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Current Osteoporosis Reports

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01-06-2019 | Fracture Healing | Skeletal Development (R Marcucio and J Feng, Section Editors)

A Second Career for Chondrocytes—Transformation into Osteoblasts

Authors: Lena Ingeborg Wolff, Christine Hartmann

Published in: Current Osteoporosis Reports | Issue 3/2019

Abstract

Purpose of Review

The goal of the review is to summarize the current knowledge on the process of chondrocyte-to-osteoblast transdifferentiation during endochondral bone formation and its potential implications in fracture healing and disease.

Recent Findings

Lineage tracing experiments confirmed the transdifferentiation of chondrocytes into osteoblasts. More recent studies lead to the discovery of molecules involved in this process, as well as to the hypothesis that these cells may re-enter a stem cell-like phase prior to their osteoblastic differentiation.

Summary

This review recapitulates the current knowledge regarding chondrocyte transdifferentiating into osteoblasts, the developmental and postnatal events where transdifferentiation appears to be relevant, and the molecules implicated in this process.

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Title: A Second Career for Chondrocytes—Transformation into Osteoblasts
Authors: Lena Ingeborg Wolff
Christine Hartmann
Publication date: 01-06-2019
Publisher: Springer US
Keyword: Fracture Healing
Published in: Current Osteoporosis Reports / Issue 3/2019
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-019-00511-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A Second Career for Chondrocytes—Transformation into Osteoblasts

Abstract

Purpose of Review

Recent Findings

Summary

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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