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Published in: Archives of Osteoporosis 1-2/2012

01-12-2012 | Original Article

Widespread vitamin D deficiency among Indian health care professionals

Authors: Maria Beloyartseva, Ambrish Mithal, Parjeet Kaur, Sanjay Kalra, Manash P. Baruah, Satinath Mukhopadhyay, Ganapathy Bantwal, Tushar R. Bandgar

Published in: Archives of Osteoporosis | Issue 1-2/2012

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Abstract

Summary

Information on vitamin D status of Indian health care professionals is limited. Among 2,119 subjects studied, just 6 % were found to be sufficient in vitamin D status. There is urgent need of an integrated approach to detect and treat vitamin D deficiency among health care professionals to improve on-the-job productivity.

Introduction

Vitamin D deficiency is prevalent worldwide. India has been reported to be one of the worst affected countries. Several single-center studies from India have shown high prevalence of vitamin D deficiency. Little is known regarding the vitamin D status of Indian health care professionals.

Aim

This study aimed to determine prevalence of vitamin D deficiency among health care professionals in different regions of India.

Method

In this cross-sectional, multicenter study, we enrolled 2,119 medical and paramedical personnel from 18 Indian cities. Blood samples were collected from December 2010 to March 2011 and analyzed in a central laboratory by radioimmunoassay. Vitamin D deficiency was defined as 25-hydroxyvitamin D [25(OH)D] <20 ng/mL or <50 nmol/L, insufficiency as 25(OH)D = 20–30 ng/mL or 50–75 nmol/L, and sufficiency as 25(OH)D >30 ng/mL or >75 nmol/L.

Results

Mean (±SD) age of subjects was 42.71 ± 6.8 years. Mean (±SD) 25(OH)D level was 14.35 ± 10.62 ng/mL (median 11.93 ng/mL). Seventy-nine percent of subjects were deficient, 15 % were insufficient, and just 6 % were sufficient in vitamin D status. No significant difference was found between vitamin D status in southern (25(OH)D = 13.3 ± 6.4 ng/mL) and northern (25(OH)D = 14.4 ± 8.5 ng/mL) parts of India.

