Skip to main content
Top
Published in: Journal of Nuclear Cardiology 4/2009

01-08-2009 | Editorial Point of View

Quantification of myocardial blood flow will reform the detection of CAD

Authors: Juhani Knuuti, MD, Sami Kajander, MD, Maija Mäki, MD, Heikki Ukkonen, MD

Published in: Journal of Nuclear Cardiology | Issue 4/2009

Login to get access

Excerpt

The detection of functional consequences of epicardial coronary artery disease (CAD) has established role in guiding the therapy of the disease.1 In addition, the assessment of impairment in microcirculatory reactivity has recently gained more interest. Estimates of myocardial perfusion contain independent prognostic information about future major cardiac events and perfusion assessment is also useful in the monitoring of the effectiveness of risk reduction strategies.1
Literature
1.
go back to reference Klocke FJ, Baird MG, Lorell BH, Bateman TM, Messer JV, Berman DS, et al. ACC/AHA/ASNC guidelines for the clinical use of cardiac radionuclide imaging—executive summary: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASNC Committee to revise the 1995 Guidelines for the Clinical Use of Cardiac Radionuclide Imaging. Circulation 2003;108:1404-18.CrossRefPubMed Klocke FJ, Baird MG, Lorell BH, Bateman TM, Messer JV, Berman DS, et al. ACC/AHA/ASNC guidelines for the clinical use of cardiac radionuclide imaging—executive summary: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASNC Committee to revise the 1995 Guidelines for the Clinical Use of Cardiac Radionuclide Imaging. Circulation 2003;108:1404-18.CrossRefPubMed
2.
go back to reference Dijkmans PA, Knaapen P, Sieswerda GT, Aiazian E, Visser CA, Lammertsma AA, et al. Quantification of myocardial perfusion using intravenous myocardial contrast echocardiography in healthy volunteers: Comparison with positron emission tomography. J Am Soc Echocardiogr 2006;19:285-93.CrossRefPubMed Dijkmans PA, Knaapen P, Sieswerda GT, Aiazian E, Visser CA, Lammertsma AA, et al. Quantification of myocardial perfusion using intravenous myocardial contrast echocardiography in healthy volunteers: Comparison with positron emission tomography. J Am Soc Echocardiogr 2006;19:285-93.CrossRefPubMed
3.
go back to reference Fritz-Hansen T, Hove JD, Kofoed KF, Kelbaek H, Larsson HB. Quantification of MRI measured myocardial perfusion reserve in healthy humans: A comparison with positron emission tomography. J Magn Reson Imaging 2008;27:818-24.CrossRefPubMed Fritz-Hansen T, Hove JD, Kofoed KF, Kelbaek H, Larsson HB. Quantification of MRI measured myocardial perfusion reserve in healthy humans: A comparison with positron emission tomography. J Magn Reson Imaging 2008;27:818-24.CrossRefPubMed
4.
go back to reference Sampson UK, Dorbala S, Limaye A, Kwong R, Di Carli MF. Diagnostic accuracy of rubidium-82 myocardial perfusion imaging with hybrid positron emission tomography/computed tomography in the detection of coronary artery disease. J Am Coll Cardiol 2007;49:1052-8.CrossRefPubMed Sampson UK, Dorbala S, Limaye A, Kwong R, Di Carli MF. Diagnostic accuracy of rubidium-82 myocardial perfusion imaging with hybrid positron emission tomography/computed tomography in the detection of coronary artery disease. J Am Coll Cardiol 2007;49:1052-8.CrossRefPubMed
5.
go back to reference Muzik O, Duvernoy C, Beanlands RS, Sawada S, Dayanikli F, Wolfe ER Jr, et al. Assessment of diagnostic performance of quantitative flow measurements in normal subjects and patients with angiographically documented coronary artery disease by means of nitrogen-13 ammonia and positron emission tomography. J Am Coll Cardiol 1998;31:534-40.CrossRefPubMed Muzik O, Duvernoy C, Beanlands RS, Sawada S, Dayanikli F, Wolfe ER Jr, et al. Assessment of diagnostic performance of quantitative flow measurements in normal subjects and patients with angiographically documented coronary artery disease by means of nitrogen-13 ammonia and positron emission tomography. J Am Coll Cardiol 1998;31:534-40.CrossRefPubMed
