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Journal of Endocrinological Investigation
Published in: Journal of Endocrinological Investigation 10/2015

01-10-2015 | Opinion

PseudoCushing: why a clinical challenge?

Author: F. Pecori Giraldi

Published in: Journal of Endocrinological Investigation | Issue 10/2015

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Excerpt

Any clinician who deals with obese, depressed, and ruddy-faced individuals has certainly faced the quandary as to whether the patient presents Cushing’s syndrome or more simply pseudoCushing. This distinction presents a significant clinical challenge for even the most expert endocrinologist due to a variety of reasons, comprising overlap in clinical and laboratory alterations, skewed epidemiology, and insufficient accuracy of diagnostic procedures. …
Literature
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Veldman RG, Meinders AE (1996) On the mechanism of alcohol-induced pseudo-Cushing’s syndrome. Endocr Rev 17:262–268CrossRef
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Pecori Giraldi F, Moro M, Cavagnini F, The Study Group of the Italian Society of Endocrinology on the Pathophysiology of the Hypothalamic-Pituitary-Adrenal Axis (2003) Gender-related differences in the presentation and course of Cushing’s disease. J Clin Endocrinol Metab 88:1554–1558CrossRefPubMed
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Kreitschmann-Andermahr I, Psaras T, Tsiogka M et al (2015) From first symptoms to final diagnosis of Cushing’s disease: experiences of 176 patients. Eur J Endocrinol 172:285–289CrossRefPubMed
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Ross EJ, Linch DC (1982) Cushing’s syndrome—a killing disease: discriminatory value of signs and symptoms aiding early diagnosis. Lancet II:646–649CrossRef
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Papanicolaou DA, Yanovski JA, Cutler GB Jr, Chrousos GP, Nieman LK (1998) A single midnight serum cortisol measurement distinguishes Cushing’s syndrome from pseudo-Cushing states. J Clin Endocrinol Metab 83:1163–1167PubMed
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Reimondo G, Pia A, Bovio S et al (2008) Laboratory differentiation of Cushing’s syndrome. Clin Chim Acta 388:5–14CrossRefPubMed
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Pecori Giraldi F, Ambrogio AG, De Martin M, Fatti LM, Scacchi M, Cavagnini F (2007) Specificity of first-line tests for the diagnosis of Cushing’s syndrome: assessment in a large series. J Clin Endocrinol Metab 92:4123–4129CrossRefPubMed
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Newell-Price J, Trainer PJ, Besser GM, Grossman AB (1998) The diagnosis and differential diagnosis of Cushing’s syndrome and Pseudo-Cushing’s states. Endocrine Rev 19:647–672
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Findling JW, Raff H (2006) Cushing’s syndrome: important issues in diagnosis and management. J Clin Endocrinol Metab 91:3746–3753CrossRefPubMed
Metadata
Title
PseudoCushing: why a clinical challenge?
Author
F. Pecori Giraldi
Publication date
01-10-2015
Publisher
Springer International Publishing
Published in
Journal of Endocrinological Investigation / Issue 10/2015
Electronic ISSN: 1720-8386
DOI
https://doi.org/10.1007/s40618-015-0296-5

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