Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Current Pain and Headache Reports
Published in: Current Pain and Headache Reports 6/2015

01-06-2015 | Psychological and Behavioral Aspects of Headache and Pain (D Buse, Section Editor)

Improving Medication Adherence in Migraine Treatment

Authors: Elizabeth K. Seng, Jeanetta A. Rains, Robert A. Nicholson, Richard B. Lipton

Published in: Current Pain and Headache Reports | Issue 6/2015

Login to get access

Abstract

Medication adherence is integral to successful treatment of migraine and other headache. The existing literature examining medication adherence in migraine is small, and the methodologies used to assess adherence are limited. However, these studies broadly suggest poor adherence to both acute and preventive migraine medications, with studies using more objective monitoring reporting lower adherence rates. Methods for improving medication adherence are described, including organizational strategies, provider-monitoring and self-monitoring of adherence, regimen strategies, patient education, self-management skills training (e.g., stimulus control, behavioral contracts), and cognitive–behavioral therapy techniques. The article concludes by discussing the future of research regarding adherence to medications for migraine and other headaches.
Literature
1.
Katic BJ, Krause SJ, Tepper SJ, Hu HX, Bigal ME. Adherence to acute migraine medication: what does it mean, why does it matter? Headache. 2010;50(1):117–29.PubMedCrossRef
2.
Reed ML, Fanning KM, Serrano D, Buse DC, Lipton RB. Persistent frequent nausea is associated with progression to chronic migraine: AMPP study results. Headache. 2015;55(1):76–87.
3.
Lipton RB, Bigal ME, Diamond M, Freitag F, Reed ML, Stewart WF. Migraine prevalence, disease burden, and the need for preventive therapy. Neurology. 2007;68(5):343–9.PubMedCrossRef
4.
Bigal ME, Serrano D, Buse D, Scher A, Stewart WF, Lipton RB. Acute migraine medications and evolution from episodic to chronic migraine: a longitudinal population-based study. Headache. 2008;48(8):1157–68.PubMedCrossRef
5.•
Lipton RB, Fanning KM, Serrano D, Reed ML, Cady R, Buse DC. Ineffective acute treatment of episodic migraine is associated with new-onset chronic migraine. Neurology. 2015;84(7):688–95. This large epidemiologic study provides evidence that patient perception of medication efficacy is associated with migraine chronification.
6.
Silberstein SD, Holland S, Freitag F, Dodick DW, Argoff C, Ashman E. Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology. 2012;78(17):1337–45.PubMedCentralPubMedCrossRef
7.
Holland S, Silberstein SD, Freitag F, Dodick DW, Argoff C, Ashman E. Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology. 2012;78(17):1346–53.PubMedCentralPubMedCrossRef
8.
Rains JC, Lipchik GL, Penzien DB. Behavioral facilitation of medical treatment for headache—part I: review of headache treatment compliance. Headache. 2006;46(9):1387–94.PubMedCrossRef
9.•
Ramsey RR, Ryan JL, Hershey AD, Powers SW, Aylward BS, Hommel KA. Treatment adherence in patients with headache: a systematic review. Headache J Head Face Pain. 2014;54(5):795–816. This is a thorough review of the treatment adherence literature across patients with headache, which highlights the paucity of research on acute medication adherence, adherence with lifestyle recommendations, and adherence with children and adolescents.CrossRef
10.
Nicholson RA, Smith TR. Likelihood of patients adhering to acute medication during migraine attacks. Submitted for presentation at the annual scientific meeting of the American Headache Society, Washington, DC.
11.
Nicholson RA, Chibnall JT, Ng-Mak D, Banks JW, Smith TR. Why wait? Reasons that patients delay taking a triptan during individual migraine attacks. Headache. 2011;51(S1):S6–7.
12.
Sattler EL, Lee JS, Perri 3rd M. Medication (re)fill adherence measures derived from pharmacy claims data in older Americans: a review of the literature. Drugs Aging. 2013;30(6):383–99.PubMedCrossRef
13.
14.
Hepp Z, Dodick DW, Varon SF, Gillard P, Hansen RN, Devine EB. Adherence to oral migraine-preventive medications among patients with chronic migraine. Cephalalgia. 2014;27:2014.
15.
Hepp Z, Bloudek LM, Varon SF. Systematic review of migraine prophylaxis adherence and persistence. J Manag Care Pharm. 2014;20(1):22–33.PubMed
16.
Mulleners WM, Whitmarsh TE, Steiner TJ. Noncompliance may render migraine prophylaxis useless, but once-daily regimens are better. Cephalalgia. 1998;18(1):52–6.PubMedCrossRef
17.
Steiner TJ, Catarci T, Hering R, Whitmarsh T, Couturier EG. If migraine prophylaxis does not work, think about compliance. Cephalalgia. 1994;14(6):463–4.PubMedCrossRef
18.
Matchar D, Harpole L, Samsa G, Jurgelski A, Lipton R, Silberstein S, et al. The headache management trial: a randomized study of coordinated care. Headache. 2008;48(9):1294–310.PubMedCrossRef
19.