6.
go back to reference Yoshinaga K, Katoh C, Noriyasu K, Iwado Y, Furuyama H, Ito Y, et al. Reduction of coronary flow reserve in areas with and without ischemia on stress perfusion imaging in patients with coronary artery disease: A study using oxygen 15-labeled water PET. J Nucl Cardiol 2003;10:275-83.CrossRefPubMed Yoshinaga K, Katoh C, Noriyasu K, Iwado Y, Furuyama H, Ito Y, et al. Reduction of coronary flow reserve in areas with and without ischemia on stress perfusion imaging in patients with coronary artery disease: A study using oxygen 15-labeled water PET. J Nucl Cardiol 2003;10:275-83.CrossRefPubMed
7.
go back to reference Parkash R, deKemp RA, Ruddy TD, Kitsikis A, Hart R, Beauchesne L, et al. Potential utility of rubidium 82 PET quantification in patients with 3-vessel coronary artery disease. J Nucl Cardiol 2004;11:440-9.CrossRefPubMed Parkash R, deKemp RA, Ruddy TD, Kitsikis A, Hart R, Beauchesne L, et al. Potential utility of rubidium 82 PET quantification in patients with 3-vessel coronary artery disease. J Nucl Cardiol 2004;11:440-9.CrossRefPubMed
8.
go back to reference Kajander S, Ukkonen H, Sipilä H, Teräs M, Knuuti J. Low radiation dose imaging of myocardial perfusion and coronary angiography with a hybrid PET/CT scanner. Clin Physiol Funct Imaging 2009;29:81-8.CrossRefPubMed Kajander S, Ukkonen H, Sipilä H, Teräs M, Knuuti J. Low radiation dose imaging of myocardial perfusion and coronary angiography with a hybrid PET/CT scanner. Clin Physiol Funct Imaging 2009;29:81-8.CrossRefPubMed
9.
go back to reference Iida H, Kanno I, Takahashi A, et al. Measurement of absolute myocardial blood flow with H2 15O and dynamic positron-emission tomography. Strategy for quantification in relation to the partial-volume effect. Circulation 1988;78:104-15.PubMed Iida H, Kanno I, Takahashi A, et al. Measurement of absolute myocardial blood flow with H2 15O and dynamic positron-emission tomography. Strategy for quantification in relation to the partial-volume effect. Circulation 1988;78:104-15.PubMed
10.
go back to reference Hutchins GD, Schwaiger M, Rosenspire KC, et al. Noninvasive quantification of regional blood flow in the human heart using N-13 ammonia and dynamic positron emission tomographic imaging. J Am Coll Cardiol 1990;15:1032-42.PubMedCrossRef Hutchins GD, Schwaiger M, Rosenspire KC, et al. Noninvasive quantification of regional blood flow in the human heart using N-13 ammonia and dynamic positron emission tomographic imaging. J Am Coll Cardiol 1990;15:1032-42.PubMedCrossRef
11.
go back to reference Herrero P, Markham J, Shelton ME, Weinheimer CJ, Bergmann SR. Noninvasive quantification of regional myocardial perfusion PET and myocardial perfusion with rubidium-82 and positron emission tomography. Exploration of a mathematical model. Circulation 1990;82:1377-86.PubMed Herrero P, Markham J, Shelton ME, Weinheimer CJ, Bergmann SR. Noninvasive quantification of regional myocardial perfusion PET and myocardial perfusion with rubidium-82 and positron emission tomography. Exploration of a mathematical model. Circulation 1990;82:1377-86.PubMed
12.
go back to reference Madar I, Ravert HT, Du Y, Hilton J, Volokh L, Dannals RF, et al. Characterization of uptake of the new PET imaging compound 18F-fluorobenzyl triphenyl phosphonium in dog myocardium. J Nucl Med 2006;47:1359-66.PubMed Madar I, Ravert HT, Du Y, Hilton J, Volokh L, Dannals RF, et al. Characterization of uptake of the new PET imaging compound 18F-fluorobenzyl triphenyl phosphonium in dog myocardium. J Nucl Med 2006;47:1359-66.PubMed
13.
