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Published in: Current Sleep Medicine Reports 3/2017

Open Access 01-09-2017 | Sleep and Otolaryngology (H Gouveris, Section Editor)

Update on Oral Appliance Therapy for OSA

Author: M. Marklund

Published in: Current Sleep Medicine Reports | Issue 3/2017

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Abstract

Purpose of Review

The majority of the adult population is affected by obstructive sleep apnea (OSA), according to recent epidemiological research. Oral appliance (OA) therapy is increasingly recommended, particularly for patients with milder OSA. This review updates the evidence in favor of OA therapy.

Recent Findings

A high level of evidence shows that OA is effective in the treatment of OSA, but continuous positive airway pressure (CPAP) is more efficient. Higher adherence with OAs may compensate for this difference. Daytime sleepiness is better treated with CPAP than with OA in patients with severe OSA. In patients with milder OSA, it is unclear whether sleepiness is significantly reduced. The long-term effectiveness of OAs is uncertain because of side-effects and the risk of OSA deterioration.

Summary

OAs are effective, but their efficacy is more variable than that of CPAP. More research is needed about the mechanism of action of OA, subjective effects and long-term health outcomes.
Literature
5.
go back to reference Gakwaya S, Melo-Silva CA, Borel JC, Rousseau E, Masse JF, Series F. Impact of stepwise mandibular advancement on upper airway mechanics in obstructive sleep apnea using phrenic nerve magnetic stimulation. Respir Physiol Neurobiol. 2014;190:131–6. doi:10.1016/j.resp.2013.10.004.CrossRefPubMed Gakwaya S, Melo-Silva CA, Borel JC, Rousseau E, Masse JF, Series F. Impact of stepwise mandibular advancement on upper airway mechanics in obstructive sleep apnea using phrenic nerve magnetic stimulation. Respir Physiol Neurobiol. 2014;190:131–6. doi:10.​1016/​j.​resp.​2013.​10.​004.CrossRefPubMed
7.
go back to reference • Edwards BA, Eckert DJ, Jordan AS. Obstructive sleep apnoea pathogenesis from mild to severe: is it all the same? Respirology. 2017;22:33–42. doi:10.1111/resp.12913. Article providing more deep insights in OSA patophysiology in relation to desease severity CrossRefPubMed • Edwards BA, Eckert DJ, Jordan AS. Obstructive sleep apnoea pathogenesis from mild to severe: is it all the same? Respirology. 2017;22:33–42. doi:10.​1111/​resp.​12913. Article providing more deep insights in OSA patophysiology in relation to desease severity CrossRefPubMed
8.
go back to reference •• Edwards BA, Andara C, Landry S, Sands SA, Joosten SA, Owens RL, et al. Upper-airway collapsibility and loop gain predict the response to oral appliance therapy in obstructive sleep apnea patients. Am J Respir Crit Care Med. 2016;194:1413–22. doi:10.1164/rccm.201601-0099OC. The first study of physiological traits as predictors of OA success compared with more traditional ones CrossRefPubMed •• Edwards BA, Andara C, Landry S, Sands SA, Joosten SA, Owens RL, et al. Upper-airway collapsibility and loop gain predict the response to oral appliance therapy in obstructive sleep apnea patients. Am J Respir Crit Care Med. 2016;194:1413–22. doi:10.​1164/​rccm.​201601-0099OC. The first study of physiological traits as predictors of OA success compared with more traditional ones CrossRefPubMed
10.
go back to reference •• Ramar K, Dort LC, Katz SG, Lettieri CJ, Harrod CG, Thomas SM, et al. Clinical practice guideline for the treatment of obstructive sleep apnea and snoring with oral appliance therapy: an update for 2015. J Clin Sleep Med. 2015;11:773–827. doi:10.5664/jcsm.4858. The most recent guideline regarding OA therapy PubMedPubMedCentral •• Ramar K, Dort LC, Katz SG, Lettieri CJ, Harrod CG, Thomas SM, et al. Clinical practice guideline for the treatment of obstructive sleep apnea and snoring with oral appliance therapy: an update for 2015. J Clin Sleep Med. 2015;11:773–827. doi:10.​5664/​jcsm.​4858. The most recent guideline regarding OA therapy PubMedPubMedCentral
11.
go back to reference •• Sharples LD, Clutterbuck-James AL, Glover MJ, Bennett MS, Chadwick R, Pittman MA, et al. Meta-analysis of randomised controlled trials of oral mandibular advancement devices and continuous positive airway pressure for obstructive sleep apnoea-hypopnoea. Sleep Med Rev. 2016;27:108–24. doi:10.1016/j.smrv.2015.05.003. The most recent meta-analysis regarding OA therapy CrossRefPubMed •• Sharples LD, Clutterbuck-James AL, Glover MJ, Bennett MS, Chadwick R, Pittman MA, et al. Meta-analysis of randomised controlled trials of oral mandibular advancement devices and continuous positive airway pressure for obstructive sleep apnoea-hypopnoea. Sleep Med Rev. 2016;27:108–24. doi:10.​1016/​j.​smrv.​2015.​05.​003. The most recent meta-analysis regarding OA therapy CrossRefPubMed
12.
go back to reference Aarab G, Lobbezoo F, Heymans MW, Hamburger HL, Naeije M. Long-term follow-up of a randomized controlled trial of oral appliance therapy in obstructive sleep apnea. Respiration. 2011;82:162–8. doi:10.1159/000324580.CrossRefPubMed Aarab G, Lobbezoo F, Heymans MW, Hamburger HL, Naeije M. Long-term follow-up of a randomized controlled trial of oral appliance therapy in obstructive sleep apnea. Respiration. 2011;82:162–8. doi:10.​1159/​000324580.CrossRefPubMed
13.
