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Open Access 23-04-2022 | IM - REVIEW

Treatment options in obstructive sleep apnea

Authors: Francesco Gambino, Marta Maria Zammuto, Alessandro Virzì, Giosafat Conti, Maria Rosaria Bonsignore

Published in: Internal and Emergency Medicine | Issue 4/2022

Abstract

Treatment of OSA with CPAP is currently the recommended treatment and has the greatest evidence of efficacy on AHI, symptoms and comorbidities. Symptomatic patients with moderate-severe OSA generally have good adherence to CPAP therapy, while those with mild OSA, female, young and generally paucisymptomatic, have lower CPAP adherence, especially in the medium and long term. The recent identification of different clinical and pathophysiological phenotypes of OSA has paved the way for alternative treatments to CPAP, leading to an increasingly personalized therapy. Weight loss and lifestyle modifications are highly recommended in all obese or overweight patients. Mandibular advancement devices (MAD), positional therapy (PT) and hypoglossal nerve stimulation (HSN) are recent and personalized alternative therapies on which there is promising and encouraging data but with still little strong scientific evidence. The purpose of this review is to compare the efficacy, adherence and costs of various therapeutic options for OSA patients in the light of recent evidence and to provide useful guidance for specialists.

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Title: Treatment options in obstructive sleep apnea
Authors: Francesco Gambino
Marta Maria Zammuto
Alessandro Virzì
Giosafat Conti
Maria Rosaria Bonsignore
Publication date: 23-04-2022
Publisher: Springer International Publishing
Published in: Internal and Emergency Medicine / Issue 4/2022
Print ISSN: 1828-0447
Electronic ISSN: 1970-9366
DOI: https://doi.org/10.1007/s11739-022-02983-1

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Hospitalization and mortality for acute exacerbation of asthma: an Italian population-based study

Machine learning versus traditional methods for the development of risk stratification scores: a case study using original Canadian Syncope Risk Score data

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SGLT2i in patients with transthyretin cardiac amyloidosis, a well-tolerated option for heart failure treatment? Results from a small, real-world, patients series

Aging underlies heterogeneity between comorbidity and multimorbidity frameworks

Low in-hospital mortality rate in patients with COVID-19 receiving thromboprophylaxis: data from the multicentre observational START-COVID Register

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