Top

Osteoporosis International

Published in:

01-02-2010 | Original Article

Age-related changes in biochemical markers of bone turnover and gonadotropin levels and their relationship among Chinese adult women

Authors: X.-Y. Wu, X.-P. Wu, H. Xie, H. Zhang, Y.-Q. Peng, L.-Q. Yuan, X. Su, X.-H. Luo, E.-Y. Liao

Published in: Osteoporosis International | Issue 2/2010

Abstract

Summary

The relationship between the levels of gonadotropic hormones and bone metabolism in Chinese adult women is unclear. Our research shows that a significant positive correlation exists between the levels of gonadotropic hormones and various bone turnover indicators. Follicle-stimulating hormone (FSH) has been found to have a greater influence on all types of bone turnover indicator than luteinizing hormone (LH). Further, FSH has a greater influence on bone formation indicators than on bone resorption indicators.

Introduction

The aim of this study was to investigate the relationship between serum FSH and LH and biochemical markers of bone turnover in native Chinese adult women.

Methods

We conducted a cross-sectional study of 694 healthy Chinese women aged between 20 and 82 years. Serum FSH, LH, bone-specific alkaline phosphatase (BAP), osteocalcin (OC), N-terminal telopeptides of type I collagen, C-terminal telopeptides of type I collagen, urinary NTX, urinary CTX, and urinary deoxypyridinoline (uDPD) were determined.

Results

All types of bone turnover indicator were significantly positively correlated with FSH (r = 0.164–0.626, all P = 0.000) and LH (r = 0.130–0.618, all P = 0.013–0.000). The correlation coefficient between serum FSH and BAP was the highest (r = 0.626), and that between serum FSH and uDPD was the lowest (r = 0.164). The serum gonadotropic hormone levels were higher; concentrations of bone turnover indicators were higher. The extent of the influence of FSH on various bone turnover indicators was approximately seven to 20 times greater than that of LH on these indicators. FSH could explain 43% and 22% of the changes in BAP and OC, respectively; whereas, LH could explain only 2.1% and 1.1%, respectively. FSH could explain approximately 1.9–11.8% of the changes in bone resorption indicators; however, LH had almost no effect on them.

Conclusions

Gonadotropic hormone levels are correlated with the rate of bone turnover in Chinese women: the higher the serum gonadotropic hormone levels in circulation, the higher the levels of bone turnover indicators. FSH has a greater influence on all types of bone turnover indicator than LH; moreover, it has a greater influence on bone formation indicators than on bone resorption indicators.

National Osteoporosis Foundation (2006) Fast facts. http://www.nof.org/osteoporosis/diseasefacts.htm

Nagata-Kobayashi S, Shimbo T, Fukui T (2002) Cost-effectiveness analysis of screening for osteoporosis in postmenopausal Japanese women. J Bone Miner Metab 20:350–357CrossRefPubMed

Liu Z, Piao J, Pang L, Qing X, Nan S, Pan Z, Guo Y, Wang X, Li F, Lui J, Cheng X (2002) The diagnostic criteria for primary osteoporosis and the incidence of osteoporosis in China. J Bone Miner Metab 20:181–189CrossRefPubMed

Riggs BL, Khosla S, Melton LJ 3rd (2002) Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 23:279–302CrossRefPubMed

Prior JC (2006) FSH and bone—important physiology or not? Trends Mol Med 13:1–3CrossRefPubMed

Baron R (2006) FSH versus estrogen: who’s guilty of breaking bones? Cell Metab 3:302–305CrossRefPubMed

Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, Zaidi S, Zhu LL, Yaroslavskiy BB, Zhou H, Zallone A, Sairam MR, Kumar TR, Bo W, Braun J, Cardoso-Landa L, Schaffler MB, Moonga BS, Blair HC, Zaidi M (2006) FSH directly regulates bone mass. Cell 125:247–260CrossRefPubMed

Devleta B, Adem B, Senada S (2004) Hypergonadotropic amenorrhea and bone density: new approach to and old problem. J Bone Miner Metab 22:360–364CrossRefPubMed

Yu Q, Lin S, He F, Li B, Lin Y, Zhang T, Zhang Y (2002) Clinical manifestations of low bone mass in amenorrhea patients with elevated follicular stimulating hormone. Chin Med J 115:1376–1379PubMed

10.

Desai Meena P, Khatkhatay MI, Bhanu Prakash KV, Savardekar LS, Shah RS, Ansari Z (2007) Hormonal profiles and biochemical indices of bone turnover in Indian women. Osteoporos Int 18:923–929CrossRefPubMed

11.