go back to reference Almeida FR, Henrich N, Marra C, Lynd LD, Lowe AA, Tsuda H, et al. Patient preferences and experiences of CPAP and oral appliances for the treatment of obstructive sleep apnea: a qualitative analysis. Sleep Breath. 2013;17:659–66. doi:10.1007/s11325-012-0739-6.CrossRefPubMed Almeida FR, Henrich N, Marra C, Lynd LD, Lowe AA, Tsuda H, et al. Patient preferences and experiences of CPAP and oral appliances for the treatment of obstructive sleep apnea: a qualitative analysis. Sleep Breath. 2013;17:659–66. doi:10.​1007/​s11325-012-0739-6.CrossRefPubMed
14.
15.
go back to reference • Dieltjens M, Vroegop AV, Verbruggen AE, Wouters K, Willemen M, De Backer WA, et al. A promising concept of combination therapy for positional obstructive sleep apnea. Sleep Breath. 2015;19:637–44. doi:10.1007/s11325-014-1068-8. Study highlighting the possibilities to combine treatments CrossRefPubMed • Dieltjens M, Vroegop AV, Verbruggen AE, Wouters K, Willemen M, De Backer WA, et al. A promising concept of combination therapy for positional obstructive sleep apnea. Sleep Breath. 2015;19:637–44. doi:10.​1007/​s11325-014-1068-8. Study highlighting the possibilities to combine treatments CrossRefPubMed
16.
go back to reference Borel JC, Gakwaya S, Masse JF, Melo-Silva CA, Series F. Impact of CPAP interface and mandibular advancement device on upper airway mechanical properties assessed with phrenic nerve stimulation in sleep apnea patients. Respir Physiol Neurobiol. 2012;183:170–6. doi:10.1016/j.resp.2012.06.018.CrossRefPubMed Borel JC, Gakwaya S, Masse JF, Melo-Silva CA, Series F. Impact of CPAP interface and mandibular advancement device on upper airway mechanical properties assessed with phrenic nerve stimulation in sleep apnea patients. Respir Physiol Neurobiol. 2012;183:170–6. doi:10.​1016/​j.​resp.​2012.​06.​018.CrossRefPubMed
17.
go back to reference Kaminska M, Montpetit A, Mathieu A, Jobin V, Morisson F, Mayer P. Higher effective oronasal versus nasal continuous positive airway pressure in obstructive sleep apnea: effect of mandibular stabilization. Can Respir J. 2014;21:234–8.CrossRefPubMedPubMedCentral Kaminska M, Montpetit A, Mathieu A, Jobin V, Morisson F, Mayer P. Higher effective oronasal versus nasal continuous positive airway pressure in obstructive sleep apnea: effect of mandibular stabilization. Can Respir J. 2014;21:234–8.CrossRefPubMedPubMedCentral
18.
go back to reference Bartolucci ML, Bortolotti F, Raffaelli E, D’Anto V, Michelotti A, Alessandri Bonetti G. The effectiveness of different mandibular advancement amounts in OSA patients: a systematic review and meta-regression analysis. Sleep Breath. 2016;20:911–9. doi:10.1007/s11325-015-1307-7.CrossRefPubMed Bartolucci ML, Bortolotti F, Raffaelli E, D’Anto V, Michelotti A, Alessandri Bonetti G. The effectiveness of different mandibular advancement amounts in OSA patients: a systematic review and meta-regression analysis. Sleep Breath. 2016;20:911–9. doi:10.​1007/​s11325-015-1307-7.CrossRefPubMed
19.
go back to reference Hoekema A, Stegenga B, Wijkstra PJ, van der Hoeven JH, Meinesz AF, de Bont LG. Obstructive sleep apnea therapy. J Dent Res. 2008;87:882–7.CrossRefPubMed Hoekema A, Stegenga B, Wijkstra PJ, van der Hoeven JH, Meinesz AF, de Bont LG. Obstructive sleep apnea therapy. J Dent Res. 2008;87:882–7.CrossRefPubMed
20.
go back to reference Holley AB, Lettieri CJ, Shah AA. Efficacy of an adjustable oral appliance and comparison with continuous positive airway pressure for the treatment of obstructive sleep apnea syndrome. Chest. 2011;140:1511–6. doi:10.1378/chest.10-2851.CrossRefPubMed Holley AB, Lettieri CJ, Shah AA. Efficacy of an adjustable oral appliance and comparison with continuous positive airway pressure for the treatment of obstructive sleep apnea syndrome. Chest. 2011;140:1511–6. doi:10.​1378/​chest.​10-2851.CrossRefPubMed
21.
go back to reference Gjerde K, Lehmann S, Berge ME, Johansson AK, Johansson A. Oral appliance treatment in moderate and severe obstructive sleep apnea patients non-adherent to CPAP. J Oral Rehabil. 2016;43:249–58. doi:10.1111/joor.12376.CrossRefPubMed Gjerde K, Lehmann S, Berge ME, Johansson AK, Johansson A. Oral appliance treatment in moderate and severe obstructive sleep apnea patients non-adherent to CPAP. J Oral Rehabil. 2016;43:249–58. doi:10.​1111/​joor.​12376.CrossRefPubMed
22.
