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01-12-2018 | Editorial

Dual-isotope myocardial perfusion SPECT imaging: Past, present, and future

Authors: Tali Sharir, MD, Piotr Slomka, PhD

Published in: Journal of Nuclear Cardiology | Issue 6/2018

Excerpt

Myocardial perfusion SPECT imaging (MPI) is a widely available technique used to identify and quantify ischemia, infarct, and myocardial viability. The first radioisotope used was thallium (Tl)-201, introduced to nuclear medicine by Kawana et al in 1970,1 and evaluated for MPI shortly after.2 As a biologic analog of potassium, Tl-201 has the advantages of efficient myocardial extraction and rapid blood clearance, favoring its use as a myocardial perfusion agent. Accumulation of Tl-201 within ischemic zones is slower compared to non-ischemic regions, and reaches a peak after several hours. Thus, early post-Tl-201 injection images demonstrate flow, whereas delayed images demonstrate myocardial viability within the ischemic or infarcted zones. …

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Lebowitz E, Greene MW, Fairchild R, Bradley-Moore PR, Atkins HL, Ansari AN, et al. Thallium-201 for medical use. I. J Nucl Med. 1975;16:151-5.PubMed

Berman DS, Kiat HS, Van Train KF, Germano G, Maddahi J, Friedman JD. Myocardial perfusion imaging with technetium-99m-sestamibi: Comparative analysis of available imaging protocols. J Nucl Med. 1994;35:681-8.PubMed

Berman DS, Kiat H, Friedman JD, Wang FP, van Train K, Matzer L, et al. Separate acquisition rest thallium-201/stress technetium-99m sestamibi dual-isotope myocardial perfusion single-photon emission computed tomography: A clinical validation study. J Am Coll Cardiol. 1993;22:1455-64.CrossRefPubMed

Kiat H, Germano G, Friedman J, Van Train K, Silagan G, Wang FP, et al. Comparative feasibility of separate or simultaneous rest thallium-201/stress technetium-99 m-sestamibi dual-isotope myocardial perfusion SPECT. J Nucl Med. 1994;35:542-8.PubMed

Einstein AJ, Pascual TN, Mercuri M, Karthikeyan G, Vitola JV, Mahmarian JJ, et al. INCAPS Investigators Group. Current worldwide nuclear cardiology practices and radiation exposure: Results from the 65 country IAEA Nuclear Cardiology Protocols Cross-Sectional Study (INCAPS). Eur Heart J. 2015;36:1689-96.CrossRefPubMedPubMedCentral

Kacperski K, Erlandsson K, Ben-Haim S, Hutton BF. Iterative deconvolution of simultaneous 99mTc and 201Tl projection data measured on a CdZnTe-based cardiac SPECT scanner. Phys Med Biol. 2011;56:1397-414.CrossRefPubMedPubMedCentral

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Makita A, Matsumoto N, Suzuki Y, Hori Y, Kuronuma K, Yoda S, et al. Clinical feasibility of simultaneous acquisition rest (99m)Tc/stress (201)Tl dual-isotope myocardial perfusion single-photon emission computed tomography with semiconductor camera. Circ J. 2016;80:689-95.CrossRefPubMed

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Songy B, Lussato D, Guernou M, Queneau M, Geronazzo R. Comparison of myocardial perfusion imaging using thallium-201 between a new cadmium-zinc-telluride cardiac camera and a conventional SPECT camera. Clin Nucl Med. 2011;36:776-80.CrossRefPubMed

Title: Dual-isotope myocardial perfusion SPECT imaging: Past, present, and future
Authors: Tali Sharir, MD
Piotr Slomka, PhD
Publication date: 01-12-2018
Publisher: Springer US
Published in: Journal of Nuclear Cardiology / Issue 6/2018
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-017-0966-0

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