Xu ZR, Wang AH, Wu XP, Zhang H, Sheng ZF, Wu XY, Xie H, Luo XH, Liao EY (2009) Relationship of age-related concentrations of serum FSH and LH with bone mineral density, prevalence of osteoporosis in native Chinese women. Clin Chim Acta 400:8–13CrossRefPubMed

12.

Zhao G, Wang L, Yan R, Dennerstein L (2000) Menopausal symptoms: experience of Chinese women. Climacteric 3:135–144CrossRefPubMed

13.

Hui SL, Perkins AJ, Zhou L, Longcope C, Econs MJ, Peacock M, McClintock C, Johnston CC Jr (2002) Bone loss at the femoral neck in premenopausal white women: effects of weight change and sex-hormone levels. J Clin Endocrinol Metab 87:1539–1543CrossRefPubMed

14.

Sowers MF, Jannausch M, McConnell D, Little R, Greendale GA, Finkelstein JS, Neer RM, Johnston J, Ettinger B (2006) Hormone predictors of bone mineral density changes during the menopausal transition. J Clin Endocrinol Metab 91:1261–1267CrossRefPubMed

15.

Vural F, Vural B, Yucesoy I, Badur S (2005) Ovarian aging and bone metabolism in menstruating women aged 35–50 years. Maturitas 52:147–153CrossRefPubMed

16.

Perrien DS, Achenbach SJ, Bledsoe SE, Walser B, Suva LJ, Khosla S, Gaddy D (2006) Bone turnover across the menopause transition: correlations with inhibins and follicle-stimulating hormone. J Clin Endocrinol Metab 91:1848–1854CrossRefPubMed

17.

Karim N, MacDonald D, Dolan AL, Fogelman I, Wierzbicki AS, Hampson G (2008) The relationship between gonadotrophins, gonadal hormones and bone mass in men. Clin Endocrinol (Oxf) 68:94–101CrossRef

18.

Randolph JF Jr, Sowers M, Bondarenko IV, Harlow SD, Luborsky JL, Little RJ (2004) Change in estradiol and follicle-stimulating hormone across the early menopausal transition: effects of ethnicity and age. J Clin Endocrinol Metab 89:1555–1561CrossRefPubMed

19.

Randolph JF Jr, Sowers M, Gold EB, Mohr BA, Luborsky J, Santoro N, McConnell DS, Finkelstein JS, Korenman SG, Matthews KA, Sternfeld B, Lasley BL (2003) Reproductive hormones in the early menopausal transition: relationship to ethnicity, body size, and menopausal status. J Clin Endocrinol Metab 88:1516–1522CrossRefPubMed

20.

Cohen FJ, Eckert S, Mitlak BH (1998) Geographic differences in bone turnover: data from a multinational study in healthy postmenopausal women. Calcif Tissue Int 63:277–282CrossRefPubMed

21.

Chailurkit LO, Ongphiphadhanakul B, Piaseu N, Saetung S, Rajatanavin R (2001) Biochemical markers of bone turnover and response of bone mineral density to intervention in early postmenopausal women: an experience in a clinical laboratory. Clin Chem 47:1083–1088PubMed

22.

Garnero P, Sornay-Rendu E, Claustrat B, Delmas PD (2000) Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women: the OFELY study. J Bone Miner Res 15:1526–1536CrossRefPubMed

23.

Garnero P, Ferreras M, Karsdal MA, Nicamhlaoibh R, Risteli J, Borel O, Qvist P, Delmas PD, Foged NT, Delaissé JM (2003) The type I collagen fragments ICTP and CTX reveal distinct enzymatic pathways of bone collagen degradation. J Bone Miner Res 18:859–867CrossRefPubMed

24.

Sendak RA, Sampath TK, McPherson JM (2007) Newly reported roles of thyroid-stimulating hormone and follicle-stimulating hormone in bone remodeling. Int Orthop 31:753–757CrossRefPubMed

25.

Mansell JP, Bailey AJ, Yarram SJ (2007) Could bone tissue be a target for luteinizing hormone/chorionic gonadotropin? Mol Cell Endocrinol 169:99–106CrossRef

26.

Ausmanas MK, Tan DA, Jaisamrarn U, Tian XW, Holinka CF (2007) Estradiol, FSH and LH profiles in nine ethnic groups of postmenopausal Asian women: the Pan-Asia menopause (PAM) study. Climacteric 10:427–437CrossRefPubMed

27.

Peichl P, Griesmacher A, Pointinger P, Marteau R, Hartl W, Gruber W, Bröll H (1998) Association between female sex hormones and biochemical markers of bone turnover in peri- and postmenopausal women. Calcif Tissue Int 62:388–394CrossRefPubMed

28.