go back to reference Haviv Y, Bachar G, Aframian DJ, Almoznino G, Michaeli E, Benoliel R. A 2-year mean follow-up of oral appliance therapy for severe obstructive sleep apnea: a cohort study. Oral Dis. 2015;21:386–92. doi:10.1111/odi.12291.CrossRefPubMed Haviv Y, Bachar G, Aframian DJ, Almoznino G, Michaeli E, Benoliel R. A 2-year mean follow-up of oral appliance therapy for severe obstructive sleep apnea: a cohort study. Oral Dis. 2015;21:386–92. doi:10.​1111/​odi.​12291.CrossRefPubMed
24.
go back to reference Vroegop AV, Vanderveken OM, Dieltjens M, Wouters K, Saldien V, Braem MJ, et al. Sleep endoscopy with simulation bite for prediction of oral appliance treatment outcome. J Sleep Res. 2013;22:348–55. doi:10.1111/jsr.12008.CrossRefPubMed Vroegop AV, Vanderveken OM, Dieltjens M, Wouters K, Saldien V, Braem MJ, et al. Sleep endoscopy with simulation bite for prediction of oral appliance treatment outcome. J Sleep Res. 2013;22:348–55. doi:10.​1111/​jsr.​12008.CrossRefPubMed
25.
go back to reference De Corso E, Bastanza G, Della Marca G, Grippaudo C, Rizzotto G, Marchese MR, et al. Drug-induced sleep endoscopy as a selection tool for mandibular advancement therapy by oral device in patients with mild to moderate obstructive sleep apnoea. Acta Otorhinolaryngol Ital. 2015;35:426–32. doi:10.14639/0392-100X-959.PubMed De Corso E, Bastanza G, Della Marca G, Grippaudo C, Rizzotto G, Marchese MR, et al. Drug-induced sleep endoscopy as a selection tool for mandibular advancement therapy by oral device in patients with mild to moderate obstructive sleep apnoea. Acta Otorhinolaryngol Ital. 2015;35:426–32. doi:10.​14639/​0392-100X-959.PubMed
26.
go back to reference • Kastoer C, Dieltjens M, Oorts E, Hamans E, Braem MJ, Van de Heyning PH, et al. The use of remotely controlled mandibular positioner as a predictive screening tool for mandibular advancement device therapy in patients with obstructive sleep apnea through single-night progressive titration of the mandible: a systematic review. J Clin Sleep Med. 2016;12:1411–21. doi:10.5664/jcsm.6202. Important review about a remotely controlled device CrossRefPubMedPubMedCentral • Kastoer C, Dieltjens M, Oorts E, Hamans E, Braem MJ, Van de Heyning PH, et al. The use of remotely controlled mandibular positioner as a predictive screening tool for mandibular advancement device therapy in patients with obstructive sleep apnea through single-night progressive titration of the mandible: a systematic review. J Clin Sleep Med. 2016;12:1411–21. doi:10.​5664/​jcsm.​6202. Important review about a remotely controlled device CrossRefPubMedPubMedCentral
27.
go back to reference Remmers J, Charkhandeh S, Grosse J, Topor Z, Brant R, Santosham P, et al. Remotely controlled mandibular protrusion during sleep predicts therapeutic success with oral appliances in patients with obstructive sleep apnea. Sleep. 2013;36:1517–1525, 25A. doi:10.5665/sleep.3048.CrossRefPubMedPubMedCentral Remmers J, Charkhandeh S, Grosse J, Topor Z, Brant R, Santosham P, et al. Remotely controlled mandibular protrusion during sleep predicts therapeutic success with oral appliances in patients with obstructive sleep apnea. Sleep. 2013;36:1517–1525, 25A. doi:10.​5665/​sleep.​3048.CrossRefPubMedPubMedCentral
28.
go back to reference Sutherland K, Phillips CL, Davies A, Srinivasan VK, Dalci O, Yee BJ, et al. CPAP pressure for prediction of oral appliance treatment response in obstructive sleep apnea. J Clin Sleep Med. 2014;10:943–9. doi:10.5664/jcsm.4020.PubMedPubMedCentral Sutherland K, Phillips CL, Davies A, Srinivasan VK, Dalci O, Yee BJ, et al. CPAP pressure for prediction of oral appliance treatment response in obstructive sleep apnea. J Clin Sleep Med. 2014;10:943–9. doi:10.​5664/​jcsm.​4020.PubMedPubMedCentral
30.
go back to reference Dieltjens M, Braem MJ, Van de Heyning PH, Wouters K, Vanderveken OM. Prevalence and clinical significance of supine-dependent obstructive sleep apnea in patients using oral appliance therapy. J Clin Sleep Med. 2014;10:959–64. doi:10.5664/jcsm.4024.PubMedPubMedCentral Dieltjens M, Braem MJ, Van de Heyning PH, Wouters K, Vanderveken OM. Prevalence and clinical significance of supine-dependent obstructive sleep apnea in patients using oral appliance therapy. J Clin Sleep Med. 2014;10:959–64. doi:10.​5664/​jcsm.​4024.PubMedPubMedCentral
31.
32.
go back to reference Marklund M, Stenlund H, Franklin KA. Mandibular advancement devices in 630 men and women with obstructive sleep apnea and snoring: tolerability and predictors of treatment success. Chest. 2004;125:1270–8.CrossRefPubMed Marklund M, Stenlund H, Franklin KA. Mandibular advancement devices in 630 men and women with obstructive sleep apnea and snoring: tolerability and predictors of treatment success. Chest. 2004;125:1270–8.CrossRefPubMed
33.
