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European Journal of Nuclear Medicine and Molecular Imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging 11/2011

Open Access 01-11-2011 | Original Article

Left ventricular diastolic dyssynchrony assessed with phase analysis of gated myocardial perfusion SPECT: a comparison with tissue Doppler imaging

Authors: Mark J. Boogers, Ji Chen, Caroline E. Veltman, Rutger J. van Bommel, Eline A. Q. Mooyaart, Imad Al Younis, Bernies van der Hiel, Petra Dibbets-Schneider, Ernst E. van der Wall, Martin J. Schalij, Ernest V. Garcia, Jeroen J. Bax, Victoria Delgado

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 11/2011

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Abstract

Purpose

The aim of the current study was to evaluate the feasibility of phase analysis on gated myocardial perfusion SPECT (GMPS) for the assessment of left ventricular (LV) diastolic dyssynchrony in a head-to-head comparison with tissue Doppler imaging (TDI).

Methods

The population consisted of patients with end-stage heart failure of New York Heart Association functional class III or IV with a reduced LV ejection fraction of ≤35%. LV diastolic dyssynchrony was calculated using TDI as the maximal time delay between early peak diastolic velocities of two opposing left ventricle walls (diastolic mechanical delay). Significant LV diastolic dyssynchrony was defined as a diastolic mechanical delay of >55 ms on TDI. Furthermore, phase analysis on GMPS was performed to evaluate LV diastolic dyssynchrony; diastolic phase standard deviation (SD) and histogram bandwidth (HBW) were used as markers of LV diastolic dyssynchrony.

Results

A total of 150 patients (114 men, mean age 66.0 ± 10.4 years) with end-stage heart failure were enrolled. Both diastolic phase SD (r = 0.81, p < 0.01) and diastolic HBW (r = 0.75, p < 0.01) showed good correlations with LV diastolic dyssynchrony on TDI. Additionally, patients with LV diastolic dyssynchrony on TDI (>55 ms) showed significantly larger diastolic phase SD (68.1 ± 13.4° vs. 40.7 ± 14.0°, p < 0.01) and diastolic HBW (230.6 ± 54.3° vs. 129.0 ± 55.6°, p < 0.01) as compared to patients without LV diastolic dyssynchrony on TDI (≤55 ms). Finally, phase analysis on GMPS showed a good intra- and interobserver reproducibility for the determination of diastolic phase SD (ICC 0.97 and 0.88) and diastolic HBW (ICC 0.98 and 0.93).

Conclusion

Phase analysis on GMPS showed good correlations with TDI for the assessment of LV diastolic dyssynchrony.
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Metadata
Title
Left ventricular diastolic dyssynchrony assessed with phase analysis of gated myocardial perfusion SPECT: a comparison with tissue Doppler imaging
Authors
Mark J. Boogers
Ji Chen
Caroline E. Veltman
Rutger J. van Bommel
Eline A. Q. Mooyaart
Imad Al Younis
Bernies van der Hiel
Petra Dibbets-Schneider
Ernst E. van der Wall
Martin J. Schalij
Ernest V. Garcia
Jeroen J. Bax
Victoria Delgado
Publication date
01-11-2011
Publisher
Springer-Verlag
Published in
European Journal of Nuclear Medicine and Molecular Imaging / Issue 11/2011
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-011-1870-5

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