Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Current Pain and Headache Reports
Published in: Current Pain and Headache Reports 6/2015

01-06-2015 | Childhood and Adolescent Headache (S Evers, Section Editor)

From Ophthalmoplegic Migraine to Cranial Neuropathy

Authors: Stefanie Förderreuther, Ruth Ruscheweyh

Published in: Current Pain and Headache Reports | Issue 6/2015

Login to get access

Abstract

Ophthalmoplegic migraine (OM)/recurrent painful ophthalmoplegic neuropathy (RPON) is a rare disease consisting of recurrent unilateral headache accompanied or followed by ipsilateral ophthalmoplegia. Because MRI findings suggest neuropathy and the relationship to typical migraine remains unclear, the disease has been renamed from “ophthalmoplegic migraine” to “recurrent painful oculomotor neuropathy” in the third edition of the International Classification of Headache Disorders (ICHD). However, it remains a fact that most cases of OM/RPON described in the literature have a history of migraine and that the headache during OM/RPON often has migrainous features. A more detailed clinical description of the headache during OM/RPON and additional results from imaging and possibly histology will be needed to better understand the pathophysiology of the disease and its relationship to typical migraine.
Literature
1.
Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia: Int J Headache. 1988;8 Suppl 7:1–96.
2.
Charcot JM. Sur un cas de migraine ophthalmoplegique. Progr Med. 1890;1:83–6.
3.
Lance JW, Zagami AS. Ophthalmoplegic migraine: a recurrent demyelinating neuropathy? Cephalalgia: Int J Headache. 2001;21(2):84–9.CrossRef
4.••
Gelfand AA, Gelfand JM, Prabakhar P, Goadsby PJ. Ophthalmoplegic "migraine" or recurrent ophthalmoplegic cranial neuropathy: new cases and a systematic review. J Child Neurol. 2012;27(6):759–66. Is an excellent review on the clinical findings of OM/RPON with a thorough discussion of the pathophysiological mechanisms in favour of neuropathy.
5.
Lal V, Sahota P, Singh P, Gupta A, Prabhakar S. Ophthalmoplegia with migraine in adults: is it ophthalmoplegic migraine? Headache. 2009;49(6):838–50.PubMedCrossRef
6.
Margari L, Legrottaglie AR, Craig F, Petruzzelli MG, Procoli U, Dicuonzo F. Ophthalmoplegic migraine: migraine or oculomotor neuropathy? Cephalalgia: Int J Headache. 2012;32(16):1208–15.CrossRef
7.
Giraud P, Valade D, Lanteri-Minet M, Donnet A, Geraud G, Guegan-Massardier E, et al. Is migraine with cranial nerve palsy an ophthalmoplegic migraine? J Headache Pain. 2007;8(2):119–22.PubMedCentralPubMedCrossRef
8.
Carlow TJ. Oculomotor ophthalmoplegic migraine: is it really migraine? J Neuro-Ophthalmology: Off J N Am Neuro-Ophthalmology Soc. 2002;22(3):215–21.CrossRef
9.
McMillan HJ, Keene DL, Jacob P, Humphreys P. Ophthalmoplegic migraine: inflammatory neuropathy with secondary migraine? Can J Neurol Sci J Can Sci Neurol. 2007;34(3):349–55.CrossRef
10.
Pareja JA, Churruca J, de la Casa FB, de Silanes CL, Sanchez C, Barriga FJ. Ophthalmoplegic migraine. Two patients with an absolute response to indomethacin. Cephalalgia: Int J Headache. 2010;30(6):757–60.
11.
Lane R, Davies P. Ophthalmoplegic migraine: the case for reclassification. Cephalalgia: Int J Headache. 2010;30(6):655–61.
12.
Lavin PJ, Aulino JM, Uskavitch D. "Ophthalmoplegic migraine" with reversible MRI enhancement of the cisternal sixth cranial nerve. J Neuro-Ophthalmology: Off J N Am Neuro-Ophthalmology Soc. 2009;29(2):151–3.CrossRef
13.
Maggioni F, Briani C, Margoni M, Zanchin G. Ophthalmoplegic migraine: could electroencephalogram still be a useful tool to better understand the pathogenetic mechanism? Cephalalgia: Int J Headache. 2012;32(16):1227–9.CrossRef
14.
Manzouri B, Sainani A, Plant G, Lee J, Sloper J. The aetiology and management of long-lasting sixth nerve palsy in ophthalmoplegic migraine. Cephalalgia: Int J Headache. 2007;27(3):275–8.CrossRef
