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Clinical Journal of Gastroenterology
Published in: Clinical Journal of Gastroenterology 4/2023

26-04-2023 | Helicobacter Pylori | Case Report

Synchronous gastric MALT lymphoma and gastric adenocarcinoma of fundic gland type arising from a hamartomatous inverted polyp in a Helicobacter pylori naive patient

Authors: Ryo Miyamoto, Hidehiko Takigawa, Takahiro Kotachi, Hiroki Kadota, Ryo Yuge, Ryohei Hayashi, Yuji Urabe, Akira Ishikawa, Kazuhiro Sentani, Shiro Oka

Published in: Clinical Journal of Gastroenterology | Issue 4/2023

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Abstract

We present a rare case that showed the coexistence of gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma in Helicobacter pylori-naive stomach. A 72-year-old man was followed up after surgery for epithelial carcinoma of the glottis at the Department of Otolaryngology. He underwent an upper gastrointestinal endoscopy for an abnormal PET-CT accumulation, which revealed gastric adenocarcinoma of fundic gland type in the gastric fundus and MALT lymphoma in the upper gastric body. Hence, we performed an endoscopic submucosal dissection for gastric cancer and diagnosed gastric adenocarcinoma of fundic gland type derived from a hamartomatous–inverted polyp. Subsequently, Gastric MALT lymphoma was treated with radiation therapy because the API2-MALT1 gene was positive and the Helicobacter pylori infection was negative. A complete response was observed. Even in Hp-naive stomachs, cases such as the present case are complicated by special types of gastric cancer and MALT lymphoma, and endoscopic examination should be performed with these diseases in mind.
Literature
1.
Uemura N, Okamoto S, Yamamoto S, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001;345:784–9.CrossRefPubMed
2.
Matsuo T, Ito M, Takata S, et al. Low prevalence of Helicobacter pylori-negative gastric cancer among Japanese. Helicobacter. 2011;16:415–9.CrossRefPubMed
3.
Ueyama H, Yao T, Nakashima Y, et al. Gastric adenocarcinoma of fundic gland type (chief cell predominant type): proposal for a new entity of gastric adenocarcinoma. Am J Surg Pathol. 2010;34:609–19.CrossRefPubMed
4.
Isaacson PG, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue A distinctive type of B-cell lymphoma. Cancer. 1983;52:1410–6.CrossRefPubMed
5.
Wotherspoon AC, Doglioni C, Diss TC, et al. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet. 1993;342:575–7.CrossRefPubMed
6.
Nakamura S, Sugiyama T, Matsumoto T, et al. Long–term clinical outcome of gastric MALT lymphoma after eradication of Helicobacter pylori: a multicentre cohort follow–up study of 420 patients in Japan. Gut. 2012;61:507–13.CrossRefPubMed
7.
Ishihama T, Kondo H, Saito D, et al. Clinicopathological studies on coexisting gastric malignant lymphoma and gastric adenocarcinoma: report of four cases and review of the Japanese literature. Jpn J Clin Oncol. 1997;27:101–6.CrossRefPubMed
8.
Sakai T, Ogura Y, Narita J, et al. Simultaneous early adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach associated with Helicobacter pylori infection. Gastric Cancer. 2003;6:191–6.CrossRefPubMed
9.
10.
Takigawa H, Yuge R, Masaki S, et al. Involvement of non-Helicobacter pylori helicobacter infections in Helicobacter pylori-negative gastric MALT lymphoma pathogenesis and efficacy of eradication therapy. Gastric Cancer. 2021;24:937–45.CrossRefPubMed
11.
Asano N, Iijima K, Koike T, et al. Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphomas: a review. World J Gastroenterol. 2015;21:8014–20.CrossRefPubMedPubMedCentral
12.
Noda T, Akashi H, Matsueda S, et al. Collision of malignant lymphoma and multiple early adenocarcinomas of the stomach. Arch Pathol Lab Med. 1989;113:419–22.PubMed
13.
