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01-03-2019 | Hepatic Encephalopathy | Original Article

Influence of proton pump inhibitors on microbiota in chronic liver disease patients

Authors: Kenta Yamamoto, Masatoshi Ishigami, Takashi Honda, Tomoaki Takeyama, Takanori Ito, Yoji Ishizu, Teiji Kuzuya, Kazuhiko Hayashi, Hidemi Goto, Yoshiki Hirooka

Published in: Hepatology International | Issue 2/2019

Abstract

Background

Current knowledge suggests that proton pump inhibitors (PPIs) are associated with an increased risk of hepatic encephalopathy (HE) and spontaneous bacterial peritonitis (SBP). These conditions and PPI use are related to gut microbiota. The aim of this study is to research the changes in gut microbiota caused by PPI in patients with chronic liver disease.

Methods

From 198 Japanese patients, 31 patients in the PPI and non-PPI groups were matched using propensity score matching (PSM) based on age, sex, and Child–Turcotte–Pugh class. We investigated the gut microbial composition of stool samples using the Illumina MiSeq sequencing platform and compared them using linear discriminant analysis effect size and phylogenetic investigation of communities by reconstruction of unobserved states.

Results

Before PSM, Child–Turcotte–Pugh score (p = 0.038), ascites (p = 0.049), encephalopathy (p = 0.023), and esophageal varices (p < 0.01) were significantly higher in the PPI group than in the non-PPI group. After PSM, six genera, consisting of Lactobacillus, Streptococcus, Selenomonas, Veillonella, Campylobacter, and Haemophilus were enriched in the PPI group. Eggerthella, Paraprevotella, Turicibacter, Dorea, Anaerotruncus, and Ruminococcus were less abundant in the PPI group. We identified five types of level 3 KEGG pathways predicted to be significantly different.

Conclusions

Part of microbial changes caused by PPI use was common to the changes by progression of liver cirrhosis. Increases in oral bacterial flora and decreases in autochthonous flora may produce the intestinal environment which tends to make the risk factor for HE or SBP.

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Title: Influence of proton pump inhibitors on microbiota in chronic liver disease patients
Authors: Kenta Yamamoto
Masatoshi Ishigami
Takashi Honda
Tomoaki Takeyama
Takanori Ito
Yoji Ishizu
Teiji Kuzuya
Kazuhiko Hayashi
Hidemi Goto
Yoshiki Hirooka
Publication date: 01-03-2019
Publisher: Springer India
Keywords: Hepatic Encephalopathy
Streptococci
Campylobacter
Proton Pump Inhibitors
Liver Cirrhosis
Respiratory Microbiota
Hepatic Encephalopathy
Published in: Hepatology International / Issue 2/2019
Print ISSN: 1936-0533
Electronic ISSN: 1936-0541
DOI: https://doi.org/10.1007/s12072-019-09932-9

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Abstract

Background

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