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Cellular Oncology
Published in: Cellular Oncology 2/2017

01-04-2017 | Review

Emerging diagnostic, prognostic and therapeutic biomarkers for ovarian cancer

Authors: Khalid El Bairi, Abdul Hafeez Kandhro, Adel Gouri, Wafaa Mahfoud, Noureddine Louanjli, Brahim Saadani, Said Afqir, Mariam Amrani

Published in: Cellular Oncology | Issue 2/2017

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Abstract

Background

In spite of various treatment options currently available, ovarian cancer (OC) still remains a leading cause of death in women world-wide. Diagnosis at an early stage is one of the most important factors that determines survival. Current clinical diagnostic tools have, however, a limited efficacy in early OC detection. Therefore, there is a critical need for new (early) diagnostic biomarkers and tools. Through advances in genomic, proteomic and metabolomic techniques, several novel molecular OC biomarkers have recently been identified. These biomarkers are currently subject to validation. In addition, integration of genomic, proteomic and metabolomic data, in conjunction with epidemiologic and clinical data, is considered essential for obtaining useful results. Interesting recent work has already shown that specific diagnostic biomarkers, such as BRCA mutations, may have profound therapeutic implications. Here, we review the current state of OC research through literature and database searches, with a focus on various recently identified biomarkers via different technologies for the (early) diagnosis, prognosis and treatment of OC.

Conclusions

Multi-biomarker panels accompanied by a meticulous determination of their sensitivity and specificity, as well their validation, using multivariate analyses will be critical for its clinical application, including early OC detection and tailor-made OC treatment.
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Metadata
Title
Emerging diagnostic, prognostic and therapeutic biomarkers for ovarian cancer
Authors
Khalid El Bairi
Abdul Hafeez Kandhro
Adel Gouri
Wafaa Mahfoud
Noureddine Louanjli
Brahim Saadani
Said Afqir
Mariam Amrani
Publication date
01-04-2017
Publisher
Springer Netherlands
Published in
Cellular Oncology / Issue 2/2017
Print ISSN: 2211-3428
Electronic ISSN: 2211-3436
DOI
https://doi.org/10.1007/s13402-016-0309-1

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