Conclusion

Our study confirms the high prevalence of vitamin D deficiency all across India in apparently healthy, middle-aged health care professionals.
Literature
1.
go back to reference Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, El-Hajj Fuleihan G, Josse RG, Lips P, Morales-Torres J (2009) Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 20:1807–1820PubMedCrossRef Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, El-Hajj Fuleihan G, Josse RG, Lips P, Morales-Torres J (2009) Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 20:1807–1820PubMedCrossRef
2.
go back to reference Goswami R, Gupta N, Goswami D, Marwaha RK, Tandon N, Kochupillai N (2000) Prevalence and significance of low 25-hydroxyvitamin D concentrations in healthy subjects in Delhi. Am J Clin Nutr 72:472–475PubMed Goswami R, Gupta N, Goswami D, Marwaha RK, Tandon N, Kochupillai N (2000) Prevalence and significance of low 25-hydroxyvitamin D concentrations in healthy subjects in Delhi. Am J Clin Nutr 72:472–475PubMed
3.
go back to reference Harinarayan CVRT, Prasad UV, Sudhakar D (2008) Vitamin D status in andhra pradesh: a population based study. Indian J Med Res 127:211–218PubMed Harinarayan CVRT, Prasad UV, Sudhakar D (2008) Vitamin D status in andhra pradesh: a population based study. Indian J Med Res 127:211–218PubMed
4.
go back to reference Vupputuri MR, Goswami R, Gupta N, Ray D, Tandon N, Kumar N (2006) Prevalence and functional significance of 25-hydroxyvitamin D deficiency and vitamin D receptor gene polymorphisms in Asian Indians. Am J Clin Nutr 83:1411–1419PubMed Vupputuri MR, Goswami R, Gupta N, Ray D, Tandon N, Kumar N (2006) Prevalence and functional significance of 25-hydroxyvitamin D deficiency and vitamin D receptor gene polymorphisms in Asian Indians. Am J Clin Nutr 83:1411–1419PubMed
5.
go back to reference Zargar AH, Ahmad S, Masoodi SR, Wani AI, Bashir MI, Laway BA, Shah ZA (2007) Vitamin D status in apparently healthy adults in Kashmir Valley of Indian subcontinent. Postgrad Med J 83:713–716PubMedCrossRef Zargar AH, Ahmad S, Masoodi SR, Wani AI, Bashir MI, Laway BA, Shah ZA (2007) Vitamin D status in apparently healthy adults in Kashmir Valley of Indian subcontinent. Postgrad Med J 83:713–716PubMedCrossRef
6.
go back to reference Fabbriciani G, Pirro M, Leli C, Cecchetti A, Callarelli L, Rinonapoli G, Scarponi AM, Mannarino E (2010) Diffuse muscoskeletal pain and proximal myopathy: do not forget hypovitaminosis D. J Clin Rheumatol 16:34–37PubMedCrossRef Fabbriciani G, Pirro M, Leli C, Cecchetti A, Callarelli L, Rinonapoli G, Scarponi AM, Mannarino E (2010) Diffuse muscoskeletal pain and proximal myopathy: do not forget hypovitaminosis D. J Clin Rheumatol 16:34–37PubMedCrossRef
7.
go back to reference Plotnikoff GA, Quigley JM (2003) Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc 78:1463–1470PubMedCrossRef Plotnikoff GA, Quigley JM (2003) Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc 78:1463–1470PubMedCrossRef
8.
go back to reference Lotfi A, Abdel-Nasser AM, Hamdy A, Omran AA, El-Rehany MA (2007) Hypovitaminosis D in female patients with chronic low back pain. Clin Rheumatol 26:1895–1901PubMedCrossRef Lotfi A, Abdel-Nasser AM, Hamdy A, Omran AA, El-Rehany MA (2007) Hypovitaminosis D in female patients with chronic low back pain. Clin Rheumatol 26:1895–1901PubMedCrossRef
9.
go back to reference Schwalfenberg G (2009) Improvement of chronic back pain or failed back surgery with vitamin D repletion: a case series. J Am Board Fam Med 22:69–74PubMedCrossRef Schwalfenberg G (2009) Improvement of chronic back pain or failed back surgery with vitamin D repletion: a case series. J Am Board Fam Med 22:69–74PubMedCrossRef
10.
go back to reference Lee DM, Tajar A, Ulubaev A et al (2009) Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men. J Neurol Neurosurg Psychiatry 80:722–729PubMedCrossRef Lee DM, Tajar A, Ulubaev A et al (2009) Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men. J Neurol Neurosurg Psychiatry 80:722–729PubMedCrossRef
11.
