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Proton Pump Inhibitors 

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  1. Open Access 01-12-2024 | Proton Pump Inhibitors | OriginalPaper

    Proton pump inhibitors use is associated with a higher prevalence of kidney stones: NHANES 2007–2018

    Nephrolithiasis is a prevalent ailment that affects one out of every eleven persons in the United States [ 1 ]. Nephrolithiasis incidence has risen dramatically during the last three decades, putting an even greater financial strain on patients [ 1 …,

  2. Open Access 15-04-2024 | Gastroesophageal Reflux Disease | Online First

    Differences Between Patients with Heartburn Refractory to Vonoprazan and Those Refractory to Proton Pump Inhibitors

    Gastroesophageal reflux disease (GERD) is a condition that develops when stomach content reflux causes troublesome symptoms and/or complications [ 1 ]. GERD demonstrated an increasing incidence rate worldwide in recent years [ 2 ]. Various …

  3. 20-04-2024 | Gastrointestinal Bleeding | Online First

    Efficacy and safety of proton pump inhibitors on cardiovascular events and inflammatory factors in patients with upper gastrointestinal bleeding undergoing dual antiplatelet therapy

    Dual antiplatelet therapy (DAPT) is commonly applied after percutaneous coronary intervention (PCI) to prevent cardiovascular events (CVEs). It involves the simultaneous use of two antiplatelet drugs to reduce platelet aggregation and prevent …

  4. Open Access 01-12-2024 | Proton Pump Inhibitors | OriginalPaper

    Analysis of inappropriate prophylactic use of proton pump inhibitors during the perioperative period: an observational study

    Stress-related mucosal disease (SRMD), also known as stress ulcer, refers to the acute gastrointestinal mucosal erosion, ulceration, and other lesions occurring in the body under various stress states such as severe trauma, complex surgery, and …

  5. Open Access 01-12-2024 | Proton Pump Inhibitors | OriginalPaper

    Comparison of vonoprazan and proton pump inhibitors for the treatment of gastric endoscopic submucosal dissection-induced ulcer: an updated systematic review and meta-analysis

    Endoscopic submucosal dissection (ESD) has become the established treatment for early gastric cancer [ 1 – 3 ]. Unfortunately, ESD can cause artificial ulceration, which is occasionally linked to delayed postoperative bleeding and even perforation …

  6. 15-11-2023 | Proton Pump Inhibitors | EditorialNotes

    Risks of Proton Pump Inhibitors in Patients with Cirrhosis: Please Peruse the Indications

    The use of proton pump inhibitor (PPI) in cirrhotic patients can be associated with increased risks of long-term mortality, decompensation, hepatic encephalopathy, spontaneous bacterial peritonitis, and infection, but not with short-term …

  7. Open Access 10-11-2023 | Proton Pump Inhibitors | Review

    Cardiovascular Compatibility of Proton Pump Inhibitors: Practice Recommendations

    A critical evaluation of the current evidence regarding adverse cardiovascular effects associated with proton pump inhibitors in patients with coronary artery disease. 

  8. 15-11-2023 | Proton Pump Inhibitors | OriginalPaper

    Proton Pump Inhibitors Increases Longitudinal Risk of Mortality, Decompensation, and Infection in Cirrhosis: A Meta-Analysis

    Chronic liver disease is a major global health crisis affecting upwards of 1.5 billion people worldwide [ 1 ]. In 2017, chronic liver disease is estimated to account for 1.32 million deaths globally [ 2 ]. Liver cirrhosis in turn represents an …

  9. 09-11-2023 | Proton Pump Inhibitors | ReviewPaper

    Revisiting Proton Pump Inhibitors as Chemoprophylaxis Against the Progression of Barrett’s Esophagus

    With the rise in Barrett’s esophagus (BE), a sequelae of chronic gastroesophageal reflux disease (GERD), there has been much enthusiasm in identifying risk reduction strategies prior to the progression to carcinoma [ 1 ]. Barrett’s esophagus is a …

  10. 16-11-2023 | Pazopanib | OriginalPaper

    Potential drug interactions between pazopanib and proton pump inhibitors/potassium-competitive acid blockers in patients with soft tissue sarcoma

    Because absorption of the oral drug pazopanib depends on gastric pH, concomitant use of proton pump inhibitors (PPIs)/potassium-competitive acid blockers (P-CABs) may inhibit pazopanib absorption by elevating the gastric pH. This study …

