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12-02-2024 | Alkaloids | Original Paper

Vincazalidine A, a unique bisindole alkaloid from Catharanthus roseus

Authors: Yusuke Hirasawa, Ayaka Kase, Akie Okamoto, Keigo Suzuki, Mizuki Hiroki, Toshio Kaneda, Nahoko Uchiyama, Hiroshi Morita

Published in: Journal of Natural Medicines | Issue 2/2024

Abstract

A new dimeric indole alkaloid, vincazalidine A consisting of an aspidosperma type and a modified iboga type with 1-azatricyclo ring system consisting of one azepane and two piperidine rings coupled with an oxazolidine ring was isolated from Catharanthus roseus, and the structure including absolute stereochemistry was elucidated on the basis of spectroscopic data as well as DP4 statistical analysis. Vincazalidine A induced G2 arrest and subsequent apoptosis in human lung carcinoma cell line, A549 cells.

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Title: Vincazalidine A, a unique bisindole alkaloid from Catharanthus roseus
Authors: Yusuke Hirasawa
Ayaka Kase
Akie Okamoto
Keigo Suzuki
Mizuki Hiroki
Toshio Kaneda
Nahoko Uchiyama
Hiroshi Morita
Publication date: 12-02-2024
Publisher: Springer Nature Singapore
Keywords: Alkaloids
Alkaloids
Published in: Journal of Natural Medicines / Issue 2/2024
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-023-01775-x

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Vincazalidine A, a unique bisindole alkaloid from Catharanthus roseus

Abstract

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Keynote webinar | Spotlight on medication adherence

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Abstract

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