Campión J, Milagro FI, Berjón A, Martínez JA. Adiposity and proinflammatory state: the chicken or the egg. Adipocytes. 2005;1:1–16.

Volp AC, Alfenas Rde C, Costa NM, Minim VP, Stringueta PC, Bressan J. Inflammation biomarkers capacity in predicting the metabolic syndrome. Arq Bras Endocrinol Metabol. 2008;52:537–49.PubMedCrossRef

Zulet MA, Puchau B, Navarro C, Marti A, Martínez JA. Inflammatory biomarkers: the link between obesity and associated pathologies. Nutr Hosp. 2007;22:511–27.PubMed

Engström G, Hedblad B, Eriksson KF, Janzon L, Lindgarde F. Complement C3 is a risk factor for the development of diabetes: a population-based cohort study. Diabetes. 2005;54:570–5.PubMedCrossRef

Festa A, D’Agostino R Jr, Williams K, Karter AJ, Mayer-Davis EJ, Tracy RP, et al. The relation of body fat mass and distribution to markers of chronic inflammation. Int J Obes Relat Metab Disord. 2001;25:1407–15.PubMedCrossRef

Kim OY, Shin MJ, Moon J, Chung JH. Plasma ceruloplasmin as a biomarker for obesity: a proteomic approach. Clin Biochem. 2011;44:351–6.PubMedCrossRef

Puchau B, Zulet MA, González de Echavarri A, Navarro-Blasco I, Martínez JA. Selenium intake reduces serum C3, an early marker of metabolic syndrome manifestations, in healthy young adults. Eur J Clin Nutr. 2009;63:858–64.PubMedCrossRef

Choi EY, Park EH, Cheong YS, Rheem I, Park SG, Yoo S. Association of C-reactive protein with the metabolic risk factors among young and middle-aged Koreans. Metabolism. 2006;55:415–21.PubMedCrossRef

Engström G, Hedblad B, Tyden P, Lindgarde F. Inflammation-sensitive plasma proteins are associated with increased incidence of heart failure: a population-based cohort study. Atherosclerosis. 2009;202:617–22.PubMedCrossRef

10.

Wang B, Li Q, Jiang Y, Liu Z, Zhong L, Luo R, et al. Serum complement C3 has a stronger association with insulin resistance than high sensitive C-reactive protein in non-diabetic Chinese. Inflamm Res. 2011;60:63–8.PubMedCrossRef

11.

Baumann H, Gauldie J. Regulation of hepatic acute phase plasma protein genes by hepatocyte stimulating factors and other mediators of inflammation. Mol Biol Med. 1990;7:147–59.PubMed

12.

Eder K, Baffy N, Falus A, Fulop AK. The major inflammatory mediator interleukin-6 and obesity. Inflamm Res. 2009;58:727–36.PubMedCrossRef

13.

Hermsdorff HHM, Puchau B, Zulet MA, Martínez JA. Association of body fat distribution with proinflammatory gene expression in peripheral blood mononuclear cells from young adult subjects. OMICS. 2010;14:297–307.PubMedCrossRef

14.

Hermsdorff HHM, Zulet MA, Puchau B, Martínez JA. Central adiposity rather than total adiposity measurements are specifically involved in the inflammatory status from healthy young adults. Inflammation. 2011;34:161–70.PubMedCrossRef

15.

Lapice E, Maione S, Patti L, Cipriano P, Rivellese AA, Riccardi G, et al. Abdominal adiposity is associated with elevated C-reactive protein independent of BMI in healthy nonobese people. Diabetes Care. 2009;32:1734–6.PubMedCrossRef

16.

Forsythe LK, Wallace JM, Livingstone MB. Obesity and inflammation: the effects of weight loss. Nutr Res Rev. 2008;21:117–33.PubMedCrossRef

17.

Hermsdorff HHM, Zulet MA, Bressan J, Martínez-González MA, Martínez JA. Impact of caloric restriction and Mediterranean food-based diets on inflammation accompanying obesity and metabolic syndrome features. Obes Metab. 2009;5:69–77.