Sowers MR, Greendale GA, Bondarenko I, Finkelstein JS, Cauley JA, Neer RM, Ettinger B (2003) Endogenous hormones and bone turnover markers in pre- and perimenopausal women: SWAN. Osteoporos Int 14:191–197CrossRefPubMed

29.

Yasui T, Uemura H, Tomita J, Miyatani Y, Yamada M, Miura M, Irahara M (2006) Association of serum undercarboxylated osteocalcin with serum estradiol in pre-, peri- and early post-menopausal women. J Endocrinol Invest 29:913–918PubMed

30.

Iki M, Akiba T, Matsumoto T, Nishino H, Kagamimori S, Kagawa Y, Yoneshima H (2004) Reference database of biochemical markers of bone turnover for the Japanese female population. Japanese population-based osteoporosis (JPOS) study. Osteoporos Int 15:981–991CrossRefPubMed

31.

Liao EY, Wu XP, Deng XG, Huang G, Zhu XP, Long ZF, Wang WB, Tang WL, Zhang H (2000) Age-related bone mineral density, accumulated bone loss rate and prevalence of osteoporosis at multiple skeletal sites in chinese women. Osteoporos Int 13:669–676CrossRef

32.

Wu XP, Liao EY, Zhang H, Shan PF, Cao XZ, Liu SP (2004) Establishment of BMD reference plots and determination of peak BMD at multiple skeletal regions in mainland Chinese women and the diagnosis of osteoporosis. Osteoporos Int 15:71–79CrossRefPubMed

33.

Zaidi M, Sun L, Kumar TR, Sairam MR, Blair H (2006) Both FSH and sex steroids influence bone mass. Cell 127:1080–1081CrossRef

34.

Iqbal J, Sun L, Kumar TR, Blair HC, Zaidi M (2006) Follicle-stimulating hormone stimulates TNF production from immune cells to enhance osteoblast and osteoclast formation. Proc Natl Acad Sci USA 103:14925–14930CrossRefPubMed

35.

Zaidi M, Blair HC, Iqbal J, Zhu LL, Kumar TR, Zallone A, Sun L (2007) Proresorptive actions of FSH and bone loss. Ann N Y Acad Sci 1116:376–382CrossRefPubMed

36.

Seibel MJ, Dunstan CR, Zhou H, Allan CM, Handelsman DJ (2006) Sex steroids, not FSH, influence bone mass. Cell 127:1079CrossRefPubMed

37.

Rajendren G, Zhou H, Moonga BS, Zaidi M, Sun L (2006) Restoration of bone mass in hpg mouse by preoptic area grafting. Ann N Y Acad Sci 1068:341–347CrossRefPubMed

38.

Sims NA, Brennan K, Spaliviero J, Handelsman DJ, Seibel MJ (2006) Perinatal testosterone surge is required for normal adult bone size but not for normal bone remodeling. Am J Physiol Endocrinol Metab 290:E456–E462CrossRefPubMed

39.

Khosla S, Melton LJ 3rd, Atkinson EJ, O’Fallon WM, Klee GG, Riggs BL (1998) Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. J Clin Endocrinol Metab 83:2266–2274CrossRefPubMed

40.

Desai MP, Bhanuprakash KV, Khatkhatay MI, Donde UM (2007) Age-related changes in bone turnover markers and ovarian hormones in premenopausal and postmenopausal Indian women. J Clin Lab Anal 21:55–60CrossRefPubMed

Title: Age-related changes in biochemical markers of bone turnover and gonadotropin levels and their relationship among Chinese adult women
Authors: X.-Y. Wu
X.-P. Wu
H. Xie
H. Zhang
Y.-Q. Peng
L.-Q. Yuan
X. Su
X.-H. Luo
E.-Y. Liao
Publication date: 01-02-2010
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 2/2010
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-009-0943-9

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Age-related changes in biochemical markers of bone turnover and gonadotropin levels and their relationship among Chinese adult women

Abstract

Summary

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 2/2010

Balloon kyphoplasty versus vertebroplasty for treatment of osteoporotic vertebral compression fracture: a prospective, comparative, and randomized clinical study

Osteoporosis and gait and balance disturbances in older sarcopenic obese New Zealanders

Improvement of trochanteric bone quality in an osteoporosis model after short-term treatment with parathyroid hormone: a new mechanical test for trochanteric region of rat femur

Association between circulating osteoprogenitor cell numbers and bone mineral density in postmenopausal osteoporosis

A multicenter survey on profile of care for hip fracture: predictors of mortality and disability

Urinary levels of pentosidine and the risk of fracture in postmenopausal women: the OFELY study