34.
go back to reference Takaesu Y, Tsuiki S, Kobayashi M, Komada Y, Nakayama H, Inoue Y. Mandibular advancement device as a comparable treatment to nasal continuous positive airway pressure for positional obstructive sleep apnea. J Clin Sleep Med. 2016;12:1113–9. doi:10.5664/jcsm.6048.CrossRefPubMedPubMedCentral Takaesu Y, Tsuiki S, Kobayashi M, Komada Y, Nakayama H, Inoue Y. Mandibular advancement device as a comparable treatment to nasal continuous positive airway pressure for positional obstructive sleep apnea. J Clin Sleep Med. 2016;12:1113–9. doi:10.​5664/​jcsm.​6048.CrossRefPubMedPubMedCentral
36.
37.
go back to reference • Denolf PL, Vanderveken OM, Marklund ME, Braem MJ. The status of cephalometry in the prediction of non-CPAP treatment outcome in obstructive sleep apnea patients. Sleep Med Rev. 2016;27:56–73. doi:10.1016/j.smrv.2015.05.009. Comprehensive review about the possibilites to predict success with OA therapy based on cephalograms CrossRefPubMed • Denolf PL, Vanderveken OM, Marklund ME, Braem MJ. The status of cephalometry in the prediction of non-CPAP treatment outcome in obstructive sleep apnea patients. Sleep Med Rev. 2016;27:56–73. doi:10.​1016/​j.​smrv.​2015.​05.​009. Comprehensive review about the possibilites to predict success with OA therapy based on cephalograms CrossRefPubMed
39.
go back to reference Gotsopoulos H, Chen C, Qian J, Cistulli PA. Oral appliance therapy improves symptoms in obstructive sleep apnea: a randomized, controlled trial. Am J Respir Crit Care Med. 2002;166:743–8.CrossRefPubMed Gotsopoulos H, Chen C, Qian J, Cistulli PA. Oral appliance therapy improves symptoms in obstructive sleep apnea: a randomized, controlled trial. Am J Respir Crit Care Med. 2002;166:743–8.CrossRefPubMed
40.
go back to reference • Marklund M, Carlberg B, Forsgren L, Olsson T, Stenlund H, Franklin KA. Oral appliance therapy in patients with daytime sleepiness and snoring or mild to moderate sleep apnea: a randomized clinical trial. JAMA Intern Med. 2015;175:1278–85. doi:10.1001/jamainternmed.2015.2051. The first study of symptomatic effects of OAs in patients with milder OSA; i.e. those with primary indications for this therapy CrossRefPubMed • Marklund M, Carlberg B, Forsgren L, Olsson T, Stenlund H, Franklin KA. Oral appliance therapy in patients with daytime sleepiness and snoring or mild to moderate sleep apnea: a randomized clinical trial. JAMA Intern Med. 2015;175:1278–85. doi:10.​1001/​jamainternmed.​2015.​2051. The first study of symptomatic effects of OAs in patients with milder OSA; i.e. those with primary indications for this therapy CrossRefPubMed
42.
go back to reference Aarab G, Lobbezoo F, Hamburger HL, Naeije M. Oral appliance therapy versus nasal continuous positive airway pressure in obstructive sleep apnea: a randomized, placebo-controlled trial. Respiration. 2011;81:411–9. doi:10.1159/000319595.CrossRefPubMed Aarab G, Lobbezoo F, Hamburger HL, Naeije M. Oral appliance therapy versus nasal continuous positive airway pressure in obstructive sleep apnea: a randomized, placebo-controlled trial. Respiration. 2011;81:411–9. doi:10.​1159/​000319595.CrossRefPubMed
43.
44.
go back to reference Duran-Cantolla J, Crovetto-Martinez R, Alkhraisat MH, Crovetto M, Municio A, Kutz R, et al. Efficacy of mandibular advancement device in the treatment of obstructive sleep apnea syndrome: a randomized controlled crossover clinical trial. Med Oral Patol Oral Cir Bucal. 2015;20:e605–15.CrossRefPubMedPubMedCentral Duran-Cantolla J, Crovetto-Martinez R, Alkhraisat MH, Crovetto M, Municio A, Kutz R, et al. Efficacy of mandibular advancement device in the treatment of obstructive sleep apnea syndrome: a randomized controlled crossover clinical trial. Med Oral Patol Oral Cir Bucal. 2015;20:e605–15.CrossRefPubMedPubMedCentral
45.
go back to reference Hans MG, Nelson S, Luks VG, Lorkovich P, Baek SJ. Comparison of two dental devices for treatment of obstructive sleep apnea syndrome (OSAS). Am J Orthod Dentofac Orthop. 1997;111:562–70.CrossRef Hans MG, Nelson S, Luks VG, Lorkovich P, Baek SJ. Comparison of two dental devices for treatment of obstructive sleep apnea syndrome (OSAS). Am J Orthod Dentofac Orthop. 1997;111:562–70.CrossRef
46.
go back to reference Johnston CD, Gleadhill IC, Cinnamond MJ, Gabbey J, Burden DJ. Mandibular advancement appliances and obstructive sleep apnoea: a randomized clinical trial. Eur J Orthod. 2002;24:251–62.CrossRefPubMed Johnston CD, Gleadhill IC, Cinnamond MJ, Gabbey J, Burden DJ. Mandibular advancement appliances and obstructive sleep apnoea: a randomized clinical trial. Eur J Orthod. 2002;24:251–62.CrossRefPubMed
47.
go back to reference Mehta A, Qian J, Petocz P, Darendeliler MA, Cistulli PA. A randomized, controlled study of a mandibular advancement splint for obstructive sleep apnea. Am J Respir Crit Care Med. 2001;163:1457–61.CrossRefPubMed Mehta A, Qian J, Petocz P, Darendeliler MA, Cistulli PA. A randomized, controlled study of a mandibular advancement splint for obstructive sleep apnea. Am J Respir Crit Care Med. 2001;163:1457–61.CrossRefPubMed
48.