  11. Open Access 20-12-2023 | Oral Anticoagulant | OriginalPaper

    Do Proton Pump Inhibitors Reduce Upper Gastrointestinal Bleeding in Older Patients with Atrial Fibrillation Treated with Oral Anticoagulants? A Nationwide Cohort Study in France

    Proton pump inhibitors (PPIs, such as pantoprazole, esomeprazole, omeprazole, lansoprazole, and rabeprazole) are drugs indicated for the treatment and prevention of peptic ulcer and gastroesophageal reflux diseases [ 1 ]. The efficacy and safety of …

  12. 26-09-2023 | Eosinophilic Esophagitis | OriginalPaper

    Proton pump inhibitors in eosinophilic esophagitis (EoE) related to oral immunotherapy: is it as effective as in other EoE?

    Oral immunotherapy (OIT) may induce eosinophilic esophagitis (EoE). Proton pump inhibitors (PPIs) are an effective treatment for EoE. However, the effect of PPI treatment is not well established in patients with EoE induced by OIT. Our primary aim …

  13. Open Access 01-12-2023 | NSCLC | OriginalPaper

    Clinical impact of tetracyclines and/or proton pump inhibitors on the efficacy of epidermal growth factor receptor inhibitors in non-small cell lung cancer: a retrospective cohort study

    Lung cancer is the leading cause of cancer-related death in men and women worldwide. This disease was expected to result in the deaths of nearly 132,000 individuals in the USA in 2021 [ 1 ]. Almost 85% of lung cancers are non-small cell lung cancer …

  14. 01-05-2023 | Nausea | News

    Sucralfate/unspecified proton pump inhibitors

    Lack of efficacy: 2 case reports
  15. 07-10-2023 | Warfarin | ReviewPaper

    Effect of aspirin, warfarin, and proton-pump inhibitors on performance of fecal immunochemical test in colorectal cancer screening: a systematic review and meta-analysis

    This study aims to investigate the impact of antithrombotic agents and proton-pump inhibitors (PPIs) on fecal immunochemical test (FIT). PubMed, EMBASE, Web of Science, Cochrane Central, and Google Scholar were searched from inception until …

  16. Open Access 01-12-2023 | Chronic Kidney Disease | OriginalPaper

    Kidney function decline associated with proton pump inhibitors: results from the ELSA-Brasil cohort

    Proton pump inhibitors (PPIs) are drugs used for gastric disorders. Because of their low toxicity, they are overprescribed and not always used rationally [ 1 , 2 ]. Although PPIs are safe, observational studies suggest that PPI use is associated …

  17. 07-09-2023 | Metformin | OriginalPaper

    Use of concomitant proton pump inhibitors, statins or metformin in patients treated with pembrolizumab for metastatic urothelial carcinoma: data from the ARON-2 retrospective study

    In recent years, the introduction of immune checkpoint inhibitors (ICIs) targeting the programmed cell death protein-1 (PD-1)/ligand-1 (PD-L1) for the treatment of advanced or metastatic urothelial carcinoma (mUC) has improved outcomes and quality …

  18. 18-06-2022 | Famotidine | ReviewPaper

    Antacid Therapy in Coronary Artery Disease and Heart Failure: Proton Pump Inhibitors vs. H2 Receptor Blockers

    Dual antiplatelet therapy (DAPT, aspirin plus a P2Y 12 inhibitor) is utilized to improve cardiovascular outcomes in patients with acute coronary syndrome (ACS) and several subgroups of patients with chronic coronary artery disease (CAD) syndromes [ …1

  19. 01-04-2023 | Chronic Kidney Disease | ReviewPaper

    Prescribe proton pump inhibitors with care and be aware of the signs of nephrotoxicity

    Several studies have reported an association between proton pump inhibitor (PPI) use and incidences of adverse kidney events, including acute interstitial nephritis and chronic kidney disease, which may progress to kidney failure. This article …

  20. 12-09-2023 | Proton Pump Inhibitors | OriginalPaper

    Guidelines on optimizing the use of proton pump inhibitors: PPI stewardship

    Proton pump inhibitors (PPIs) have been available for over three decades and are among the most commonly prescribed medications. They are effective in treating a variety of gastric acid-related disorders. They are freely available and based on …

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