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01-06-2019 | Note

Mutagenetic and anti-allergic studies for evaluation of extracts of Coptis Rhizome produced by an artificial hydroponic system

Authors: Hiroshi Akiyama, Mitsuhiko Nose, Hajime Takiguchi, Keiichi Sugiyama, Riho Tsutsui, Shinsuke Hisaka, Hiroyuki Fuchino, Takayuki Inui, Noriaki Kawano, Takaaki Taguchi, Tadashi Kudo, Nobuo Kawahara, Kayo Yoshimatsu

Published in: Journal of Natural Medicines | Issue 3/2019

Abstract

As a part of the investigation of the safety and efficacy of the cultivated Coptis japonica rhizome extracts using an artificial hydroponic cultivation system, the mutagenetic and anti-allergic activities were evaluated. Some extracts of commercial crude drugs of Coptis sp. were also evaluated for the comparison. None of the extracts showed a significant mutagenicity in Salmonella typhimurium TA102 by the Ames tests, but all the extracts showed in S. typhimurium TA98. The extracts of the hydroponically cultivated rhizomes showed anti-allergic activities against contact hypersensitivity as well as those of commercial crude drugs of Coptis sp. These results suggested the potential of the hydroponically cultivated rhizomes as one of the alternative sources for the medicinal usage.

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Title: Mutagenetic and anti-allergic studies for evaluation of extracts of Coptis Rhizome produced by an artificial hydroponic system
Authors: Hiroshi Akiyama
Mitsuhiko Nose
Hajime Takiguchi
Keiichi Sugiyama
Riho Tsutsui
Shinsuke Hisaka
Hiroyuki Fuchino
Takayuki Inui
Noriaki Kawano
Takaaki Taguchi
Tadashi Kudo
Nobuo Kawahara
Kayo Yoshimatsu
Publication date: 01-06-2019
Publisher: Springer Singapore
Published in: Journal of Natural Medicines / Issue 3/2019
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-019-01288-6

At a glance: The STEP trials

Springer Medicine

Mutagenetic and anti-allergic studies for evaluation of extracts of Coptis Rhizome produced by an artificial hydroponic system

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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