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Immunologic Research
Published in: Immunologic Research 3/2017

01-06-2017 | Original Article

The improvement of M1 polarization in macrophages by glycopeptide derived from Ganoderma lucidum

Authors: Li-Xin Sun, Zhi-Bin Lin, Jie Lu, Wei-Dong Li, Yan-Dong Niu, Yu Sun, Chen-Yang Hu, Guo-Qiang Zhang, Xin-Suo Duan

Published in: Immunologic Research | Issue 3/2017

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Abstract

Ganoderma lucidum (Fr.) Karst (Ganodermataceae) is a medicinal mushroom that has been extensively used in China for centuries to promote longevity and improve vigor without significant adverse effects. There is continuous interest in the bioactive properties of G. lucidum in view of its newly developed popularity in other regions besides Asia, such as Europe. Glycopeptide derived from G. lucidum (Gl-PS) is one of the main effective components isolated from this mushroom. The Gl-PS has been demonstrated pleiotropic with many bioactivities including immunomodulatory and antitumor effects. Macrophages are important cells involved in innate and adaptive immunity. Classically activated macrophages (M1) and alternatively activated macrophages (M2), with their different roles, display distinct cytokine profiles: M1 preferentially produces TNF-α, IL-6, and IL-12; conversely, M2 generates more IL-10 and arginase. Gl-PS might have the potential to promote macrophage M1 polarization by lipopolysaccharide (LPS). In this study, LPS was used to induce the M1 polarization. It was shown that the level of the TNF-α, IL-6, and IL-12 were increased and the IL-10 and arginase I were decreased in the polarized M1 macrophages after application of Gl-PS compared to the control. The results indicated the potential of Gl-PS to promote M1 polarization vs M2, with the health beneficial understanding of the bioactivities of Gl-PS.
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Metadata
Title
The improvement of M1 polarization in macrophages by glycopeptide derived from Ganoderma lucidum
Authors
Li-Xin Sun
Zhi-Bin Lin
Jie Lu
Wei-Dong Li
Yan-Dong Niu
Yu Sun
Chen-Yang Hu
Guo-Qiang Zhang
Xin-Suo Duan
Publication date
01-06-2017
Publisher
Springer US
Published in
Immunologic Research / Issue 3/2017
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-017-8893-3

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