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Open Access 01-12-2020 | Forearm Fracture | Original Article

Epidemiology of osteoporotic fracture in Moldova and development of a country-specific FRAX model

Authors: Alla Zakroyeva, Olga Lesnyak, Victor Cazac, Liliana Groppa, Eugen Russu, Lia Chislari, Larisa Rotaru, Helena Johansson, Nicholas C. Harvey, Eugene McCloskey, Mattis Lorentzon, John A. Kanis

Published in: Archives of Osteoporosis | Issue 1/2020

Abstract

Summary

Retrospective population-based survey in 2 regions of the Republic of Moldova determined the incidence of fractures at the hip, proximal humerus and distal forearm. The estimated number of such fractures nationwide for 2015 was 11,271 and is predicted to increase to 15,863 in 2050. The hip fracture rates were used to create a FRAX model to help guide decisions about treatment.

Objective

This paper describes the epidemiology of osteoporotic fractures in Republic of Moldova that was used to develop the country-specific fracture prediction FRAX® tool.

Methods

We carried out a retrospective population-based survey in 2 regions of the Republic of Moldova (Anenii Noi district and Orhei district) representing approximately 6% of the country’s population. We identified hip, forearm and humerus fractures in 2011 and 2012 from hospital registers and primary care sources. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Moldova. Fracture probabilities were compared with those from neighbouring countries having FRAX models.

Results

The incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2015 was 3911 and is predicted to increase by 60% to 6492 in 2050. Hip fracture incidence was a good predictor of forearm and humeral fractures. FRAX-based probabilities were higher in Moldova than neighbouring countries (Ukraine and Romania).

Conclusion

The FRAX model should enhance accuracy of determining fracture probability among the Moldavan population and help guide decisions about treatment.

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Title: Epidemiology of osteoporotic fracture in Moldova and development of a country-specific FRAX model
Authors: Alla Zakroyeva
Olga Lesnyak
Victor Cazac
Liliana Groppa
Eugen Russu
Lia Chislari
Larisa Rotaru
Helena Johansson
Nicholas C. Harvey
Eugene McCloskey
Mattis Lorentzon
John A. Kanis
Publication date: 01-12-2020
Publisher: Springer London
Keyword: Forearm Fracture
Published in: Archives of Osteoporosis / Issue 1/2020
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-019-0669-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Epidemiology of osteoporotic fracture in Moldova and development of a country-specific FRAX model

Abstract

Summary

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Objective

Methods

Results

Conclusion

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