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Immunologic Research
Published in: Immunologic Research 1-3/2015

01-12-2015 | NEUROIMMUNOLOGY

Neural circuitry and immunity

Authors: Valentin A. Pavlov, Kevin J. Tracey

Published in: Immunologic Research | Issue 1-3/2015

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Abstract

Research during the last decade has significantly advanced our understanding of the molecular mechanisms at the interface between the nervous system and the immune system. Insight into bidirectional neuro-immune communication has characterized the nervous system as an important partner of the immune system in the regulation of inflammation. Neuronal pathways, including the vagus nerve-based inflammatory reflex, are physiological regulators of immune function and inflammation. In parallel, neuronal function is altered in conditions characterized by immune dysregulation and inflammation. Here, we review these regulatory mechanisms and describe the neural circuitry modulating immunity. Understanding these mechanisms reveals possibilities to use targeted neuromodulation as a therapeutic approach for inflammatory and autoimmune disorders. These findings and current clinical exploration of neuromodulation in the treatment of inflammatory diseases define the emerging field of Bioelectronic Medicine.
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Metadata
Title
Neural circuitry and immunity
Authors
Valentin A. Pavlov
Kevin J. Tracey
Publication date
01-12-2015
Publisher
Springer US
Published in
Immunologic Research / Issue 1-3/2015
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-015-8718-1

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