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Journal of Assisted Reproduction and Genetics

Published in:

01-07-2008 | Assisted Reproduction

Short gamete co-incubation during in vitro fertilization decreases the fertilization rate and does not improve embryo quality: a prospective auto controlled study

Authors: V. Barraud-Lange, C. Sifer, K. Pocaté, A. Ziyyat, B. Martin-Pont, R. Porcher, J. N. Hugues, J. P. Wolf

Published in: Journal of Assisted Reproduction and Genetics | Issue 7/2008

Abstract

Purpose

Evaluate the effect of short gamete incubation on fertilization rate and embryo quality.

Methods

A prospective study has been performed. Two thousand five hundred and forty seven sibling oocytes from 240 couples undergoing IVF attempts were allocated to a short (1 h) or a standard (18 h) insemination procedure. Diploid fertilization rate (two pronuclei, 2PN), polyspermy (>2PN) and embryo quality were compared.

Results

The fertilization rate was statistically lower in the short insemination group compared to the standard insemination one (64.9% and 70.1%; P = 0.039), with a similar polyspermy rate observed between the two groups. A slight, but non significant, increase was observed concerning good embryo quality rate in the short insemination group when compared to the standard insemination, both at day 2 (60.1 vs. 58.1%; P = 0.06) and day 3 (53.2 vs. 48.5%; P = 0.22).

Conclusion

This new study highlights that a 1 h gamete exposure decreases the fertilization rate and does not improve embryo quality compared with a standard 18 h insemination procedure.

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Title: Short gamete co-incubation during in vitro fertilization decreases the fertilization rate and does not improve embryo quality: a prospective auto controlled study
Authors: V. Barraud-Lange
C. Sifer
K. Pocaté
A. Ziyyat
B. Martin-Pont
R. Porcher
J. N. Hugues
J. P. Wolf
Publication date: 01-07-2008
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 7/2008
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-008-9240-3

At a glance: The STEP trials

Springer Medicine

Short gamete co-incubation during in vitro fertilization decreases the fertilization rate and does not improve embryo quality: a prospective auto controlled study

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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