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Journal of Assisted Reproduction and Genetics

Published in:

01-07-2008 | Assisted Reproduction

Viability of frozen-thawed human embryos with one–two blastomeres lysis

Authors: Xiaoying Zheng, Ping Liu, Guian Chen, Jie Qiao, Yuqi Wu, Ming Fan

Published in: Journal of Assisted Reproduction and Genetics | Issue 7/2008

Abstract

Objective

To assess the impact of one–two blastomeres lysis on the viability of thawed day 3 human embryos.

Methods

A retrospective analysis was performed on 248 frozen-thawed embryo replacement cycles in which all embryos were frozen at day 3 at the seven–eight cell stage with ≤10% fragmentation.

Results

Outcomes of transfer cycles with fully intact embryos (intact group) were compared with those in which all transferred embryos have lost one–two blastomeres (damage group). Comparable pregnancy rates (38.46% vs 38.64%), birth rates (34.62% vs 36.36%) and implantation rates (26.31% vs 26.25%) were obtained in intact and damage groups. These results were also not significantly different from mixed transfer cycles in which one intact embryo and one damaged embryo were transferred together.

Conclusion

The developmental potential of partially damaged cryopreserved human embryos with less than 25% cells loss is comparable to that of fully intact embryos. Presence of one–two lysed blastomeres in the thawed day 3 embryo does not appear to have a negative influence on the further development of the sibling intact cells.

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Title: Viability of frozen-thawed human embryos with one–two blastomeres lysis
Authors: Xiaoying Zheng
Ping Liu
Guian Chen
Jie Qiao
Yuqi Wu
Ming Fan
Publication date: 01-07-2008
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 7/2008
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-008-9224-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Viability of frozen-thawed human embryos with one–two blastomeres lysis

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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