18.

Vague J. Sexual differentiation. A determinant factor of the forms of obesity. 1947. Obes Res. 1996;4:201–3.PubMed

19.

Lemieux S, Prud’homme D, Bouchard C, Tremblay A, Després JP. Sex differences in the relation of visceral adipose tissue accumulation to total body fatness. Am J Clin Nutr. 1993;58:463–7.PubMed

20.

Cartier A, Cote M, Lemieux I, Perusse L, Tremblay A, Bouchard C, et al. Sex differences in inflammatory markers: what is the contribution of visceral adiposity? Am J Clin Nutr. 2009;89:1307–14.PubMedCrossRef

21.

Leung J, Jayachandran M, Kendall-Thomas J, Behrenbeck T, Araoz P, Miller VM. Pilot study of sex differences in chemokine/cytokine markers of atherosclerosis in humans. Gend Med. 2008;5:44–52.PubMedCrossRef

22.

Pou KM, Massaro JM, Hoffmann U, Vasan RS, Maurovich-Horvat P, Larson MG, et al. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation. 2007;116:1234–41.PubMedCrossRef

23.

Saltevo J, Vanhala M, Kautiainen H, Kumpusalo E, Laakso M. Gender differences in C-reactive protein, interleukin-1 receptor antagonist and adiponectin levels in the metabolic syndrome: a population-based study. Diabet Med. 2008;25:747–50.PubMedCrossRef

24.

Hermsdorff HHM, Zulet MA, Puchau B, Bressan J, Martínez JA. Association of retinol-binding protein-4 with dietary selenium intake and other lifestyle features in young healthy women. Nutrition. 2009;25:392–9.PubMedCrossRef

25.

Pérez S, Parra MD, Martínez de Morentin B, Rodríguez MC, Martínez JA. Evaluación de la variabilidad intraindividual de la medida de composición corporal mediante bioimpedancia en voluntarias sanas y su relación con el índice de masa corporal y el pliegue tricipital. Enferm Clin. 2005;15:307–14.CrossRef

26.

World Health Organization (WHO). Programme of nutrition, family and reproductive health. obesity. Preventing and managing the global epidemic. Report of a WHO consultation on obesity. Geneva, 1997. 1998.

27.

Durnin JV, Womersley J. Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr. 1974;32:77–97.PubMedCrossRef

28.

Siri WE. The gross composition of the body. Adv Biol Med Phys. 1956;4:239–80.PubMed

29.

Whitworth JA, Chalmers J. World health organisation-international society of hypertension (WHO/ISH) hypertension guidelines. Clin Exp Hypertens. 2004;26:747–52.PubMedCrossRef

30.

Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–9.PubMedCrossRef

31.

Castelli WP. Cholesterol and lipids in the risk of coronary artery disease—the Framingham Heart Study. Can J Cardiol 1988; 4 Suppl A:5A–10A.

32.

Willett WC. Nutritional epidemiology. New York: Oxford University Press; 1998.CrossRef

33.

Hermsdorff HHM, Monteiro JB. Visceral, subcutaneous or intramuscular fat: where is the problem? Arq Bras Endocrinol Metabol. 2004;48:803–11.PubMedCrossRef

34.

Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature. 2006;444:875–80.PubMedCrossRef

35.

Hermsdorff HHM, Zulet MA, Abete I, Martínez JA. Discriminated benefits of a Mediterranean dietary pattern within a hypocaloric diet program on plasma RBP4 concentrations and other inflammatory markers in obese subjects. Endocrine. 2009;36:445–51.PubMedCrossRef

36.

Hermsdorff HHM, Zulet MA, Abete I, Martínez JA. A legume-based hypocaloric diet reduces proinflammatory status and improves metabolic features in overweight/obese subjects. Eur J Nutr. 2011;50:61–9.PubMedCrossRef

37.