15.
Miglio L, Feraco P, Tani G, Ambrosetto P. Computed tomography and magnetic resonance imaging findings in ophthalmoplegic migraine. Pediatr Neurol. 2010;42(6):434–6.PubMedCrossRef
16.
van der Dussen DH, Bloem BR, Liauw L, Ferrari MD. Ophthalmoplegic migraine: migrainous or inflammatory? Cephalalgia: Int J Headache. 2004;24(4):312–5.CrossRef
17.
Linn J, Schwarz F, Reinisch V, Straube A. Ophthalmoplegic migraine with paresis of the sixth nerve: a neurovascular compression syndrome? Cephalalgia: Int J Headache. 2008;28(6):667–70.CrossRef
18.
Mucchiut M, Valentinis L, Provenzano A, Cutuli D, Bergonzi P. Adult-onset ophthalmoplegic migraine with recurrent sixth nerve palsy: a case report. Headache. 2006;46(10):1589–90.PubMedCrossRef
19.
O’Halloran HS, Lee WB, Baker RS, Pearson PA. Ophthalmoplegic migraine with unusual features. Headache. 1999;39(9):670–3.PubMedCrossRef
20.
Wang Y, Wang XH, Tian MM, Xie CJ, Liu Y, Pan QQ, et al. Ophthalmoplegia starting with a headache circumscribed in a line-shaped area: a subtype of ophthalmoplegic migraine? J Headache Pain. 2014;15:19.PubMedCentralPubMedCrossRef
21.
Crevits L, Verschelde H, Casselman J. Ophthalmoplegic migraine: an unresolved problem. Cephalalgia: Int J Headache. 2006;26(10):1255–9.CrossRef
22.
23.
Prats JM, Mateos B, Garaizar C. Resolution of MRI abnormalities of the oculomotor nerve in childhood ophthalmoplegic migraine. Cephalalgia: Int J Headache. 1999;19(7):655–9.CrossRef
24.
Sobreira I, Sousa C, Raposo A, Fagundes F, Dias AI. Ophthalmoplegic migraine with persistent dilated pupil. J Child Neurol. 2013;28(2):275–6.PubMedCrossRef
25.
Ostergaard JR, Moller HU, Christensen T. Recurrent ophthalmoplegia in childhood: diagnostic and etiologic considerations. Cephalalgia: Int J Headache. 1996;16(4):276–9.CrossRef
26.
Ramelli GP, Vella S, Lovblad K, Remonda L, Vassella F. Swelling of the third nerve in a child with transient oculomotor paresis: a possible cause of ophthalmoplegic migraine. Neuropediatrics. 2000;31(3):145–7.PubMedCrossRef
27.
Wong V, Wong WC. Enhancement of oculomotor nerve: a diagnostic criterion for ophthalmoplegic migraine? Pediatr Neurol. 1997;17(1):70–3.PubMedCrossRef
28.•
Hung CH, Chang KH, Chu CC, Liao MF, Chang HS, Lyu RK, et al. Painful ophthalmoplegia with normal cranial imaging. BMC Neurol. 2014;14:7. This article gives a good overview on the clinical spectrum of “painful ophthalmoplegia”.
29.
Walsh JP, O’Doherty DS. A possible explanation of the mechanism of ophthalmoplegic migraine. Neurology. 1960;10:1079–84.PubMedCrossRef
30.
Vijayan N. Ophthalmoplegic migraine: ischemic or compressive neuropathy? Headache. 1980;20(6):300–4.PubMedCrossRef
31.
Mark AS, Casselman J, Brown D, Sanchez J, Kolsky M, Larsen 3rd TC, et al. Ophthalmoplegic migraine: reversible enhancement and thickening of the cisternal segment of the oculomotor nerve on contrast-enhanced MR images. AJNR Am J Neuroradiol. 1998;19(10):1887–91.PubMed
32.
Bharucha DX, Campbell TB, Valencia I, Hardison HH, Kothare SV. MRI findings in pediatric ophthalmoplegic migraine: a case report and literature review. Pediatr Neurol. 2007;37(1):59–63.PubMedCrossRef
33.
Headache Classification Subcommittee of the International Headache S. The international classification of headache disorders: 2nd edition. Cephalalgia: Int J Headach. 2004;24 Suppl 1:9–160.
34.
Headache Classification Committee of the International Headache S. The international classification of headache disorders, 3rd edition (beta version). Cephalalgia: Int J Headach. 2013;33(9):629–808.CrossRef
35.
36.
37.
Chang-Godinich A, Lee AG, Brazis PW, Liesegang TJ, Jones DB. Complete ophthalmoplegia after zoster ophthalmicus. J Neuro-Ophthalmology: Off J N Am Neuro-Ophthalmology Soc. 1997;17(4):262–5.CrossRef
