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01-02-2016 | Review Article

Cofilin as a Promising Therapeutic Target for Ischemic and Hemorrhagic Stroke

Authors: Qasim Alhadidi, Muhammad Shahdaat Bin Sayeed, Zahoor A. Shah

Published in: Translational Stroke Research | Issue 1/2016

Abstract

Neurovascular unit (NVU) is considered as a conceptual framework for investigating the mechanisms as well as developing therapeutic targets for ischemic and hemorrhagic stroke. From a molecular perspective, oxidative stress, excitotoxicity, inflammation, and disruption of the blood brain barrier are broad pathophysiological frameworks on the basis on which potential therapeutic candidates for ischemic and hemorrhagic stroke could be discussed. Cofilin is a potent actin-binding protein that severs and depolymerizes actin filaments in order to generate the dynamics of the actin cytoskeleton. Although studies of the molecular mechanisms of cofilin-induced reorganization of the actin cytoskeleton have been ongoing for decades, the multicellular functions of cofilin and its regulation in different molecular pathways are expanding beyond its primary role in actin cytoskeleton. This review focuses on the role of cofilin in oxidative stress, excitotoxicity, inflammation, and disruption of the blood brain barrier in the context of NVU as well as how and why cofilin could be studied further as a potential target for ischemic and hemorrhagic stroke.

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Title: Cofilin as a Promising Therapeutic Target for Ischemic and Hemorrhagic Stroke
Authors: Qasim Alhadidi
Muhammad Shahdaat Bin Sayeed
Zahoor A. Shah
Publication date: 01-02-2016
Publisher: Springer US
Published in: Translational Stroke Research / Issue 1/2016
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-015-0438-2

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Cofilin as a Promising Therapeutic Target for Ischemic and Hemorrhagic Stroke

Abstract

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