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Current Diabetes Reports

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01-09-2018 | Therapies and New Technologies in the Treatment of Diabetes (M Pietropaolo, Section Editor)

SGLT2 Inhibitors and Cardiovascular Outcomes: Current Perspectives and Future Potentials

Authors: Xiaoming Jia, Paras B. Mehta, Yumei Ye, Mahboob Alam, Yochai Birnbaum, Mandeep Bajaj

Published in: Current Diabetes Reports | Issue 9/2018

Abstract

Purpose of Review

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been shown to exert benefit on cardiac outcomes. In this review, we provide updates on available clinical data, studies on potential mechanisms for the CV effects, as well as discuss potential clinical implications of these new findings.

Recent Findings

Since the publications of the EMPA-REG and CANVAS trials, large multi-national cohort studies have further shown the cardioprotective effects of SGLT2i. Moreover, new studies examining SGLT2i action on sodium-hydrogen exchanger proteins in both the heart and the kidney, on myocardial energetics and impact on inflammation and atherosclerosis continue to shed light on the multitude of pleotropic effects of these agents.

Summary

Though more data is needed to substantiate the safety and efficacy, SGLT2i should be considered as a valuable therapy to help reduce CV risk in patients with diabetes. Ultimately, SGLT2i may have utility in preventing progression to diabetes or providing CV protection in patients who do not have diabetes.

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Title: SGLT2 Inhibitors and Cardiovascular Outcomes: Current Perspectives and Future Potentials
Authors: Xiaoming Jia
Paras B. Mehta
Yumei Ye
Mahboob Alam
Yochai Birnbaum
Mandeep Bajaj
Publication date: 01-09-2018
Publisher: Springer US
Published in: Current Diabetes Reports / Issue 9/2018
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI: https://doi.org/10.1007/s11892-018-1038-9

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Abstract

Purpose of Review

Recent Findings

Summary

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