49.
go back to reference Antic NA, Catcheside P, Buchan C, Hensley M, Naughton MT, Rowland S, et al. The effect of CPAP in normalizing daytime sleepiness, quality of life, and neurocognitive function in patients with moderate to severe OSA. Sleep. 2011;34:111–9.CrossRefPubMedPubMedCentral Antic NA, Catcheside P, Buchan C, Hensley M, Naughton MT, Rowland S, et al. The effect of CPAP in normalizing daytime sleepiness, quality of life, and neurocognitive function in patients with moderate to severe OSA. Sleep. 2011;34:111–9.CrossRefPubMedPubMedCentral
50.
go back to reference • Verbruggen AE, Dieltjens M, Wouters K, De Volder I, Van de Heyning PH, Braem MJ, et al. Prevalence of residual excessive sleepiness during effective oral appliance therapy for sleep-disordered breathing. Sleep Med. 2014;15:269–72. doi:10.1016/j.sleep.2013.11.781. Study describing residual daytime sleepiness despite a sufficient AHI-reduction of OA therapy CrossRefPubMed • Verbruggen AE, Dieltjens M, Wouters K, De Volder I, Van de Heyning PH, Braem MJ, et al. Prevalence of residual excessive sleepiness during effective oral appliance therapy for sleep-disordered breathing. Sleep Med. 2014;15:269–72. doi:10.​1016/​j.​sleep.​2013.​11.​781. Study describing residual daytime sleepiness despite a sufficient AHI-reduction of OA therapy CrossRefPubMed
51.
go back to reference Saletu A, Anderer P, Parapatics S, Matthai C, Matejka M, Saletu B. Effects of a mandibular repositioning appliance on sleep structure, morning behavior and clinical symptomatology in patients with snoring and sleep-disordered breathing. Neuropsychobiology. 2007;55:184–93. doi:10.1159/000107071.CrossRefPubMed Saletu A, Anderer P, Parapatics S, Matthai C, Matejka M, Saletu B. Effects of a mandibular repositioning appliance on sleep structure, morning behavior and clinical symptomatology in patients with snoring and sleep-disordered breathing. Neuropsychobiology. 2007;55:184–93. doi:10.​1159/​000107071.CrossRefPubMed
54.
57.
go back to reference Ferguson KA, Ono T, Lowe AA, al-Majed S, Love LL, Fleetham JA. A short-term controlled trial of an adjustable oral appliance for the treatment of mild to moderate obstructive sleep apnoea. Thorax. 1997;52:362–8.CrossRefPubMedPubMedCentral Ferguson KA, Ono T, Lowe AA, al-Majed S, Love LL, Fleetham JA. A short-term controlled trial of an adjustable oral appliance for the treatment of mild to moderate obstructive sleep apnoea. Thorax. 1997;52:362–8.CrossRefPubMedPubMedCentral
58.
go back to reference Ferguson KA, Ono T, Lowe AA, Keenan SP, Fleetham JA. A randomized crossover study of an oral appliance vs nasal-continuous positive airway pressure in the treatment of mild-moderate obstructive sleep apnea. Chest. 1996;109:1269–75.CrossRefPubMed Ferguson KA, Ono T, Lowe AA, Keenan SP, Fleetham JA. A randomized crossover study of an oral appliance vs nasal-continuous positive airway pressure in the treatment of mild-moderate obstructive sleep apnea. Chest. 1996;109:1269–75.CrossRefPubMed
59.
go back to reference Gagnadoux F, Fleury B, Vielle B, Petelle B, Meslier N, N'Guyen XL, et al. Titrated mandibular advancement versus positive airway pressure for sleep apnoea. Eur Respir J. 2009;34:914–20. doi:10.1183/09031936.00148208. Gagnadoux F, Fleury B, Vielle B, Petelle B, Meslier N, N'Guyen XL, et al. Titrated mandibular advancement versus positive airway pressure for sleep apnoea. Eur Respir J. 2009;34:914–20. doi:10.​1183/​09031936.​00148208.
60.
go back to reference • Dieltjens M, Verbruggen AE, Braem MJ, Wouters K, Verbraecken JA, De Backer WA, et al. Determinants of objective compliance during oral appliance therapy in patients with sleep-disordered breathing: a prospective clinical trial. JAMA Otolaryngol Head Neck Surg. 2015;141:894–900. doi:10.1001/jamaoto.2015.1756. First study of predictors of objective compliance CrossRefPubMed • Dieltjens M, Verbruggen AE, Braem MJ, Wouters K, Verbraecken JA, De Backer WA, et al. Determinants of objective compliance during oral appliance therapy in patients with sleep-disordered breathing: a prospective clinical trial. JAMA Otolaryngol Head Neck Surg. 2015;141:894–900. doi:10.​1001/​jamaoto.​2015.​1756. First study of predictors of objective compliance CrossRefPubMed
61.
