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Journal of Nuclear Cardiology

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01-02-2017 | Original Article

Right ventricular dyssynchrony in pulmonary hypertension: Phase analysis using FDG-PET imaging

Authors: Lei Wang, MD, Weihua Zhou, PhD, Yu Liang, MD, Yong Yang, MD, Ernest V. Garcia, PhD, Ji Chen, PhD, Wei Fang, MD

Published in: Journal of Nuclear Cardiology | Issue 1/2017

Abstract

Background

Right ventricular (RV) performance in patients of pulmonary hypertension (PH) requires optimal assessment. The objective of this study is to develop phase analysis using ¹⁸F-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging as a feasible tool for evaluation of RV dyssynchrony in PH.

Methods and Results

Fifty-four PH patients with well-characterized hemodynamic parameters were enrolled. All subjects performed FDG-PET imaging for RV phase analysis and RV function evaluation. Two-dimensional echocardiography with speckle tracking analysis was conducted to obtain RV time to peak systolic strain (PSST) as a comparison. The median contraction delay difference between RV middle free wall and septum measured by PET phase analysis (RVPD_PET) was 20.12° (interquartile range, 4.99°-30.10°). The median difference of PSST between RV middle free wall and middle septal wall (RVPD_Echo) measured by echocardiography was 43.98° (interquartile range, 6.25°-72.00°). RVPD_PET was well correlated with RVPD_Echo (r = 0.685, P < .001). RV phase standard deviation (RVSD) and histogram bandwidth (RVBW) derived from PET phase histogram were significantly correlated with cardiac index, RV ejection fraction, 6-minute walking distance, and serum N-terminal pro B-type natriuretic peptide (NT-proBNP) (RVSD: r = −0.532, P < .001; r = −0.551, P < .001; r = −0.544, P < .001; r = 0.404, P < .01; respectively, RVBW: r = −0.492, P < .001; r = −0.466, P < .001; r = −0.544, P < .001; r = 0.349, P = .01, respectively), while there were no significant correlations between RVSD and RVBW with hemodynamic parameters (right atrial pressure, right ventricular systolic pressure, right ventricular end-diastolic pressure, mean pulmonary artery pressure, and total pulmonary resistance).

Conclusions

Contraction delays between RV free wall and septum in PH measured by phase analysis and speckle tracking echocardiography were well correlated. RV dyssynchrony measured by phase analysis of FDG-PET was significantly related to RV dysfunction. Phase analysis of FDG-PET is feasible to evaluate RV mechanical dyssynchrony in patients of PH.

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Title: Right ventricular dyssynchrony in pulmonary hypertension: Phase analysis using FDG-PET imaging
Authors: Lei Wang, MD
Weihua Zhou, PhD
Yu Liang, MD
Yong Yang, MD
Ernest V. Garcia, PhD
Ji Chen, PhD
Wei Fang, MD
Publication date: 01-02-2017
Publisher: Springer US
Published in: Journal of Nuclear Cardiology / Issue 1/2017
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-015-0341-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Right ventricular dyssynchrony in pulmonary hypertension: Phase analysis using FDG-PET imaging

Abstract

Background

Methods and Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods and Results

Conclusions

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