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Current Neurology and Neuroscience Reports
Published in: Current Neurology and Neuroscience Reports 3/2010

01-05-2010 | Clinical Trial Report

The Role of Temozolomide in Elderly Patients with Glioblastoma

Author: Lauren E. Abrey

Published in: Current Neurology and Neuroscience Reports | Issue 3/2010

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Excerpt

Brandes AA, Francheschi E, Tosoni A, et al.: Temozolomide concomitant and adjuvant to radiotherapy in elderly patients with glioblastoma: correlation with MGMT promoter methylation status. Cancer 2009, 115:3512–3518. …
Literature
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Stupp R, Mason WP, van den Bent MJ, et al.: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005, 352:987–996.CrossRefPubMed
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Keime-Guibert F, Chinot O, Taillandier L, et al.: Radiotherapy for glioblastoma in the elderly. N Engl J Med 2007, 356:1527–1535.CrossRefPubMed
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Hegi ME, Diserens AC, Gorlia T, et al.: MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 2005, 352:997–1003.CrossRefPubMed
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Brandes AA, Vastola F, Basso U, et al.: A prospective study on glioblastoma in the elderly. Cancer 2003, 97:657–662.CrossRefPubMed
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Combs SE, Wagner J, Bischof M, et al.: Postoperative treatment of primary glioblastoma multiforme with radiation and concomitant temozolomide in elderly patients. Int J Radiat Oncol Biol Phys 2008, 70:987–992.PubMed
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Minniti G, De Sanctis V, Muni R, et al.: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma in elderly patients. J Neurooncol 2008, 88:97–103.CrossRefPubMed
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Sijben AE, McIntyre JB, Roldan GB, et al.: Toxicity from chemoradiotherapy in older patients with glioblastoma multiforme. J Neurooncol 2008, 89:97–103.CrossRefPubMed
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Batchelor TT, Betensky RA, Esposito JM, et al.: Age-dependent prognostic effects of genetic alterations in glioblastoma. Clin Cancer Res 2004, 10:228–233.CrossRefPubMed
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Jaeckle KA, Eyre HJ, Townsend JJ, et al.: Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bis-chloroethylnitrosourea: a Southwest Oncology Group study. J Clin Oncol 1998, 16:3310–3315.PubMed
Metadata
Title
The Role of Temozolomide in Elderly Patients with Glioblastoma
Author
Lauren E. Abrey
Publication date
01-05-2010
Publisher
Current Science Inc.
Published in
Current Neurology and Neuroscience Reports / Issue 3/2010
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-010-0106-6

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