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Archives of Osteoporosis

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01-12-2012 | Original Article

Bone health status of premenopausal healthy adult females in Pakistani females

Authors: Farhan Javed Dar, Romaina Iqbal, Farooq Ghani, Imran Siddiqui, Aysha Habib Khan

Published in: Archives of Osteoporosis | Issue 1-2/2012

Abstract

Summary

Bone health status in healthy premenopausal females was assessed. We found high bone turnover in 36.8 % and vitamin D deficiency and insufficiency in 82.8 and 16.1 %, respectively, and secondary hyperparathyroidism in 25.9 % of the subjects. This is alarming as there is inability to achieve peak bone mass and predisposes to osteoporosis risk.

Purpose

This study aimed to assess bone health status in healthy females by using biochemical markers of bone metabolism in blood [N-telopeptide of type I collagen (NTx), 25-hydroxyvitamin D (25OHD), and plasma intact parathyroid hormone (iPTH)].

Material and methods

One hundred and seventy-four healthy premenopausal female volunteers were recruited from an urban residential area in Karachi. Demographic details were collected on a preformed questionnaire. Blood samples for the estimation of serum NTx, 25OHD, and plasma iPTH were taken in a fasting state. Data were analyzed using Statistical Package for Social Sciences 16.0. A p value of <0.05 was considered as significant.

Results

High bone turnover, as depicted by NTx, was seen in 36.8 % cases. Vitamin D deficiency, insufficiency, and sufficiency were seen in 82.8, 16.1, and 1.1 % respectively. Secondary hyperparathyroidism was present in 25.9 % of the subjects, while others had blunted PTH response. Significant correlates of bone health were serum 25OHD levels, duration of sun exposure, and the practice of wearing veil (p value < 0.001).

Conclusion

Bone turnover is high with high prevalence of vitamin D deficiency in apparently healthy premenopausal females predisposing them to higher risk for development of osteoporosis.

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Title: Bone health status of premenopausal healthy adult females in Pakistani females
Authors: Farhan Javed Dar
Romaina Iqbal
Farooq Ghani
Imran Siddiqui
Aysha Habib Khan
Publication date: 01-12-2012
Publisher: Springer-Verlag
Published in: Archives of Osteoporosis / Issue 1-2/2012
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-012-0085-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Bone health status of premenopausal healthy adult females in Pakistani females

Abstract

Summary

Purpose

Material and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Purpose

Material and methods

Results

Conclusion

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