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Published in:

01-04-2011

Novel F-18–Labeled PET Myocardial Perfusion Tracers: Bench to Bedside

Authors: Stephan G. Nekolla, Antti Saraste

Published in: Current Cardiology Reports | Issue 2/2011

Abstract

Myocardial perfusion imaging is a widely used approach to noninvasively identify myocardial ischemia and guide therapies. It is typically performed using single photon emission computed tomography. The competing technology positron emission tomography (PET) offers higher diagnostic accuracies but suffers from logistical limitations due to the use of short-lived radioisotopes. New ¹⁸F-labeled perfusion markers were introduced in the past years and offer simplified supply approaches, as known from oncologic PET imaging. This review summarizes the available literature especially from preclinical studies, but also very recent findings from early clinical trials. We discuss the consequences of long-lived radioisotopes in myocardial PET and the potential role of absolute blood flow quantification to establish efficient clinical protocols.

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Title: Novel F-18–Labeled PET Myocardial Perfusion Tracers: Bench to Bedside
Authors: Stephan G. Nekolla
Antti Saraste
Publication date: 01-04-2011
Publisher: Current Science Inc.
Published in: Current Cardiology Reports / Issue 2/2011
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI: https://doi.org/10.1007/s11886-010-0159-9

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