go back to reference • Bratton DJ, Gaisl T, Wons AM, Kohler M. CPAP vs mandibular advancement devices and blood pressure in patients with obstructive sleep apnea: a systematic review and meta-analysis. JAMA. 2015;314:2280–93. doi:10.1001/jama.2015.16303. Up-to-date meta-analysis of the effects on blood pressure of OA compared with CPAP CrossRefPubMed • Bratton DJ, Gaisl T, Wons AM, Kohler M. CPAP vs mandibular advancement devices and blood pressure in patients with obstructive sleep apnea: a systematic review and meta-analysis. JAMA. 2015;314:2280–93. doi:10.​1001/​jama.​2015.​16303. Up-to-date meta-analysis of the effects on blood pressure of OA compared with CPAP CrossRefPubMed
62.
go back to reference Barnes M, McEvoy RD, Banks S, Tarquinio N, Murray CG, Vowles N, et al. Efficacy of positive airway pressure and oral appliance in mild to moderate obstructive sleep apnea. Am J Respir Crit Care Med. 2004;170:656–64. doi:10.1164/rccm.200311-1571OC.CrossRefPubMed Barnes M, McEvoy RD, Banks S, Tarquinio N, Murray CG, Vowles N, et al. Efficacy of positive airway pressure and oral appliance in mild to moderate obstructive sleep apnea. Am J Respir Crit Care Med. 2004;170:656–64. doi:10.​1164/​rccm.​200311-1571OC.CrossRefPubMed
64.
go back to reference Anandam A, Patil M, Akinnusi M, Jaoude P, El-Solh AA. Cardiovascular mortality in obstructive sleep apnoea treated with continuous positive airway pressure or oral appliance: an observational study. Respirology. 2013;18:1184–90. doi:10.1111/resp.12140.CrossRefPubMed Anandam A, Patil M, Akinnusi M, Jaoude P, El-Solh AA. Cardiovascular mortality in obstructive sleep apnoea treated with continuous positive airway pressure or oral appliance: an observational study. Respirology. 2013;18:1184–90. doi:10.​1111/​resp.​12140.CrossRefPubMed
65.
go back to reference Galic T, Bozic J, Ivkovic N, Gunjaca G, Ticinovic TK, Dogas Z. Effects of mandibular advancement device treatment on arterial stiffness and glucose metabolism in patients with mild to moderate obstructive sleep apnea: a prospective 1 year study. Sleep Breath. 2016;20:69–77. doi:10.1007/s11325-015-1186-y.CrossRefPubMed Galic T, Bozic J, Ivkovic N, Gunjaca G, Ticinovic TK, Dogas Z. Effects of mandibular advancement device treatment on arterial stiffness and glucose metabolism in patients with mild to moderate obstructive sleep apnea: a prospective 1 year study. Sleep Breath. 2016;20:69–77. doi:10.​1007/​s11325-015-1186-y.CrossRefPubMed
68.
go back to reference Phillips CL, Grunstein RR, Darendeliler MA, Mihailidou AS, Srinivasan VK, Yee BJ, et al. Health outcomes of continuous positive airway pressure versus oral appliance treatment for obstructive sleep apnea: a randomized controlled trial. Am J Respir Crit Care Med. 2013;187:879–87. doi:10.1164/rccm.201212-2223OC.CrossRefPubMed Phillips CL, Grunstein RR, Darendeliler MA, Mihailidou AS, Srinivasan VK, Yee BJ, et al. Health outcomes of continuous positive airway pressure versus oral appliance treatment for obstructive sleep apnea: a randomized controlled trial. Am J Respir Crit Care Med. 2013;187:879–87. doi:10.​1164/​rccm.​201212-2223OC.CrossRefPubMed
69.
go back to reference Dieltjens M, Braem MJ, Vroegop AV, Wouters K, Verbraecken JA, De Backer WA, et al. Objectively measured vs self-reported compliance during oral appliance therapy for sleep-disordered breathing. Chest. 2013;144:1495–502. doi:10.1378/chest.13-0613.CrossRefPubMed Dieltjens M, Braem MJ, Vroegop AV, Wouters K, Verbraecken JA, De Backer WA, et al. Objectively measured vs self-reported compliance during oral appliance therapy for sleep-disordered breathing. Chest. 2013;144:1495–502. doi:10.​1378/​chest.​13-0613.CrossRefPubMed
71.
go back to reference Gonzalez M, Macias-Escalada E, Cobo J, Fernandez Mondragon MP, Gomez-Moreno G, Martinez-Martinez M, et al. Can treatment with statins have a negative influence on the tolerance of mandibular advancement devices? Sleep Breath. 2016;20:1363–6. doi:10.1007/s11325-016-1399-8.CrossRefPubMed Gonzalez M, Macias-Escalada E, Cobo J, Fernandez Mondragon MP, Gomez-Moreno G, Martinez-Martinez M, et al. Can treatment with statins have a negative influence on the tolerance of mandibular advancement devices? Sleep Breath. 2016;20:1363–6. doi:10.​1007/​s11325-016-1399-8.CrossRefPubMed
73.
go back to reference Doff MH, Finnema KJ, Hoekema A, Wijkstra PJ, de Bont LG, Stegenga B. Long-term oral appliance therapy in obstructive sleep apnea syndrome: a controlled study on dental side effects. Clin Oral Investig. 2013;17:475–82. doi:10.1007/s00784-012-0737-x.CrossRefPubMed Doff MH, Finnema KJ, Hoekema A, Wijkstra PJ, de Bont LG, Stegenga B. Long-term oral appliance therapy in obstructive sleep apnea syndrome: a controlled study on dental side effects. Clin Oral Investig. 2013;17:475–82. doi:10.​1007/​s00784-012-0737-x.CrossRefPubMed
74.
