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Open Access 18-03-2023 | Photodynamic Therapy | REVIEW

Yellow Subthreshold Micropulse Laser in Retinal Diseases: An In-Depth Analysis and Review of the Literature

Authors: Claudio Iovino, Clemente Maria Iodice, Danila Pisani, Andrea Rosolia, Francesco Testa, Giuseppe Giannaccare, Jay Chhablani, Francesca Simonelli

Published in: Ophthalmology and Therapy | Issue 3/2023

Abstract

Yellow subthreshold micropulse laser (YSML) is a retinal laser capable of inducing a biologic response without causing thermal damage to the targeted tissue. The 577-nm YSML is delivered to the retina abiding by different protocols in which wavelength, power, duration, spot size and number of spots can be properly set to achieve the most effective and safe treatment response in various chorioretinal disorders. The ultrashort trains of power modulate the activation of the retinal pigment epithelium cells and intraretinal cells, such as Müller cells, causing no visible retinal scars. Subthreshold energy delivered by YSML stimulates the production of the heat-shock proteins, highly conserved molecules that protect cells against any sort of stress by blocking apoptotic and inflammatory pathways that cause cell damage. YSML treatment allows resorption of the subretinal fluid in central serous chorioretinopathy and intraretinal fluid in various conditions including diabetic macular edema, postoperative cystoid macular edema and other miscellaneous conditions. YSML also seems to modulate the development and progression of reticular pseudodrusen in dry age-related macular degeneration. The aim of this review is to discuss and summarize the safety and efficacy of YSML treatment in retinal diseases.

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Title: Yellow Subthreshold Micropulse Laser in Retinal Diseases: An In-Depth Analysis and Review of the Literature
Authors: Claudio Iovino
Clemente Maria Iodice
Danila Pisani
Andrea Rosolia
Francesco Testa
Giuseppe Giannaccare
Jay Chhablani
Francesca Simonelli
Publication date: 18-03-2023
Publisher: Springer Healthcare
Keywords: Photodynamic Therapy
Retinal Diseases
Laser
Published in: Ophthalmology and Therapy / Issue 3/2023
Print ISSN: 2193-8245
Electronic ISSN: 2193-6528
DOI: https://doi.org/10.1007/s40123-023-00698-w

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