go back to reference Kalyani RR, Stein B, Valiyil R, Manno R, Maynard JW, Crews DC (2010) Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis. J Am Geriatr Soc 58:1299–1310PubMedCrossRef Kalyani RR, Stein B, Valiyil R, Manno R, Maynard JW, Crews DC (2010) Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis. J Am Geriatr Soc 58:1299–1310PubMedCrossRef
12.
go back to reference Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B (2005) Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 293:2257–2264PubMedCrossRef Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B (2005) Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 293:2257–2264PubMedCrossRef
13.
go back to reference Forman JP, Giovannucci E, Holmes MD, Bischoff-Ferrari HA, Tworoger SS, Willett WC, Curhan GC (2007) Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension 49:1063–1069PubMedCrossRef Forman JP, Giovannucci E, Holmes MD, Bischoff-Ferrari HA, Tworoger SS, Willett WC, Curhan GC (2007) Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension 49:1063–1069PubMedCrossRef
14.
go back to reference Sabetta JR, DePetrillo P, Cipriani RJ, Smardin J, Burns LA, Landry ML (2010) Serum 25-hydroxyvitamin D and the incidence of acute viral respiratory tract infections in healthy adults. PLoS One 5:e11088PubMedCrossRef Sabetta JR, DePetrillo P, Cipriani RJ, Smardin J, Burns LA, Landry ML (2010) Serum 25-hydroxyvitamin D and the incidence of acute viral respiratory tract infections in healthy adults. PLoS One 5:e11088PubMedCrossRef
15.
16.
go back to reference Kerr GS, Sabahi I, Richards JS, Caplan L, Cannon GW, Reimold A, Thiele GM, Johnson D, Mikuls TR (2011) Prevalence of vitamin D insufficiency/deficiency in rheumatoid arthritis and associations with disease severity and activity. J Rheumatol 38:53–59PubMedCrossRef Kerr GS, Sabahi I, Richards JS, Caplan L, Cannon GW, Reimold A, Thiele GM, Johnson D, Mikuls TR (2011) Prevalence of vitamin D insufficiency/deficiency in rheumatoid arthritis and associations with disease severity and activity. J Rheumatol 38:53–59PubMedCrossRef
17.
go back to reference Rossini M, Maddali Bongi S, La Montagna G, Minisola G, Malavolta N, Bernini L, Cacace E, Sinigaglia L, Di Munno O, Adami S (2010) Vitamin D deficiency in rheumatoid arthritis: prevalence, determinants and associations with disease activity and disability. Arthritis Res Ther 12:R216PubMedCrossRef Rossini M, Maddali Bongi S, La Montagna G, Minisola G, Malavolta N, Bernini L, Cacace E, Sinigaglia L, Di Munno O, Adami S (2010) Vitamin D deficiency in rheumatoid arthritis: prevalence, determinants and associations with disease activity and disability. Arthritis Res Ther 12:R216PubMedCrossRef
18.
go back to reference Sandhu MS, Casale TB (2010) The role of vitamin D in asthma. Ann Allergy Asthma Immunol 105:191–199, quiz 200-192, 217PubMedCrossRef Sandhu MS, Casale TB (2010) The role of vitamin D in asthma. Ann Allergy Asthma Immunol 105:191–199, quiz 200-192, 217PubMedCrossRef
19.
20.
go back to reference Otani T, Iwasaki M, Sasazuki S, Inoue M, Tsugane S (2007) Plasma vitamin D and risk of colorectal cancer: the Japan Public Health Center-Based Prospective Study. Br J Cancer 97:446–451PubMedCrossRef Otani T, Iwasaki M, Sasazuki S, Inoue M, Tsugane S (2007) Plasma vitamin D and risk of colorectal cancer: the Japan Public Health Center-Based Prospective Study. Br J Cancer 97:446–451PubMedCrossRef
21.
go back to reference Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP (2007) Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr 85:1586–1591PubMed Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP (2007) Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr 85:1586–1591PubMed
22.
go back to reference Amir E, Simmons CE, Freedman OC, Dranitsaris G, Cole DE, Vieth R, Ooi WS, Clemons M (2010) A phase 2 trial exploring the effects of high-dose (10,000 IU/day) vitamin D(3) in breast cancer patients with bone metastases. Cancer 116:284–291PubMedCrossRef Amir E, Simmons CE, Freedman OC, Dranitsaris G, Cole DE, Vieth R, Ooi WS, Clemons M (2010) A phase 2 trial exploring the effects of high-dose (10,000 IU/day) vitamin D(3) in breast cancer patients with bone metastases. Cancer 116:284–291PubMedCrossRef
23.