go back to reference Huisman MC, Higuchi T, Reder S, Nekolla SG, Poethko T, Wester HJ, et al. Initial characterization of an 18F-labeled myocardial perfusion tracer. J Nucl Med 2008;49:630-6.CrossRefPubMed Huisman MC, Higuchi T, Reder S, Nekolla SG, Poethko T, Wester HJ, et al. Initial characterization of an 18F-labeled myocardial perfusion tracer. J Nucl Med 2008;49:630-6.CrossRefPubMed
14.
go back to reference Plössl K, Chandra R, Qu W, Lieberman BP, Kung MP, Zhou R, et al. A novel gallium bisaminothiolate complex as a myocardial perfusion imaging agent. Nucl Med Biol 2008;35:83-90.CrossRefPubMed Plössl K, Chandra R, Qu W, Lieberman BP, Kung MP, Zhou R, et al. A novel gallium bisaminothiolate complex as a myocardial perfusion imaging agent. Nucl Med Biol 2008;35:83-90.CrossRefPubMed
15.
go back to reference Muzik O, Beanlands RS, Hutchins GD, et al. Validation of nitrogen-13-ammonia tracer kinetic model for quantification of myocardial blood flow using PET. J Nucl Med 1993;34:83-91.PubMed Muzik O, Beanlands RS, Hutchins GD, et al. Validation of nitrogen-13-ammonia tracer kinetic model for quantification of myocardial blood flow using PET. J Nucl Med 1993;34:83-91.PubMed
16.
go back to reference Bol A, Melin JA, Vanoverschelde JL, et al. Direct comparison of [13 N]ammonia and [15O]water estimates of perfusion with quantification of regional myocardial blood flow by microspheres. Circulation 1993;87:512-25.PubMed Bol A, Melin JA, Vanoverschelde JL, et al. Direct comparison of [13 N]ammonia and [15O]water estimates of perfusion with quantification of regional myocardial blood flow by microspheres. Circulation 1993;87:512-25.PubMed
17.
go back to reference Lautamäki R, George RT, Kitagawa K, Higuchi T, Merrill J, Voicu C, et al. Rubidium-82 PET-CT for quantitative assessment of myocardial blood flow: Validation in a canine model of coronary artery stenosis. Eur J Nucl Med Mol Imaging 2009;36:576-86.CrossRefPubMed Lautamäki R, George RT, Kitagawa K, Higuchi T, Merrill J, Voicu C, et al. Rubidium-82 PET-CT for quantitative assessment of myocardial blood flow: Validation in a canine model of coronary artery stenosis. Eur J Nucl Med Mol Imaging 2009;36:576-86.CrossRefPubMed
18.
go back to reference Hesse B, Tägil K, Cuocolo A, Anagnostopoulos C, Bardiés M, Bax J, et al. EANM/ESC procedural guidelines for myocardial perfusion imaging in nuclear cardiology. Eur J Nucl Med Mol Imaging 2005;32:855-97.CrossRefPubMed Hesse B, Tägil K, Cuocolo A, Anagnostopoulos C, Bardiés M, Bax J, et al. EANM/ESC procedural guidelines for myocardial perfusion imaging in nuclear cardiology. Eur J Nucl Med Mol Imaging 2005;32:855-97.CrossRefPubMed
19.
go back to reference Gould KL, Pan T, Loghin C, Johnson NP, Guha A, Sdringola S. Frequent diagnostic errors in cardiac PET/CT due to misregistration of CT attenuation and emission PET images: A definitive analysis of causes, consequences, and corrections. J Nucl Med 2007;48:1112-21.CrossRefPubMed Gould KL, Pan T, Loghin C, Johnson NP, Guha A, Sdringola S. Frequent diagnostic errors in cardiac PET/CT due to misregistration of CT attenuation and emission PET images: A definitive analysis of causes, consequences, and corrections. J Nucl Med 2007;48:1112-21.CrossRefPubMed
20.
go back to reference Koepfli P, Hany TF, Wyss CA, Namdar M, Burger C, Konstantinidis AV, et al. CT attenuation correction for myocardial perfusion quantification using a PET/CT hybrid scanner. J Nucl Med 2004;45:537-42.PubMed Koepfli P, Hany TF, Wyss CA, Namdar M, Burger C, Konstantinidis AV, et al. CT attenuation correction for myocardial perfusion quantification using a PET/CT hybrid scanner. J Nucl Med 2004;45:537-42.PubMed
21.
