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01-07-2021 | Helicobacter Pylori | Original Article

Involvement of non-Helicobacter pylori helicobacter infections in Helicobacter pylori-negative gastric MALT lymphoma pathogenesis and efficacy of eradication therapy

Authors: Hidehiko Takigawa, Ryo Yuge, Satoshi Masaki, Rina Otani, Hiroki Kadota, Toshikatsu Naito, Ryohei Hayashi, Yuji Urabe, Shiro Oka, Shinji Tanaka, Kazuaki Chayama, Yasuhiko Kitadai

Published in: Gastric Cancer | Issue 4/2021

Abstract

Background

Eradication therapy is known to be effective against Helicobacter pylori-positive gastric MALT lymphoma but predicting the efficacy of eradication therapy against Helicobacter pylori-negative gastric MALT lymphoma is difficult. Recent reports have shown that non-Helicobacter pylori helicobacter infections induce gastric MALT lymphoma, and we aimed to clarify whether non-Helicobacter pylori helicobacter infections are associated with the efficacy of eradication therapy.

Methods

We analyzed eradication therapy as a first-line treatment for 182 cases of gastric MALT lymphoma, classified according to Helicobacter pylori infection and API2-MALT1 mutation status. We also evaluated the non-Helicobacter pylori helicobacter infection status in 29 Helicobacter pylori-negative cases via PCR with DNA extracted from paraffin-embedded biopsy tissues. Finally, we analyzed the relationship between non-Helicobacter pylori helicobacter infection status and eradication therapy outcome.

Results

The API2-MALT1 mutation was observed in 13/182 patients (7.1%), none of whom were cured by eradication therapy. Helicobacter pylori-negative cases had a significantly higher non-Helicobacter pylori helicobacter infection rate than Helicobacter pylori-positive cases (16/29, 55% vs. 3/29, 10%; P < 0.05). Among the Helicobacter pylori-negative cases, non-Helicobacter pylori helicobacter-positive cases had a significantly higher complete response rate than non-Helicobacter pylori helicobacter-negative cases (12/16, 75% vs. 3/13, 23%; P < 0.05).

Conclusion

Helicobacter pylori-negative and API2-MALT1-negative gastric MALT lymphoma cases exhibited a high rate of non-Helicobacter pylori helicobacter infections, which may have contributed to the success of eradication therapy. Therefore, we recommend eradication therapy as a first-line treatment for non-Helicobacter pylori helicobacter-positive gastric MALT lymphoma.

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Title: Involvement of non-Helicobacter pylori helicobacter infections in Helicobacter pylori-negative gastric MALT lymphoma pathogenesis and efficacy of eradication therapy
Authors: Hidehiko Takigawa
Ryo Yuge
Satoshi Masaki
Rina Otani
Hiroki Kadota
Toshikatsu Naito
Ryohei Hayashi
Yuji Urabe
Shiro Oka
Shinji Tanaka
Kazuaki Chayama
Yasuhiko Kitadai
Publication date: 01-07-2021
Publisher: Springer Singapore
Keywords: Helicobacter Pylori
Mucosa Associated Lymphoid Tissue
Published in: Gastric Cancer / Issue 4/2021
Print ISSN: 1436-3291
Electronic ISSN: 1436-3305
DOI: https://doi.org/10.1007/s10120-021-01172-x

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Abstract

Background

Methods

Results

Conclusion

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