go back to reference Milaneschi Y, Shardell M, Corsi AM, Vazzana R, Bandinelli S, Guralnik JM, Ferrucci L (2010) Serum 25-hydroxyvitamin D and depressive symptoms in older women and men. J Clin Endocrinol Metab 95:3225–3233PubMedCrossRef Milaneschi Y, Shardell M, Corsi AM, Vazzana R, Bandinelli S, Guralnik JM, Ferrucci L (2010) Serum 25-hydroxyvitamin D and depressive symptoms in older women and men. J Clin Endocrinol Metab 95:3225–3233PubMedCrossRef
24.
go back to reference Lee DM, Tajar A, O’Neill TW et al (2011) Lower vitamin D levels are associated with depression among community-dwelling European men. J Psychopharmacol 25:1320–1328PubMedCrossRef Lee DM, Tajar A, O’Neill TW et al (2011) Lower vitamin D levels are associated with depression among community-dwelling European men. J Psychopharmacol 25:1320–1328PubMedCrossRef
25.
go back to reference Takiishi T, Gysemans C, Bouillon R, Mathieu C (2010) Vitamin D and diabetes. Endocrinol Metab Clin North Am 39:419–446PubMedCrossRef Takiishi T, Gysemans C, Bouillon R, Mathieu C (2010) Vitamin D and diabetes. Endocrinol Metab Clin North Am 39:419–446PubMedCrossRef
26.
go back to reference Zhang C, Qiu C, Hu FB, David RM, van Dam RM, Bralley A, Williams MA (2008) Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. PLoS One 3:e3753PubMedCrossRef Zhang C, Qiu C, Hu FB, David RM, van Dam RM, Bralley A, Williams MA (2008) Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus. PLoS One 3:e3753PubMedCrossRef
27.
go back to reference Michos ED, Melamed ML (2008) Vitamin D and cardiovascular disease risk. Curr Opin Clin Nutr Metab Care 11:7–12PubMedCrossRef Michos ED, Melamed ML (2008) Vitamin D and cardiovascular disease risk. Curr Opin Clin Nutr Metab Care 11:7–12PubMedCrossRef
28.
go back to reference Arya V, Bhambri R, Godbole MM, Mithal A (2004) Vitamin D status and its relationship with bone mineral density in healthy Asian Indians. Osteoporos Int 15:56–61PubMedCrossRef Arya V, Bhambri R, Godbole MM, Mithal A (2004) Vitamin D status and its relationship with bone mineral density in healthy Asian Indians. Osteoporos Int 15:56–61PubMedCrossRef
29.
go back to reference Malhotra N, Mithal A, Gupta S, Shukla M, Godbole M (2009) Effect of vitamin D supplementation on bone health parameters of healthy young Indian women. Arch Osteoporos 4:47–53PubMedCrossRef Malhotra N, Mithal A, Gupta S, Shukla M, Godbole M (2009) Effect of vitamin D supplementation on bone health parameters of healthy young Indian women. Arch Osteoporos 4:47–53PubMedCrossRef
30.
go back to reference Tangpricha V, Pearce EN, Chen TC, Holick MF (2002) Vitamin D insufficiency among free-living healthy young adults. Am J Med 112:659–662PubMedCrossRef Tangpricha V, Pearce EN, Chen TC, Holick MF (2002) Vitamin D insufficiency among free-living healthy young adults. Am J Med 112:659–662PubMedCrossRef
31.
go back to reference Mahdy S, Al-Emadi SA, Khanjar IA, Hammoudeh MM, Sarakbi HA, Siam AM, Abdelrahman MO (2010) Vitamin D status in health care professionals in Qatar. Saudi Med J 31:74–77PubMed Mahdy S, Al-Emadi SA, Khanjar IA, Hammoudeh MM, Sarakbi HA, Siam AM, Abdelrahman MO (2010) Vitamin D status in health care professionals in Qatar. Saudi Med J 31:74–77PubMed
32.
go back to reference Jancin B (2003) Vitamin D deficiency common among physicians in training: long- term risk to bone health. Skin Allergy News 34:55 Jancin B (2003) Vitamin D deficiency common among physicians in training: long- term risk to bone health. Skin Allergy News 34:55
33.
go back to reference Plotnikoff GA, Finch MD, Dusek JA (2012) Impact of vitamin D deficiency on the productivity of a health care workforce. J Occup Environ Med 54:117–121PubMedCrossRef Plotnikoff GA, Finch MD, Dusek JA (2012) Impact of vitamin D deficiency on the productivity of a health care workforce. J Occup Environ Med 54:117–121PubMedCrossRef
Metadata
Title
Widespread vitamin D deficiency among Indian health care professionals
Authors
Maria Beloyartseva
Ambrish Mithal
Parjeet Kaur
Sanjay Kalra
Manash P. Baruah
Satinath Mukhopadhyay
Ganapathy Bantwal
Tushar R. Bandgar
Publication date
01-12-2012
Publisher
Springer-Verlag
Published in
Archives of Osteoporosis / Issue 1-2/2012
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-012-0096-x

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