go back to reference Perez CV, de Leeuw R, Okeson JP, Carlson CR, Li HF, Bush HM, et al. The incidence and prevalence of temporomandibular disorders and posterior open bite in patients receiving mandibular advancement device therapy for obstructive sleep apnea. Sleep Breath. 2013;17:323–32. doi:10.1007/s11325-012-0695-1.CrossRefPubMed Perez CV, de Leeuw R, Okeson JP, Carlson CR, Li HF, Bush HM, et al. The incidence and prevalence of temporomandibular disorders and posterior open bite in patients receiving mandibular advancement device therapy for obstructive sleep apnea. Sleep Breath. 2013;17:323–32. doi:10.​1007/​s11325-012-0695-1.CrossRefPubMed
75.
go back to reference Almeida FR, Lowe AA, Otsuka R, Fastlicht S, Farbood M, Tsuiki S. Long-term sequellae of oral appliance therapy in obstructive sleep apnea patients: part 2. Study-model analysis. Am J Orthod Dentofac Orthop. 2006;129:205–13. doi:10.1016/j.ajodo.2005.04.034.CrossRef Almeida FR, Lowe AA, Otsuka R, Fastlicht S, Farbood M, Tsuiki S. Long-term sequellae of oral appliance therapy in obstructive sleep apnea patients: part 2. Study-model analysis. Am J Orthod Dentofac Orthop. 2006;129:205–13. doi:10.​1016/​j.​ajodo.​2005.​04.​034.CrossRef
77.
go back to reference • Pliska BT, Nam H, Chen H, Lowe AA, Almeida FR. Obstructive sleep apnea and mandibular advancement splints: occlusal effects and progression of changes associated with a decade of treatment. J Clin Sleep Med. 2014;10:1285–91. doi:10.5664/jcsm.4278. The longest follow-up of dental side-effects of OA therapy in a large sample PubMedPubMedCentral • Pliska BT, Nam H, Chen H, Lowe AA, Almeida FR. Obstructive sleep apnea and mandibular advancement splints: occlusal effects and progression of changes associated with a decade of treatment. J Clin Sleep Med. 2014;10:1285–91. doi:10.​5664/​jcsm.​4278. The longest follow-up of dental side-effects of OA therapy in a large sample PubMedPubMedCentral
79.
go back to reference Marklund M, Franklin KA, Persson M. Orthodontic side-effects of mandibular advancement devices during treatment of snoring and sleep apnoea. Eur J Orthod. 2001;23:135–44.CrossRefPubMed Marklund M, Franklin KA, Persson M. Orthodontic side-effects of mandibular advancement devices during treatment of snoring and sleep apnoea. Eur J Orthod. 2001;23:135–44.CrossRefPubMed
80.
go back to reference Pantin CC, Hillman DR, Tennant M. Dental side effects of an oral device to treat snoring and obstructive sleep apnea. Sleep. 1999;22:237–40.CrossRefPubMed Pantin CC, Hillman DR, Tennant M. Dental side effects of an oral device to treat snoring and obstructive sleep apnea. Sleep. 1999;22:237–40.CrossRefPubMed
81.
82.
go back to reference Fransson AM, Tegelberg A, Leissner L, Wenneberg B, Isacsson G. Effects of a mandibular protruding device on the sleep of patients with obstructive sleep apnea and snoring problems: a 2-year follow-up. Sleep Breath. 2003;7:131–41. doi:10.1007/s11325-003-0131-7.CrossRefPubMed Fransson AM, Tegelberg A, Leissner L, Wenneberg B, Isacsson G. Effects of a mandibular protruding device on the sleep of patients with obstructive sleep apnea and snoring problems: a 2-year follow-up. Sleep Breath. 2003;7:131–41. doi:10.​1007/​s11325-003-0131-7.CrossRefPubMed
85.
go back to reference Marklund M, Sahlin C, Stenlund H, Persson M, Franklin KA. Mandibular advancement device in patients with obstructive sleep apnea: long-term effects on apnea and sleep. Chest. 2001;120:162–9.CrossRefPubMed Marklund M, Sahlin C, Stenlund H, Persson M, Franklin KA. Mandibular advancement device in patients with obstructive sleep apnea: long-term effects on apnea and sleep. Chest. 2001;120:162–9.CrossRefPubMed
86.
go back to reference Rose EC, Barthlen GM, Staats R, Jonas IE. Therapeutic efficacy of an oral appliance in the treatment of obstructive sleep apnea: a 2-year follow-up. Am J Orthod Dentofac Orthop. 2002;121:273–9.CrossRef Rose EC, Barthlen GM, Staats R, Jonas IE. Therapeutic efficacy of an oral appliance in the treatment of obstructive sleep apnea: a 2-year follow-up. Am J Orthod Dentofac Orthop. 2002;121:273–9.CrossRef
87.