38.
Hakim W, Sherman R, Rezk T, Pannu K. An acute case of herpes zoster ophthalmicus with ophthalmoplegia. Case Rep Ophthalmol Med. 2012;2012:953910.PubMedCentralPubMed
39.••
Ambrosetto P, Nicolini F, Zoli M, Cirillo L, Feraco P, Bacci A. Ophthalmoplegic migraine: from questions to answers. Cephalalgia: Int J Headach. 2014;34(11):914–9. This paper summarizes the arguments in favour of a migrainous pathophysiology.
40.
Fanciullacci M, Alessandri M, Figini M, Geppetti P, Michelacci S. Increase in plasma calcitonin gene-related peptide from the extracerebral circulation during nitroglycerin-induced cluster headache attack. Pain. 1995;60(2):119–23.PubMedCrossRef
41.
Goadsby PJ, Edvinsson L. Human in vivo evidence for trigeminovascular activation in cluster headache. Neuropeptide changes and effects of acute attacks therapies. Brain: J Neurol. 1994;117(Pt 3):427–34.CrossRef
42.
Cernuda-Morollon E, Larrosa D, Ramon C, Vega J, Martinez-Camblor P, Pascual J. Interictal increase of CGRP levels in peripheral blood as a biomarker for chronic migraine. Neurology. 2013;81(14):1191–6.PubMedCrossRef
43.
Lanzino G, Andreoli A, Tognetti F, Limoni P, Calbucci F, Bortolami R, et al. Orbital pain and unruptured carotid-posterior communicating artery aneurysms: the role of sensory fibers of the third cranial nerve. Acta Neurochir. 1993;120(1–2):7–11.PubMedCrossRef
44.
Reilly GS, Shin RK. Teaching NeuroImages: herpes zoster ophthalmicus-related oculomotor palsy accompanied by Hutchinson sign. Neurology. 2010;74(15):e65.PubMedCrossRef
45.
Costello F, Lee AG, Afifi AK, Kelkar P, Kardon RH, White M. Childhood-onset chronic inflammatory demyelinating polyradiculoneuropathy with cranial nerve involvement. J Child Neurol. 2002;17(11):819–23.PubMedCrossRef
46.
Pieh C, Rossillion B, Heritier-Barras AC, Chofflon M, Landis T, Safran AB. Isolated unilateral adduction deficit and ptosis as the presenting features of chronic inflammatory demyelinating polyradiculoneuropathy. J Neuro-Ophthalmology: Off J N Am Neuro-Ophthalmology Soc. 2002;22(2):92–4.CrossRef
47.
Hsieh DT, Singh R, Zecavati N, Emmanuel B. Teaching video NeuroImage: near complete ophthalmoplegia in GQ1b antibody-positive Miller Fisher: video and MRI correlation. Neurology. 2008;71(14):e31.PubMedCrossRef
48.
Zuccoli G, Panigrahy A, Bailey A, Fitz C. Redefining the Guillain-Barre spectrum in children: neuroimaging findings of cranial nerve involvement. AJNR Am J Neuroradiol. 2011;32(4):639–42.PubMedCrossRef
49.
Lee AG. Oculomotor ophthalmoplegic migraine: what really causes it? J Neuro-Ophthalmology: Off J N Am Neuro-Ophthalmology Soc. 2003;23(3):240. author reply -1.CrossRef
Metadata
Title
From Ophthalmoplegic Migraine to Cranial Neuropathy
Authors
Stefanie Förderreuther
Ruth Ruscheweyh
Publication date
01-06-2015
Publisher
Springer US
Published in
Current Pain and Headache Reports / Issue 6/2015
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-015-0492-1

Other articles of this Issue 6/2015

Current Pain and Headache Reports 6/2015 Go to the issue

Psychological and Behavioral Aspects of Headache and Pain (D Buse, Section Editor)

Improving Medication Adherence in Migraine Treatment

Trigeminal Autonomic Cephalalgias (B Vargas, Section Editor)

Do Trigeminal Autonomic Cephalalgias Represent Primary Diagnoses or Points on a Continuum?

Imaging (L Mechtler, Section Editor)

Recent Neuroimaging Advances in the Study of Primary Headaches

Imaging (L Mechtler, Section Editor)

Neuroimaging and the Clinical Manifestations of Chiari Malformation Type I (CMI)

Neuromodulation (M Gofeld, Section Editor)

Managing Intrathecal Drug Delivery (ITDD) in Cancer Patients

Uncommon and/or Unusual Headaches and Syndromes (J Ailani, Section Editor)

Visual Snow—Persistent Positive Visual Phenomenon Distinct from Migraine Aura