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Journal of Nuclear Cardiology
Published in: Journal of Nuclear Cardiology 5/2020

01-10-2020 | Cardiac Amyloidosis | Brief Report

Quantitative 99mTc-DPD SPECT/CT in patients with suspected ATTR cardiac amyloidosis: Feasibility and correlation with visual scores

Authors: Federico Caobelli, MD, FEBNM, Martin Braun, MD, Philip Haaf, MD, Damian Wild, MD, Michael J. Zellweger, MD

Published in: Journal of Nuclear Cardiology | Issue 5/2020

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Abstract

Purpose

While a visual interpretation of 99mTc-DPD scintigraphy by means of Perugini score can provide a reliable diagnosis of transthyretin-related (ATTR) cardiac amyloidosis (CA), a quantitative approach is expected to play a major role in risk stratification and therapy evaluation. The aim of our study was to test the feasibility of a quantitative assessment and to correlate various parameters to Perugini score.

Methods

in this retrospective study, consecutive patients underwent a 99mTc-DPD whole-body bone scintigraphy and a SPECT/CT of the thorax. XSPECT-QUANT software was used to quantify the DPD uptake in the heart.

Results

Thirteen patients were included. CA was confirmed in 8 and rejected in 5. Myocardial SUVmax and SUVpeak showed a fairly strong correlation with Perugini score (both ρ = .71, P = .006). Same held true for to-bone normalized values (both ρ = .75, P = .003). There was a great degree of overlap for quantitative values in patients with Perugini score 2 and 3.

Conclusion

Quantitative 99mTc-DPD SPECT/CT in suspected ATTR CA patients is feasible and allows for a more accurate assessment of myocardial uptake.
Appendix
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Metadata
Title
Quantitative 99mTc-DPD SPECT/CT in patients with suspected ATTR cardiac amyloidosis: Feasibility and correlation with visual scores
Authors
Federico Caobelli, MD, FEBNM
Martin Braun, MD
Philip Haaf, MD
Damian Wild, MD
Michael J. Zellweger, MD
Publication date
01-10-2020
Publisher
Springer International Publishing
Published in
Journal of Nuclear Cardiology / Issue 5/2020
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-019-01893-8

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