Oberje EJ, de Kinderen RJ, Evers SM, van Woerkum CM, de Bruin M. Cost effectiveness of medication adherence-enhancing interventions: a systematic review of trial-based economic evaluations. Pharmacoeconomics. 2013;31(12):1155–68.PubMedCrossRef
20.
Messali AJ, Yang M, Gillard P, Tsai K, Tepper SJ, Bloudek LM, et al. Treatment persistence and switching in triptan users: a systematic literature review. Headache. 2014;54(7):1120–30.PubMedCrossRef
21.
Blumenfeld AM, Bloudek LM, Becker WJ, Buse DC, Varon SF, Maglinte GA, et al. Patterns of use and reasons for discontinuation of prophylactic medications for episodic migraine and chronic migraine: results from the second international burden of migraine study (IBMS-II). Headache. 2013;53(4):644–55.PubMedCrossRef
22.•
Seng EK, Holroyd KA. Optimal use of acute headache medication: a qualitative examination of behaviors and barriers to their performance. Headache. 2013;53(9):1438–50. This qualitative study describes patient and provider perceptions about the medication-taking behaviors necessary for optimal use of acute headache medications, highlighting the barriers patients experience in their daily lives as they attempt to adhere with acute headache medication.PubMed
23.
Gaul C, van Doorn C, Webering N, Dlugaj M, Katsarava Z, Diener HC, et al. Clinical outcome of a headache-specific multidisciplinary treatment program and adherence to treatment recommendations in a tertiary headache center: an observational study. J Headache Pain. 2011;12(4):475–83.PubMedCentralPubMedCrossRef
24.
25.
Haynes RB, Yao X, Degani A, Kripalani S, Garg A, McDonald HP. Interventions to enhance medication adherence. Cochrane Database Syst Rev. 2005;4, CD000011.PubMed
26.
Holroyd K, Cottrell C, O’Donnell F, Cordingley G, Carson B, Himiwan L. Effect of preventive (B blocker) treatment, behavioral migraine management or their combination on outcomes of optimized acute therapy in frequent migraine: randomized trial. BMJ. 2010;341:c4871.
27.
Rains J, Penzien D, Lipchik G. Behavioral facilitation of medical treatment for headache part II: theoretical models and behavioral strategies for improving adherence. Headache. 2006;46(9):1395–403.PubMedCrossRef
28.
Spierings EL, Miree LF. Non-compliance with follow-up and improvement after treatment at a headache center. Headache. 1993;33(4):205–9.PubMedCrossRef
29.
Garber MC, Nau DP, Erickson SR, Aikens JE, Lawrence JB. The concordance of self-report with other measures of medication adherence: a summary of the literature. Med Care. 2004;42(7):649–52.PubMedCrossRef
30.•
Wells RE, Markowitz SY, Baron EP, Hentz JG, Kalidas K, Mathew PG, et al. Identifying the factors underlying discontinuation of triptans. Headache. 2014;54(2):278–89. This study describes correlates of triptan discontinuation, highlighting the roles of treatment efficacy, migraine-related disability, psychiatric symptoms and triptan-related beliefs.PubMedCentralPubMedCrossRef
31.
Hahn S, Lipton R, Sheftell F. Healthcare provider-patient communication and migraine assessment: results of the American Migraine Communication Study (AMCS) phase II. Curr Med Res Opin. 2006;24:1711–8.CrossRef
32.
Saper JR, Lake 3rd AE. Borderline personality disorder and the chronic headache patient: review and management recommendations. Headache. 2002;42(7):663–74.PubMedCrossRef
33.
Lash SJ, Stephens RS, Burden JL, Grambow SC, DeMarce JM, Jones ME, et al. Contracting, prompting, and reinforcing substance use disorder continuing care: a randomized clinical trial. Psychol Addict Behav J Soc Psychol Addict Behav. 2007;21(3):387–97.CrossRef
34.
Bandura A. Self-efficacy: the exercise of control. New York: W.H. Freeman; 1997.
35.
Seng EK, Holroyd KA. Dynamics of changes in self-efficacy and locus of control expectancies in the behavioral and drug treatment of severe migraine. Ann Behav Med. 2010;40(3):235–47.PubMedCrossRef
36.
Beck AT. Cognitive therapy and the emotional disorders. New York: International Universities Press; 1976.
Metadata
Title
Improving Medication Adherence in Migraine Treatment
Authors
Elizabeth K. Seng
Jeanetta A. Rains
Robert A. Nicholson
Richard B. Lipton
Publication date
01-06-2015
Publisher
Springer US
Published in
Current Pain and Headache Reports / Issue 6/2015
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-015-0498-8

Other articles of this Issue 6/2015

Current Pain and Headache Reports 6/2015 Go to the issue

Imaging (L Mechtler, Section Editor)

Trigeminal Neuralgia and Facial Pain Imaging

Imaging (L Mechtler, Section Editor)

Neuroimaging of Headaches Associated with Vascular Disorders

Imaging (L Mechtler, Section Editor)

Neuroimaging and the Clinical Manifestations of Chiari Malformation Type I (CMI)

Uncommon and/or Unusual Headaches and Syndromes (J Ailani, Section Editor)

Visual Snow—Persistent Positive Visual Phenomenon Distinct from Migraine Aura

Trigeminal Autonomic Cephalalgias (B Vargas, Section Editor)

Do Trigeminal Autonomic Cephalalgias Represent Primary Diagnoses or Points on a Continuum?

Childhood and Adolescent Headache (S Evers, Section Editor)

From Ophthalmoplegic Migraine to Cranial Neuropathy