88.
go back to reference Walker-Engstrom ML, Tegelberg A, Wilhelmsson B, Ringqvist I. 4-year follow-up of treatment with dental appliance or uvulopalatopharyngoplasty in patients with obstructive sleep apnea: a randomized study. Chest. 2002;121:739–46.CrossRefPubMed Walker-Engstrom ML, Tegelberg A, Wilhelmsson B, Ringqvist I. 4-year follow-up of treatment with dental appliance or uvulopalatopharyngoplasty in patients with obstructive sleep apnea: a randomized study. Chest. 2002;121:739–46.CrossRefPubMed
90.
go back to reference Senaratna CV, Perret JL, Lodge CJ, Lowe AJ, Campbell BE, Matheson MC, et al. Prevalence of obstructive sleep apnea in the general population: a systematic review. Sleep Med Rev. 2016; doi:10.1016/j.smrv.2016.07.002. Senaratna CV, Perret JL, Lodge CJ, Lowe AJ, Campbell BE, Matheson MC, et al. Prevalence of obstructive sleep apnea in the general population: a systematic review. Sleep Med Rev. 2016; doi:10.​1016/​j.​smrv.​2016.​07.​002.
91.
go back to reference McGown AD, Makker HK, Battagel JM, L'Estrange PR, Grant HR, Spiro SG. Long-term use of mandibular advancement splints for snoring and obstructive sleep apnoea: a questionnaire survey. Eur Respir J. 2001;17:462–6.CrossRefPubMed McGown AD, Makker HK, Battagel JM, L'Estrange PR, Grant HR, Spiro SG. Long-term use of mandibular advancement splints for snoring and obstructive sleep apnoea: a questionnaire survey. Eur Respir J. 2001;17:462–6.CrossRefPubMed
92.
go back to reference Zhou J, Liu YH. A randomised titrated crossover study comparing two oral appliances in the treatment for mild to moderate obstructive sleep apnoea/hypopnoea syndrome. J Oral Rehabil. 2012;39:914–22. doi:10.1111/joor.12006.CrossRefPubMed Zhou J, Liu YH. A randomised titrated crossover study comparing two oral appliances in the treatment for mild to moderate obstructive sleep apnoea/hypopnoea syndrome. J Oral Rehabil. 2012;39:914–22. doi:10.​1111/​joor.​12006.CrossRefPubMed
93.
go back to reference Friedman M, Hamilton C, Samuelson CG, Kelley K, Pearson-Chauhan K, Taylor D, et al. Compliance and efficacy of titratable thermoplastic versus custom mandibular advancement devices. Otolaryngol Head Neck Surg. 2012;147:379–86. doi:10.1177/0194599812439683.CrossRefPubMed Friedman M, Hamilton C, Samuelson CG, Kelley K, Pearson-Chauhan K, Taylor D, et al. Compliance and efficacy of titratable thermoplastic versus custom mandibular advancement devices. Otolaryngol Head Neck Surg. 2012;147:379–86. doi:10.​1177/​0194599812439683​.CrossRefPubMed
94.
go back to reference Vanderveken OM, Devolder A, Marklund M, Boudewyns AN, Braem MJ, Okkerse W, et al. Comparison of a custom-made and a thermoplastic oral appliance for the treatment of mild sleep apnea. Am J Respir Crit Care Med. 2008;178:197–202. doi:10.1164/rccm.200701-114OC.CrossRefPubMed Vanderveken OM, Devolder A, Marklund M, Boudewyns AN, Braem MJ, Okkerse W, et al. Comparison of a custom-made and a thermoplastic oral appliance for the treatment of mild sleep apnea. Am J Respir Crit Care Med. 2008;178:197–202. doi:10.​1164/​rccm.​200701-114OC.CrossRefPubMed
96.
97.
go back to reference Ringqvist M, Walker-Engstrom ML, Tegelberg A, Ringqvist I. Dental and skeletal changes after 4 years of obstructive sleep apnea treatment with a mandibular advancement device: a prospective, randomized study. Am J Orthod Dentofac Orthop. 2003;124:53–60. doi:10.1016/S0889540603002403.CrossRef Ringqvist M, Walker-Engstrom ML, Tegelberg A, Ringqvist I. Dental and skeletal changes after 4 years of obstructive sleep apnea treatment with a mandibular advancement device: a prospective, randomized study. Am J Orthod Dentofac Orthop. 2003;124:53–60. doi:10.​1016/​S088954060300240​3.CrossRef
99.
go back to reference • Marshall NS, Wong KK, Cullen SR, Knuiman MW, Grunstein RR. Sleep apnea and 20-year follow-up for all-cause mortality, stroke, and cancer incidence and mortality in the Busselton Health Study cohort. J Clin Sleep Med. 2014;10:355–62. doi:10.5664/jcsm.3600. Important data that reflect treatment needs of milder OSA PubMedPubMedCentral • Marshall NS, Wong KK, Cullen SR, Knuiman MW, Grunstein RR. Sleep apnea and 20-year follow-up for all-cause mortality, stroke, and cancer incidence and mortality in the Busselton Health Study cohort. J Clin Sleep Med. 2014;10:355–62. doi:10.​5664/​jcsm.​3600. Important data that reflect treatment needs of milder OSA PubMedPubMedCentral
101.
go back to reference Tegelberg A, Nohlert E, Bergman LE, Andren A. Bed partners’ and patients’ experiences after treatment of obstructive sleep apnoea with an oral appliance. Swed Dent J. 2012;36:35–44.PubMed Tegelberg A, Nohlert E, Bergman LE, Andren A. Bed partners’ and patients’ experiences after treatment of obstructive sleep apnoea with an oral appliance. Swed Dent J. 2012;36:35–44.PubMed
Metadata
Title
Update on Oral Appliance Therapy for OSA
Author
M. Marklund
Publication date
01-09-2017
Publisher
Springer International Publishing
Published in
Current Sleep Medicine Reports / Issue 3/2017
Electronic ISSN: 2198-6401
DOI
https://doi.org/10.1007/s40675-017-0080-5

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