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01-06-2019 | Alkaloids | Note

Three new alkaloids from the roots of Sophora tonkinensis

Authors: Chun Wu, Lijun He, Xue Yi, Juan Qin, Yaolan Li, Yubo Zhang, Guocai Wang

Published in: Journal of Natural Medicines | Issue 3/2019

Abstract

A new β-carboline alkaloid (1) and two new matrine-type alkaloids (2 and 3), together with two known alkaloids (4 and 5), were isolated from the roots of Sophora tonkinensis. The new structures were elucidated via extensive analyses of the spectroscopic data (IR, UV, HRESIMS, NMR) and X-ray crystallography. The absolute configuration of 1 was established by electronic circular dichroism data. Herein, is the first report of β-carboline alkaloid in the plant of genus Sophora. In addition, the cytotoxic activities against HepG2 cells of compounds 1–5 were evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Among them, compounds 1, 4 and 5 showed a weak cytotoxic activity with IC₅₀ values of 87.4 ± 7.1, 91.8 ± 3.5 and 48.9 ± 5.2 μM, respectively.

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Title: Three new alkaloids from the roots of Sophora tonkinensis
Authors: Chun Wu
Lijun He
Xue Yi
Juan Qin
Yaolan Li
Yubo Zhang
Guocai Wang
Publication date: 01-06-2019
Publisher: Springer Singapore
Keywords: Alkaloids
Alkaloids
Published in: Journal of Natural Medicines / Issue 3/2019
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-019-01313-8

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Three new alkaloids from the roots of Sophora tonkinensis

Abstract

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Abstract

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