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Current Hypertension Reports

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01-02-2018 | Hypertension and the Brain (R Wainford, Section Editor)

Vasopressin, Central Autonomic Control and Blood Pressure Regulation

Authors: Maja Lozić, Olivera Šarenac, David Murphy, Nina Japundžić-Žigon

Published in: Current Hypertension Reports | Issue 2/2018

Abstract

Purpose of Review

We present recent advances in understanding of the role of vasopressin as a neurotransmitter in autonomic nervous system control of the circulation, emphasizing hypothalamic mechanisms in the paraventricular nucleus (PVN) involved in controlling sympathetic outflow toward the cardiovascular system.

Recent Findings

Suggest that somato-dendritically released vasopressin modulates the activity of magnocellular neurons in the PVN and SON, their discharge pattern and systemic release. Advances have been made in uncovering autocrine and paracrine mechanisms controlling presympathetic neuron activity, involving intranuclear receptors, co-released neuroactive substances and glia.

Summary

It is now obvious that intranuclear release of vasopressin and the co-release of neuroactive substances in the PVN, as well as the level of expression of vasopressin receptors, modulate sympathetic outflow to the cardiovascular system and determine vulnerability to stress. Further research involving patho-physiological models is needed to validate these targets and foster the development of more efficient treatment.

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Title: Vasopressin, Central Autonomic Control and Blood Pressure Regulation
Authors: Maja Lozić
Olivera Šarenac
David Murphy
Nina Japundžić-Žigon
Publication date: 01-02-2018
Publisher: Springer US
Published in: Current Hypertension Reports / Issue 2/2018
Print ISSN: 1522-6417
Electronic ISSN: 1534-3111
DOI: https://doi.org/10.1007/s11906-018-0811-0

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Abstract

Purpose of Review

Recent Findings

Summary

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