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Current Neurology and Neuroscience Reports

Published in:

01-05-2010

Cortical Spreading Depression and Migraine

Authors: Katharina Eikermann-Haerter, Cenk Ayata

Published in: Current Neurology and Neuroscience Reports | Issue 3/2010

Abstract

Cortical spreading depression, a slowly propagating wave of transient neuronal and glial depolarization, is widely accepted as the electrophysiologic substrate of migraine aura and a trigger for headache. Recent clinical and experimental evidence reinforces the putative role of cortical spreading depression in migraine pathophysiology. Imaging studies in migraineurs demonstrated hemodynamic changes consistent with cortical spreading depression during aura, whereas recent animal studies helped unravel pathophysiologic aspects such as the triggering mechanisms, genetic and hormonal modulation, and potential therapeutic targets. Here, we provide an overview of recent advances in our understanding of migraine pathophysiology and treatment.

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Title: Cortical Spreading Depression and Migraine
Authors: Katharina Eikermann-Haerter
Cenk Ayata
Publication date: 01-05-2010
Publisher: Current Science Inc.
Published in: Current Neurology and Neuroscience Reports / Issue 3/2010
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI: https://doi.org/10.1007/s11910-010-0099-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Cortical Spreading Depression and Migraine

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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