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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 13/2017

01-12-2017 | Editorial

What future for the myocardial sympathetic innervation imaging?

Author: Federico Caobelli

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 13/2017

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Excerpt

The myocardial sympathetic innervation plays a pivotal role in the progression of heart failure and in the occurrence of life-threatening arrhythmias. An impaired function of presynaptic sympathetic nerve terminals is considered to reflect impaired reuptake and thus impaired removal of the neurotransmitter from the synaptic cleft [1], resulting in overexposure of the myocardium to catecholamines and in a pre/post-synaptic signaling imbalance [2]. Consistent with this pathophysiologic model, prospective, large-scale clinical trials confirmed an excellent prognostic value of adrenergic imaging in patients with heart failure, both with single photon emission tomography (SPECT) and with positron emission tomography (PET) [3, 4]. …
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Metadata
Title
What future for the myocardial sympathetic innervation imaging?
Author
Federico Caobelli
Publication date
01-12-2017
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 13/2017
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-017-3847-5

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