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01-03-2012 | Review and Perspectives

Ovarian carcinomas: five distinct diseases with different origins, genetic alterations, and clinicopathological features

Author: Jaime Prat

Published in: Virchows Archiv | Issue 3/2012

Abstract

Malignant epithelial tumors (carcinomas) are the most common ovarian cancers and also the most lethal gynecological malignancies. Based on histopathology and molecular genetic alterations, ovarian carcinomas are divided into five main types (high-grade serous (70%), endometrioid (10%), clear cell (10%), mucinous (3%), and low-grade serous carcinomas (<5%)) that account for over 95% of cases. These types are essentially distinct diseases, as indicated by differences in epidemiological and genetic risk factors, precursor lesions, patterns of spread, and molecular events during oncogenesis, response to chemotherapy, and prognosis. For a successful specific treatment, reproducible histopathological diagnosis of the tumor cell type is critical. The five tumor types are morphologically diverse and resemble carcinomas of the uterus. Actually, recent investigations have demonstrated that a significant number of cancers, traditionally thought to be primary ovarian tumors (particularly serous, endometrioid, and clear cell carcinomas), originate in the fallopian tube and the endometrium and involve the ovary secondarily. This review summarizes recent advances in the molecular pathology which have greatly improved our understanding of the biology of ovarian carcinoma and are also relevant to patient management.

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Title: Ovarian carcinomas: five distinct diseases with different origins, genetic alterations, and clinicopathological features
Author: Jaime Prat
Publication date: 01-03-2012
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 3/2012
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-012-1203-5

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Ovarian carcinomas: five distinct diseases with different origins, genetic alterations, and clinicopathological features

Abstract

At a glance: The ONWARDS insulin icodec trials

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Abstract

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