Lee IS, Shin G, Choue R. A 12-week regimen of caloric restriction improves levels of adipokines and pro-inflammatory cytokines in Korean women with BMIs greater than 23 kg/m². Inflamm Res. 2010;59:399–405.PubMedCrossRef

38.

Nishida M, Moriyama T, Sugita Y, Yamauchi-Takihara K. Abdominal obesity exhibits distinct effect on inflammatory and anti-inflammatory proteins in apparently healthy Japanese men. Cardiovasc Diabetol. 2007;6:27.PubMedCrossRef

39.

Santos AC, Lopes C, Guimaraes JT, Barros H. Central obesity as a major determinant of increased high-sensitivity C-reactive protein in metabolic syndrome. Int J Obes (Lond). 2005;29:1452–6.CrossRef

40.

Cignarelli M, DePergola G, Picca G, Sciaraffia M, Pannacciulli N, Tarallo M, et al. Relationship of obesity and body fat distribution with ceruloplasmin serum levels. Int J Obes Relat Metab Disord. 1996;20:809–13.PubMed

41.

Khera A, Vega GL, Das SR, Ayers C, McGuire DK, Grundy SM, et al. Sex differences in the relationship between C-reactive protein and body fat. J Clin Endocrinol Metab. 2009;94:3251–8.PubMedCrossRef

42.

Després JP, Allard C, Tremblay A, Talbot J, Bouchard C. Evidence for a regional component of body fatness in the association with serum lipids in men and women. Metabolism. 1985;34:967–73.PubMedCrossRef

43.

Onat A, Hergenc G, Can G, Kaya Z, Yuksel H. Serum complement C3: a determinant of cardiometabolic risk, additive to the metabolic syndrome, in middle-aged population. Metabolism. 2009;59:628–34.PubMedCrossRef

44.

Regitz-Zagrosek V, Lehmkuhl E, Mahmoodzadeh S. Gender aspects of the role of the metabolic syndrome as a risk factor for cardiovascular disease. Gend Med 2007; 4 Suppl B:S162–S177.

45.

Saltevo J, Kautiainen H, Vanhala M. Gender differences in adiponectin and low-grade inflammation among individuals with normal glucose tolerance, prediabetes, and type 2 diabetes. Gend Med. 2009;6:463–70.PubMedCrossRef

46.

Johnson PE, Milne DB, Lykken GI. Effects of age and sex on copper absorption, biological half-life, and status in humans. Am J Clin Nutr. 1992;56:917–25.PubMed

47.

Wener MH, Daum PR, McQuillan GM. The influence of age, sex, and race on the upper reference limit of serum C-reactive protein concentration. J Rheumatol. 2000;27:2351–9.PubMed

48.

Garmizo G, Frauens BJ. Corneal copper deposition secondary to oral contraceptives. Optom Vis Sci. 2008;85:E802–7.PubMedCrossRef

49.

van Rooijen M, Hansson LO, Frostegard J, Silveira A, Hamsten A, Bremme K. Treatment with combined oral contraceptives induces a rise in serum C-reactive protein in the absence of a general inflammatory response. J Thromb Haemost. 2006;4:77–82.PubMedCrossRef

Title: Contribution of gender and body fat distribution to inflammatory marker concentrations in apparently healthy young adults
Authors: Helen Hermana M. Hermsdorff
Ana Carolina P. Volp
Blanca Puchau
Kiriaque B. F. Barbosa
M. Ángeles Zulet
Josefina Bressan
J. Alfredo Martínez
Publication date: 01-05-2012
Publisher: SP Birkhäuser Verlag Basel
Published in: Inflammation Research / Issue 5/2012
Print ISSN: 1023-3830
Electronic ISSN: 1420-908X
DOI: https://doi.org/10.1007/s00011-011-0429-z

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Contribution of gender and body fat distribution to inflammatory marker concentrations in apparently healthy young adults

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Methods

Results

Conclusion

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