Nakamura S, Aoyagi K, Iwanaga S, et al. Synchronous and metachronous primary gastric lymphoma and adenocarcinoma: a clinicopathological study of 12 patients. Cancer. 1997;79:1077–85.CrossRefPubMed
14.
Hamabe A, Omori T, Oyama T, et al. A Helicobacter pylori infection complicated with gastric cancer, gastric mucosa-associated lymphoid tissue lymphoma, and idiopathic thrombocytopenic purpura was successfully treated with laparoscopy-assisted total gastrectomy and splenectomy. Asian J Endosc Surg. 2011;4:32–5.CrossRefPubMed
15.
Suenaga M, Ohta K, Toguchi M, et al. Colliding gastric and intestinal phenotype well-differentiated adenocarcinoma of the stomach developing in an area of MALT-type lymphoma. Gastric Cancer. 2003;6:270–6.CrossRefPubMed
16.
Akiba J, Nakane T, Arakawa F, et al. Collision of EBV-associated gastric carcinoma and primary gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in the remnant stomach. Pathol Int. 2010;60:102–6.CrossRefPubMed
17.
Kanamoto K, Aoyagi K, Nakamura S, et al. Simultaneous coexistence of early adenocarcinoma and low-grade MALT lymphoma of the stomach associated with Helicobacter pylori infection: a case report. Gastrointest Endosc. 1998;47:73–5.CrossRefPubMed
18.
Raderer M, Streubel B, Wöhrer S, et al. Metachronous gastric MALT lymphoma and early gastric cancer. Ann Oncol. 2006;17:724.CrossRefPubMed
19.
Raderer M, Püspök A, Stummvoll G, et al. Early cancer of the stomach arising after successful treatment of gastric MALT lymphoma in patients with autoimmune disease. Scand J Gastroenterol. 2003;38:294–7.CrossRefPubMed
20.
Amiot A, Jooste V, Gagniere C, et al. Second primary malignancies in patients treated for gastric mucosa-associated lymphoid tissue lymphoma. Leuk Lymphoma. 2017;58:2057–64.CrossRef
21.
Imamura K, Yao K, Nimura S, et al. Characteristic endoscopic findings of gastric adenocarcinoma of fundic-gland mucosa type. Gastric Cancer. 2021;24:1307–19.CrossRefPubMed
22.
Yamashita M, Hirokawa M, Nakasono M, et al. Gastric inverted hyperplastic polyp Report of four cases and relation to gastritis cystica profunda. APMIS. 2002;110:717–23.CrossRefPubMed
23.
24.
Gurzu S, Sugimura H, Orlowska J, et al. New insights in histogenetic pathways of gastric cancer. Med (Baltim). 2015;94:e1810.CrossRef
25.
Takahashi K, Fujiya M, Ichihara S, et al. Inverted gastric adenocarcinoma of fundic gland mucosa type colliding with well-differentiated adenocarcinoma: case a report. Medicine. 2017;96:e7080.CrossRefPubMedPubMedCentral
26.
Okamura T, Iwaya Y, Nagaya T, et al. Gastric adenocarcinoma arising from hamartomatous–inverted polyp during 8-year follow-up. DEN Open. 2022;2:e16.CrossRefPubMed
27.
Yamamoto M, Nishida T, Nakamatsu D, et al. Endoscopic findings of inverted pyloric gland adenoma resected by endoscopic submucosal dissection. J Gastrointestin Liver Dis. 2018;27:361.CrossRefPubMed
28.
Kim GH, Lee MW, Lee BE, et al. Endoscopic submucosal dissection of an inverted pyloric gland adenoma using dental floss and clip traction. Clin Endosc. 2021;54:935–6.CrossRefPubMed
29.
Kushima R, Sekine S, Matsubara A, et al. Gastric adenocarcinoma of the fundic gland type shares common genetic and phenotypic features with pyloric gland adenoma. Pathol Int. 2013;63:318–25.CrossRefPubMed
Metadata
Title
Synchronous gastric MALT lymphoma and gastric adenocarcinoma of fundic gland type arising from a hamartomatous inverted polyp in a Helicobacter pylori naive patient
Authors
Ryo Miyamoto
Hidehiko Takigawa
Takahiro Kotachi
Hiroki Kadota
Ryo Yuge
Ryohei Hayashi
Yuji Urabe
Akira Ishikawa
Kazuhiro Sentani
Shiro Oka
Publication date
26-04-2023
Publisher
Springer Nature Singapore
Published in
Clinical Journal of Gastroenterology / Issue 4/2023
Print ISSN: 1865-7257
Electronic ISSN: 1865-7265
DOI
https://doi.org/10.1007/s12328-023-01808-8

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