go back to reference Kajander S, Ukkonen H, Joutsiniemi E, Mäki M, Saraste A, Ala-Knuuttila E, Pietilä M, Airaksinen J, Hartiala J, Saraste M, Knuuti J. The clinical value of absolute quantification of myocardial perfusion in the detection of coronary artery disease. A study using positron emission tomography to detect multi-vessel disease. Circulation 2008;118:S_1010-S_1011. Kajander S, Ukkonen H, Joutsiniemi E, Mäki M, Saraste A, Ala-Knuuttila E, Pietilä M, Airaksinen J, Hartiala J, Saraste M, Knuuti J. The clinical value of absolute quantification of myocardial perfusion in the detection of coronary artery disease. A study using positron emission tomography to detect multi-vessel disease. Circulation 2008;118:S_1010-S_1011.
22.
go back to reference Anagnostopoulos C, Almonacid A, El Fakhri G, Curillova Z, Sitek A, Roughton M, et al. Quantitative relationship between coronary vasodilator reserve assessed by 82Rb PET imaging and coronary artery stenosis severity. Eur J Nucl Med Mol Imaging 2008;35:1593-601.CrossRefPubMed Anagnostopoulos C, Almonacid A, El Fakhri G, Curillova Z, Sitek A, Roughton M, et al. Quantitative relationship between coronary vasodilator reserve assessed by 82Rb PET imaging and coronary artery stenosis severity. Eur J Nucl Med Mol Imaging 2008;35:1593-601.CrossRefPubMed
23.
go back to reference Nesterov SV, Han C, Mäki M, Kajander S, Naum AG, Helenius H, Lisinen I, Ukkonen H, Pietilä M, Joutsiniemi E, Knuuti J. Myocardial perfusion quantitation with 15O-water PET: High reproducibility of the new cardiac analysis software (CarimasTM) Eur J Nucl Med Mol Imaging 2009. [Epub ahead of print]. Nesterov SV, Han C, Mäki M, Kajander S, Naum AG, Helenius H, Lisinen I, Ukkonen H, Pietilä M, Joutsiniemi E, Knuuti J. Myocardial perfusion quantitation with 15O-water PET: High reproducibility of the new cardiac analysis software (CarimasTM) Eur J Nucl Med Mol Imaging 2009. [Epub ahead of print].
24.
go back to reference Dorbala S, Vangala D, Sampson U, Limaye A, Kwong R, Di Carli MF. Value of left ventricular ejection fraction reserve in evaluating the magnitude of myocardium at risk and the extent of angiographic coronary artery disease: A 82Rb PET/CT study. J Nucl Med 2007;48:349-58.PubMed Dorbala S, Vangala D, Sampson U, Limaye A, Kwong R, Di Carli MF. Value of left ventricular ejection fraction reserve in evaluating the magnitude of myocardium at risk and the extent of angiographic coronary artery disease: A 82Rb PET/CT study. J Nucl Med 2007;48:349-58.PubMed
25.
go back to reference Di Carli MF, Hachamovitch R. New technology for noninvasive evaluation of coronary artery disease. Circulation 2007;115:1464-80.CrossRefPubMed Di Carli MF, Hachamovitch R. New technology for noninvasive evaluation of coronary artery disease. Circulation 2007;115:1464-80.CrossRefPubMed
26.
go back to reference Bax JJ, Beanlands RS, Klocke FJ, Knuuti J, Lammertsma AA, Schaefers MA, et al. Diagnostic and clinical perspectives of fusion imaging in cardiology: Is the total greater than the sum of its parts? Heart 2007;93:16-22.CrossRefPubMed Bax JJ, Beanlands RS, Klocke FJ, Knuuti J, Lammertsma AA, Schaefers MA, et al. Diagnostic and clinical perspectives of fusion imaging in cardiology: Is the total greater than the sum of its parts? Heart 2007;93:16-22.CrossRefPubMed
27.
go back to reference O’Neill JO, McCarthy PM, Brunken RC, Buda T, Hoercher K, Young JB, et al. PET abnormalities in patients with nonischemic cardiomyopathy. J Card Fail 2004;10:244-9.CrossRefPubMed O’Neill JO, McCarthy PM, Brunken RC, Buda T, Hoercher K, Young JB, et al. PET abnormalities in patients with nonischemic cardiomyopathy. J Card Fail 2004;10:244-9.CrossRefPubMed
Metadata
Title
Quantification of myocardial blood flow will reform the detection of CAD
Authors
Juhani Knuuti, MD
Sami Kajander, MD
Maija Mäki, MD
Heikki Ukkonen, MD
Publication date
01-08-2009
Publisher
Springer-Verlag
Published in
Journal of Nuclear Cardiology / Issue 4/2009
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-009-9101-1

Other articles of this Issue 4/2009

Journal of Nuclear Cardiology 4/2009 Go to the issue